메뉴 건너뛰기




Volumn 24, Issue 19, 2006, Pages 3081-3088

Molecular load of pathologically occult metastases in pelvic lymph nodes is an independent prognostic marker of biochemical failure after localized prostate cancer treatment

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANDROGEN; CYPROTERONE ACETATE; GONADORELIN AGONIST; PALLADIUM 103; PROSTATE SPECIFIC ANTIGEN; MESSENGER RNA; TUMOR MARKER;

EID: 33746017350     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.03.6020     Document Type: Article
Times cited : (48)

References (51)
  • 2
    • 0027211001 scopus 로고
    • The use of prostate specific antigen, clinical stage, and Gleason score to predict pathologic stage in men with localized prostate cancer
    • Partin AW, Yoo J, Carter HB, et al: The use of prostate specific antigen, clinical stage, and Gleason score to predict pathologic stage in men with localized prostate cancer. J Urol 150:110-114, 1993
    • (1993) J Urol , vol.150 , pp. 110-114
    • Partin, A.W.1    Yoo, J.2    Carter, H.B.3
  • 3
    • 0032550753 scopus 로고    scopus 로고
    • A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer
    • Kattan M, Eastham J, Stapleton A, et al: A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer. J Natl Cancer Inst 90:766-771, 1998
    • (1998) J Natl Cancer Inst , vol.90 , pp. 766-771
    • Kattan, M.1    Eastham, J.2    Stapleton, A.3
  • 4
    • 0032538069 scopus 로고    scopus 로고
    • Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer
    • D'Amico AV, Whittington R, Malkowicz SB, et al: Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 280:969-974, 1998
    • (1998) JAMA , vol.280 , pp. 969-974
    • D'Amico, A.V.1    Whittington, R.2    Malkowicz, S.B.3
  • 5
    • 1542438630 scopus 로고    scopus 로고
    • Pretreatment nomograms that predicts 5-year probability of metastasis following three-dimensional conformal radiation therapy for localized prostate cancer
    • Kattan MW, Zelefsky MJ, Kupelian PA, et al: Pretreatment nomograms that predicts 5-year probability of metastasis following three-dimensional conformal radiation therapy for localized prostate cancer. J Clin Oncol 21:4568-4571, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 4568-4571
    • Kattan, M.W.1    Zelefsky, M.J.2    Kupelian, P.A.3
  • 6
    • 0242692716 scopus 로고    scopus 로고
    • Determinants of prostate cancer specific survival following radiation therapy during the prostate specific antigen era
    • D'Amico AV, Cote K, Lofredo M, et al: Determinants of prostate cancer specific survival following radiation therapy during the prostate specific antigen era. J Urol 170:S42-S47, 2003
    • (2003) J Urol , vol.170
    • D'Amico, A.V.1    Cote, K.2    Lofredo, M.3
  • 7
    • 2942677245 scopus 로고    scopus 로고
    • The changing face of low-risk prostate cancer: Trends in clinical presentation and primary management
    • Cooperberg MR, Lubeck DP, Meng MV, et al: The changing face of low-risk prostate cancer: Trends in clinical presentation and primary management. J Clin Oncol 22:2141-2149, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 2141-2149
    • Cooperberg, M.R.1    Lubeck, D.P.2    Meng, M.V.3
  • 8
    • 0031014008 scopus 로고    scopus 로고
    • Increasing prostate-specific antigen profile following definitive radiation therapy for localized prostate cancer: Clinical observations
    • Lee W, Hanks G, Hanlon A: Increasing prostate-specific antigen profile following definitive radiation therapy for localized prostate cancer: Clinical observations. J Clin Oncol 15:230-237, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 230-237
    • Lee, W.1    Hanks, G.2    Hanlon, A.3
  • 9
    • 0141729468 scopus 로고    scopus 로고
    • Surrogate end point for prostate cancer-specific mortality after radical prostatectomy or radiation therapy
    • D'Amico AV, Moul JW, Carroll PR, et al: Surrogate end point for prostate cancer-specific mortality after radical prostatectomy or radiation therapy. J Natl Cancer Inst 95:1376-1383, 2003
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1376-1383
    • D'Amico, A.V.1    Moul, J.W.2    Carroll, P.R.3
  • 10
    • 0032771768 scopus 로고    scopus 로고
