Caffeine improves endurance in 75-yr-old citizens: A randomized, double-blind, placebo-controlled, crossover study

Journal of Applied Physiology

Volumn 99, Issue 6, 2005, Pages 2302-2306

  Norager, C B ^a   Jensen, M B ^a   Madsen, M R ^a   Laurberg, S ^b  

^a HERNING HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Elderly; Fatigue; Perceived exertion; Postural stability

Indexed keywords

CAFFEINE; PLACEBO;

AGED; AGING; ARTICLE; BODY POSTURE; CLINICAL ARTICLE; CLINICAL TRIAL; COFFEE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; DRUG MECHANISM; DRUG WITHDRAWAL; ENDURANCE; EXERCISE; FATIGUE; FEMALE; HEADACHE; HEART RATE; HUMAN; MALE; MUSCLE STRENGTH; NAUSEA; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RANDOMIZED CONTROLLED TRIAL; RESPONSE TIME; RESTLESSNESS; TREATMENT OUTCOME; WALKING SPEED;

ADMINISTRATION, ORAL; AGED; CAFFEINE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERTION; FEMALE; HUMANS; ISOMETRIC CONTRACTION; LOCOMOTION; MALE; MUSCLE, SKELETAL; PHYSICAL ENDURANCE; PLACEBO EFFECT; POSTURE; PSYCHOMOTOR PERFORMANCE;

EID: 28044459825     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00309.2005     Document Type: Article

References (43)