    • The significance of recurrent PSA after radical prostatectomy: Benign versus malignant sources
    • Ravery V: The significance of recurrent PSA after radical prostatectomy: Benign versus malignant sources. Sem Urol Oncol 17:127-129, 1999
    • (1999) Sem Urol Oncol , vol.17 , pp. 127-129
    • Ravery, V.1
  • 12
    • 0033540004 scopus 로고    scopus 로고
    • Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer
    • Messing EM, Manola J, Sarosdy M, et al: Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer. N Engl J Med 341:1781-1788, 1999
    • (1999) N Engl J Med , vol.341 , pp. 1781-1788
    • Messing, E.M.1    Manola, J.2    Sarosdy, M.3
  • 13
    • 4143053657 scopus 로고    scopus 로고
    • Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: Long-term results
    • Roehl KA, Han M, Ramos CG, et al: Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: Long-term results. J Urol 172:910-914, 2004
    • (2004) J Urol , vol.172 , pp. 910-914
    • Roehl, K.A.1    Han, M.2    Ramos, C.G.3
  • 14
    • 0027442815 scopus 로고
    • Detection of micrometastatic prostate cancer cells in lymph nodes by reverse transcriptase-polymerase chain reaction
    • Deguchi T, Doi T, Ehara H, et al: Detection of micrometastatic prostate cancer cells in lymph nodes by reverse transcriptase-polymerase chain reaction. Cancer Res 53:5350-5354, 1993
    • (1993) Cancer Res , vol.53 , pp. 5350-5354
    • Deguchi, T.1    Doi, T.2    Ehara, H.3
  • 15
    • 0028882504 scopus 로고
    • A rapid and simple method for the detection of prostate-specific antigen mRNA in archival tissue specimens using a reverse transcription-polymerase chain reaction assay
    • Edelstein RA, Krane RJ, Babayan RK, et al: A rapid and simple method for the detection of prostate-specific antigen mRNA in archival tissue specimens using a reverse transcription-polymerase chain reaction assay. Urology 45:597-603, 1995
    • (1995) Urology , vol.45 , pp. 597-603
    • Edelstein, R.A.1    Krane, R.J.2    Babayan, R.K.3
  • 16
    • 0030800663 scopus 로고    scopus 로고
    • Prospective analysis of prostate-specific markers in pelvic lymph nodes of patients with high-risk prostate cancer
    • Ferrari A, Stone N, Eyler J, et al: Prospective analysis of prostate-specific markers in pelvic lymph nodes of patients with high-risk prostate cancer. J Natl Cancer Inst 89:1498-1504, 1997
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1498-1504
    • Ferrari, A.1    Stone, N.2    Eyler, J.3
  • 17
    • 4444269507 scopus 로고    scopus 로고
    • Prognostic value of combined "triple"-reverse transcription-PCR analysis for prostate-specific antigen, human kallikrein 2, and prostate-specific membrane antigen mRNA in peripheral blood and lymph nodes of prostate cancer patients
    • Kurek R, Nunez G, Tselis N, et al: Prognostic value of combined "triple"-reverse transcription-PCR analysis for prostate-specific antigen, human kallikrein 2, and prostate-specific membrane antigen mRNA in peripheral blood and lymph nodes of prostate cancer patients. Clin Cancer Res 10:5808-5814, 2004
    • (2004) Clin Cancer Res , vol.10 , pp. 5808-5814
    • Kurek, R.1    Nunez, G.2    Tselis, N.3
  • 18
    • 0038175364 scopus 로고    scopus 로고
    • Detection of clinically significant, occult prostate cancer metastases in lymph nodes using a splice variant-specific RT-PCR assay for human glandular kallikrein
    • Shariat SF, Kattan MW, Erdamar S, et al: Detection of clinically significant, occult prostate cancer metastases in lymph nodes using a splice variant-specific RT-PCR assay for human glandular kallikrein. J Clin Oncol 21:1223-1231, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 1223-1231
    • Shariat, S.F.1    Kattan, M.W.2    Erdamar, S.3
  • 19
    • 0028906648 scopus 로고
    • Enhanced reverse transcriptase-polymerase chain reaction for prostate specific antigen as an indicator of true pathologic stage in patients with prostate cancer
    • Katz AE, deVries GM, Begg MD, et al: Enhanced reverse transcriptase-polymerase chain reaction for prostate specific antigen as an indicator of true pathologic stage in patients with prostate cancer. Cancer 75:1642-1648, 1995
    • (1995) Cancer , vol.75 , pp. 1642-1648
    • Katz, A.E.1    deVries, G.M.2    Begg, M.D.3
  • 20
    • 0028854977 scopus 로고
    • Sensitive detection of prostatic hematogenous tumor cell dissemination using prostate specific antigen and prostate specific membrane-derived primers in the polymerase chain reaction
    • Israeli R, Miller WH, Su SL, et al: Sensitive detection of prostatic hematogenous tumor cell dissemination using prostate specific antigen and prostate specific membrane-derived primers in the polymerase chain reaction. J Urol 153:573-577, 1994
    • (1994) J Urol , vol.153 , pp. 573-577
    • Israeli, R.1    Miller, W.H.2    Su, S.L.3
  • 21
    • 0036682416 scopus 로고    scopus 로고
    • Preoperative combined nested reverse transcriptase polymerase chain reaction for prostate-specific antigen and prostate-specific membrane antigen does not correlate with pathologic stage or biochemical failure in patients with localized prostate cancer undergoing radical prostatectomy
    • Thomas J, Gupta M, Grasso Y, et al: Preoperative combined nested reverse transcriptase polymerase chain reaction for prostate-specific antigen and prostate-specific membrane antigen does not correlate with pathologic stage or biochemical failure in patients with localized prostate cancer undergoing radical prostatectomy. J Clin Oncol 20:3213-3218, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 3213-3218
    • Thomas, J.1    Gupta, M.2    Grasso, Y.3
  • 22
    • 0037321384 scopus 로고    scopus 로고
    • Detection and isolation of prostate cancer cells from peripheral blood and bone marrow
    • Ellis WJ, Pfitzenmaier J, Colli J, et al: Detection and isolation of prostate cancer cells from peripheral blood and bone marrow. Urology 61:277-281, 2003
    • (2003) Urology , vol.61 , pp. 277-281
    • Ellis, W.J.1    Pfitzenmaier, J.2    Colli, J.3
  • 24
    • 0030802626 scopus 로고    scopus 로고
    • Laparoscopic pelvic lymph node dissection: Comparison of extended and modified techniques
    • Stone N, Stock R, Unger P: Laparoscopic pelvic lymph node dissection: Comparison of extended and modified techniques. J Urol 158:1891-1894, 1997
    • (1997) J Urol , vol.158 , pp. 1891-1894
    • Stone, N.1    Stock, R.2    Unger, P.3
  • 25
    • 0018347466 scopus 로고
    • Extended pelvic lymphadenectomy for prostatic cancer
    • Golimbu M, Morales P, Al-Askari S, et al: Extended pelvic lymphadenectomy for prostatic cancer. J Urol 121:617-621, 1979
    • (1979) J Urol , vol.121 , pp. 617-621
    • Golimbu, M.1    Morales, P.2    Al-Askari, S.3
  • 26
    • 0029311918 scopus 로고
    • Brachytherapy for prostate cancer: Real-time three-dimensional interactive seed implantation
    • Stone NN, Stock RG: Brachytherapy for prostate cancer: Real-time three-dimensional interactive seed implantation. Techniq Urol 1:72-80, 1995
    • (1995) Techniq Urol , vol.1 , pp. 72-80
    • Stone, N.N.1    Stock, R.G.2
  • 28
    • 0024593380 scopus 로고
    • The value of serum prostate specific antigen determinations before and after radical prostatectomy
    • Lange P, Ercole C, Lightner D, et al: The value of serum prostate specific antigen determinations before and after radical prostatectomy. J Urol 141:873-879, 1989
    • (1989) J Urol , vol.141 , pp. 873-879
    • Lange, P.1    Ercole, C.2    Lightner, D.3
  • 29
    • 0030963436 scopus 로고    scopus 로고
    • Prostate-specific antigen after anatomic radical retropubic prostatectomy: Patterns of recurrence and cancer control
    • Pound C, Partin A, Epstein J, et al: Prostate-specific antigen after anatomic radical retropubic prostatectomy: Patterns of recurrence and cancer control. Urol Clin North Am 24:395-406, 1997
    • (1997) Urol Clin North Am , vol.24 , pp. 395-406
    • Pound, C.1    Partin, A.2    Epstein, J.3
  • 30
    • 0030906817 scopus 로고    scopus 로고
    • Consensus statement: Guidelines for PSA following radiation therapy
    • American Society for Therapeutic Radiology and Oncology Consensus Panel
    • American Society for Therapeutic Radiology and Oncology Consensus Panel: Consensus statement: Guidelines for PSA following radiation therapy. Int J Radiat Oncol Biol Phys 37:1035-1041, 1997
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , pp. 1035-1041
  • 31