1. Armitage P and Berry G. Statistical Methods in Medical Research (2nd ed.). Oxford, UK: Blackwell Scientific, 1987, p. 222-226.
2. Borg G. Psychophysical scaling with applications in physical work and the perception of exertion. Scand J Work Environ Health 16, Suppl 1: 55-58, 1990.
3. Brenner I, Shek PN, Zamecnik J, and Shephard RJ. Stress hormones and the immunological responses to heat and exercise. Int J Sports Med 19: 130-143, 1998.
4. Clausen T and Flatman JA. The effect of catecholamines on Na-K transport and membrane potential in rat soleus muscle. J Physiol 270: 383-414, 1977.
5. Costill DL, Dalsky GP, and Fink WJ. Effects of caffeine ingestion on metabolism and exercise performance. Med Sci Sports Exerc 10: 155-158, 1978.
6. Denadai BS and Denadai ML. Effects of caffeine on time to exhaustion in exercise performed below and above the anaerobic threshold. Braz J Med Biol Res 31: 581-585, 1998.
7. Era P, Rantanen T, Avlund K, Gause-Nilsson I, Heikkinen E, Schroll M, et al. Maximal isometric muscle strength and anthropometry in 75-year-old men and women in three Nordic localities. Scand J Med Sci Sports 4: 26-31, 1994.
8. Era P, Berg S, and Schroll M. Psychomotor speed and physical activity in 75-year-old residents in three Nordic localities. Aging (Milano) 7: 195-204, 1995.
9. Falk B, Burstein R, Ashkenazi I, Spilberg O, Alter J, Zylber-Katz E, Rubinstein A, Bashan N, and Shapiro Y. The effect of caffeine ingestion on physical performance after prolonged exercise. Eur J Appl Physiol 59: 168-173, 1989.
10. Franks HM, Hagedorn H, Hensley VR, Hensley WJ, and Starmer GA. The effect of caffeine on human performance, alone and in combination with ethanol. Psychopharmacologia 45: 177-181, 1975.
11. Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med 31: 785-807, 2001.
12. Graham TE, Hibbert E, and Sathasivam P. Metabolic and exercise endurance effects of coffee and caffeine ingestion. J Appl Physiol 85: 883-889, 1998.
13. Graham TE, Rush JW, and Van Soeren MH. Caffeine and exercise: metabolism and performance. Can J Appl Physiol 19: 111-138, 1994.
14. Graham TE, Sathasivam P, Rowland M, Marko N, Greer F, and Battram D. Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test. Can J Physiol Pharmacol 79: 559-565, 2001.
15. Graham TE and Spriet LL. Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. J Appl Physiol 78: 867-874, 1995.
16. Greden JF. Anxiety or caffeinism: a diagnostic dilemma. Am J Psychiatry 131: 1089-1092, 1974.
17. Greer F, Friars D, and Graham TE. Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance. J Appl Physiol 89: 1837-1844, 2000.
18. Hand DJ and Everitt BS (Editors). The Statistical Consultant in Action. Cambridge, UK: Cambridge University Press, 1987.
19. Jacobson BH and Edwards SW. Influence of two levels of caffeine on maximal torque at selected angular velocities. J Sports Med Phys Fitness 31: 147-153, 1991.
20. James JE. Acute and chronic effects of caffeine on performance, mood, headache, and sleep. Neuropsychobiology 38: 32-41, 1998.
21. Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Cotreau MM, Harmatz JS, and Shader RI. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol 37: 693-703, 1997.
22. Lane JD. Effects of brief caffeinated-beverage deprivation on mood, symptoms, and psychomotor performance. Pharmacol Biochem Behav 58: 203-208, 1997.
23. Lee S, Hudson R, Kilpatrick K, Graham TE, and Ross R. Caffeine ingestion is associated with reductions in glucose uptake independent of obesity and type 2 diabetes before and after exercise training. Diabetes Care 28: 566-572, 2005.
24. Liguori A and Robinson JH. Caffeine antagonism of alcohol-induced driving impairment. Drug Alcohol Depend 63: 123-129, 2001.
25. Lin AS, Uhde TW, Slate SO, and McCann UD. Effects of intravenous caffeine administered to healthy males during sleep. Depress Anxiety 5: 21-28, 1997.
26. +] in humans. J Appl Physiol 74: 1149-1155, 1993.
27. Lovallo WR, al'Absi M, Blick K, Whitsett TL, and Wilson MF. Stress-like adrenocorticotropin responses to caffeine in young healthy men. Pharmacol Biochem Behav 55: 365-369, 1996.
28. Meeusen R and De Meirleir K. Exercise and brain neurotransmission. Sports Med 20: 160-188, 1995.
29. Olah ME and Stiles GL. Adenosine receptor subtypes: characterization and therapeutic regulation. Annu Rev Pharmacol Toxicol 35: 581-606, 1995.
30. Overend TJ, Cunningham DA, Paterson DH, and Smith WD. Physiological responses of young and elderly men to prolonged exercise at critical power. Eur J Appl Physiol 64: 187-193, 1992.
31. Pajala S, Era P, Koskenvuo M, Kaprio J, Tolvanen A, Heikkinen E, Tiainenk K, and Rantanen T. Contribution of genetic and environmental effects to postural balance in older female twins. J Appl Physiol 96: 308-315, 2004.
32. Parry-Billings M, Blomstrand E, McAndrew N, and Newsholme EA. A communicational link between skeletal muscle, brain, and cells of the immune system. Int J Sports Med 11, Suppl 2: S122-S128, 1990.
33. Pasman WJ, Van Baak MA, Jeukendrup AE, and de Haan A. The effect of different dosages of caffeine on endurance performance time. Int J Sports Med 16: 225-230, 1995.
34. Plaskett CJ and Cafarelli E. Caffeine increases endurance and attenuates force sensation during submaximal isometric contractions. J Appl Physiol 91: 1535-1544, 2001.
35. Rees K, Allen D, and Lader M. The influences of age and caffeine on psychomotor and cognitive function. Psychopharmacology (Berl) 145: 181-188, 1999.
36. Robertson D, Frolich JC, Carr RK, Watson JT, Hollifleld JW, Shand DG, and Oates JA. Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med 298: 181-186, 1978.
37. Rodigues LOC, Russo AK, Silva AC, Picarro IC, Silva FRPT, Zocaib PMS, and Soares DD. Effects of caffeine on the rate of perceived exertion. Braz J Med Biol Res 23: 965-968, 1990.
38. Ryu S, Choi SK, Joung SS, Suh H, Cha YS, Lee S, and Lim K. Caffeine as a lipolytic food component increases endurance performance in rats and athletes. J Nutr Sci Vitaminol (Tokyo) 47: 139-146, 2001.
39. Sattin A and Rall TW. The effect of adenosine and adenine nucleotides on the cyclic adenosine 3′,5′-phosphate content of guinea pig cerebral cortex slices. Mol Pharmacol 6: 13-23, 1970.
40. Schuh KJ and Griffiths RR. Caffeine reinforcement: the role of withdrawal. Psychopharmacology (Berl) 130: 320-326, 1997.
41. Swift CG and Tiplady B. The effects of age on the response to caffeine. Psychopharmacology (Berl) 94: 29-31, 1988.
42. Thong FS and Graham TE. Caffeine-induced impairment of glucose tolerance is abolished by β-adrenergic receptor blockade in humans. J Appl Physiol 92: 2347-2352, 2002.
43. Williams JH, Signorile JF, Barnes WS, and Henrich TW. Caffeine, maximal power output and fatigue. Br J Sports Med 22: 132-134, 1988.