    • 0033526343 scopus 로고    scopus 로고
    • Radiation therapy for clinically localized prostate cancer: A multi-institutional pooled analysis
    • Shipley W, Thames H, Sandler H, et al: Radiation therapy for clinically localized prostate cancer: A multi-institutional pooled analysis. JAMA 281:1598-1603, 1999
    • (1999) JAMA , vol.281 , pp. 1598-1603
    • Shipley, W.1    Thames, H.2    Sandler, H.3
  • 32
    • 0034817278 scopus 로고    scopus 로고
    • Long term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy: The 15-year Johns Hopkins experience
    • Han M, Partin A, Pound C, et al: Long term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy: The 15-year Johns Hopkins experience. Urol Clin North Am 28:555-565, 2001
    • (2001) Urol Clin North Am , vol.28 , pp. 555-565
    • Han, M.1    Partin, A.2    Pound, C.3
  • 33
    • 0036141891 scopus 로고    scopus 로고
    • Cancer control with radical prostatectomy alone in 1000 consecutive patients
    • Hull GW, Rabbani F, Abbas F, et al: Cancer control with radical prostatectomy alone in 1000 consecutive patients. J Urol 167:528-534, 2002
    • (2002) J Urol , vol.167 , pp. 528-534
    • Hull, G.W.1    Rabbani, F.2    Abbas, F.3
  • 34
    • 0036135345 scopus 로고    scopus 로고
    • Radical prostatectomy for pathological Gleason 8 or greater prostate cancer: Influence of concomitant pathological variables
    • Lau W, Bergstralh E, Blute M, et al: Radical prostatectomy for pathological Gleason 8 or greater prostate cancer: Influence of concomitant pathological variables. J Urol 167:117, 2002
    • (2002) J Urol , vol.167 , pp. 117
    • Lau, W.1    Bergstralh, E.2    Blute, M.3
  • 35
    • 0037213182 scopus 로고    scopus 로고
    • Predicting recurrence after radical prostatectomy for patients with high risk prostate cancer
    • Grossfeld G, Latini D, Lubeck D, et al: Predicting recurrence after radical prostatectomy for patients with high risk prostate cancer. J Urol 169:157-163, 2003
    • (2003) J Urol , vol.169 , pp. 157-163
    • Grossfeld, G.1    Latini, D.2    Lubeck, D.3
  • 36
    • 1042301961 scopus 로고    scopus 로고
    • Evaluating a new marker's predictive contribution
    • Kattan MW: Evaluating a new marker's predictive contribution. Clin Cancer Res 10:822-824, 2004
    • (2004) Clin Cancer Res , vol.10 , pp. 822-824
    • Kattan, M.W.1
  • 37
    • 0027416813 scopus 로고
    • Screening for occult nodal metastasis in localized carcinoma of the prostate
    • Gomella LG, White JL, McCue PA, et al: Screening for occult nodal metastasis in localized carcinoma of the prostate. J Urol 149:776-778, 1993
    • (1993) J Urol , vol.149 , pp. 776-778
    • Gomella, L.G.1    White, J.L.2    McCue, P.A.3
  • 38
    • 0034671994 scopus 로고    scopus 로고
    • Molecular and immunohistochemical staging of men with seminal vesicle invasion and negative pelvic lymph nodes at radical prostatectomy
    • Potter SR, Mangold LA, Shue MJ, et al: Molecular and immunohistochemical staging of men with seminal vesicle invasion and negative pelvic lymph nodes at radical prostatectomy. Cancer 89:2577-2586, 2000
    • (2000) Cancer , vol.89 , pp. 2577-2586
    • Potter, S.R.1    Mangold, L.A.2    Shue, M.J.3
  • 39
    • 0033526309 scopus 로고    scopus 로고
    • Natural history of progression after PSA elevation following radical prostatectomy
    • Pound CR, Partin AW, Eisenberger MA, et al: Natural history of progression after PSA elevation following radical prostatectomy. JAMA 281:1591-1597, 1999
    • (1999) JAMA , vol.281 , pp. 1591-1597
    • Pound, C.R.1    Partin, A.W.2    Eisenberger, M.A.3
  • 40
    • 85047699965 scopus 로고    scopus 로고
    • Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: A search database study
    • Freedland SJ, Isaacs WB, Platz EA, et al: Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: A search database study. J Clin Oncol 23:7546-7554, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 7546-7554
    • Freedland, S.J.1    Isaacs, W.B.2    Platz, E.A.3
  • 41
    • 0030815150 scopus 로고    scopus 로고
    • Recurrence patterns after radical prostatectomy: Clinical usefulness of prostate specific antigen doubling times and log slope prostate specific antigen
    • Patel A, Dorey F, Franklin J, et al: Recurrence patterns after radical prostatectomy: Clinical usefulness of prostate specific antigen doubling times and log slope prostate specific antigen. J Urol 158:1441-1445, 1997
    • (1997) J Urol , vol.158 , pp. 1441-1445
    • Patel, A.1    Dorey, F.2    Franklin, J.3
  • 42
    • 0030827106 scopus 로고    scopus 로고
    • Kinetics of serum prostate-specific antigen after external beam radiation for clinically localized prostate cancer
    • Zagars G, Pollack A: Kinetics of serum prostate-specific antigen after external beam radiation for clinically localized prostate cancer. Radiother Oncol 44:213-221, 1997
    • (1997) Radiother Oncol , vol.44 , pp. 213-221
    • Zagars, G.1    Pollack, A.2
  • 43
    • 0141919737 scopus 로고    scopus 로고
    • The long-term clinical impact of biochemical recurrence of prostate cancer 5 or more years after radical prostatectomy
    • Ward J, Blute M, Slezak J, et al: The long-term clinical impact of biochemical recurrence of prostate cancer 5 or more years after radical prostatectomy. J Urol 170:2260-2264, 2003
    • (2003) J Urol , vol.170 , pp. 2260-2264
    • Ward, J.1    Blute, M.2    Slezak, J.3
  • 44
    • 2442562364 scopus 로고    scopus 로고
    • Predictors of metastatic disease in men with biochemical failure after radical prostatectomy
    • Okotie O, Aaronson W, Wiedler J, et al: Predictors of metastatic disease in men with biochemical failure after radical prostatectomy. J Urol 171:2260-2264, 2004
    • (2004) J Urol , vol.171 , pp. 2260-2264
    • Okotie, O.1    Aaronson, W.2    Wiedler, J.3
  • 45
    • 2542590276 scopus 로고    scopus 로고
    • Prostate-specific antigen doubling time as a surrogate marker for evaluation of oncologic drugs to treat prostate cancer
    • Kelloff GJ, Coffey DS, Chabner BA, et al: Prostate-specific antigen doubling time as a surrogate marker for evaluation of oncologic drugs to treat prostate cancer. Clin Cancer Res 10:3927-3933, 2004
    • (2004) Clin Cancer Res , vol.10 , pp. 3927-3933
    • Kelloff, G.J.1    Coffey, D.S.2    Chabner, B.A.3
  • 46
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation
    • Luzzi K, MacDonald I, Schmidt E, et al: Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation. Am J Path 153:865-873, 1998
    • (1998) Am J Path , vol.153 , pp. 865-873
    • Luzzi, K.1    MacDonald, I.2    Schmidt, E.3
  • 47
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • Ghiso J, Kovalski K, Ossowski L: Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 147:89-103, 1999
    • (1999) J Cell Biol , vol.147 , pp. 89-103
    • Ghiso, J.1    Kovalski, K.2    Ossowski, L.3
  • 48
    • 0029977061 scopus 로고    scopus 로고
    • Analysis of risk factors for progression in patients with pathologically confined prostate cancers after radical retropubic prostatectomy
    • Lerner S, Blute M, Bergstralh E, et al: Analysis of risk factors for progression in patients with pathologically confined prostate cancers after radical retropubic prostatectomy. J Urol 156:137-143, 1996
    • (1996) J Urol , vol.156 , pp. 137-143
    • Lerner, S.1    Blute, M.2    Bergstralh, E.3
  • 49
    • 17244382914 scopus 로고    scopus 로고
    • Treatment of patients with high risk localized prostate cancer: Results from cancer of the prostate strategic urological research endeavor (CaPSURE)
    • Meng MV, Elkin EP, Latini DM, et al: Treatment of patients with high risk localized prostate cancer: Results from cancer of the prostate strategic urological research endeavor (CaPSURE). J Urol 173:1557-1561, 2005
    • (2005) J Urol , vol.173 , pp. 1557-1561
    • Meng, M.V.1    Elkin, E.P.2    Latini, D.M.3
  • 50
    • 34247350320 scopus 로고    scopus 로고
    • Long-term hazard of progression after radicial prostatectomy for clinically localized prostate cancer: Continued risk of biochemical failure after 5 years
    • Amling C, Blute M, Bergstralh E, et al: Long-term hazard of progression after radicial prostatectomy for clinically localized prostate cancer: Continued risk of biochemical failure after 5 years J Urol 167:528-534, 2000
    • (2000) J Urol , vol.167 , pp. 528-534
    • Amling, C.1    Blute, M.2    Bergstralh, E.3
  • 51
    • 22844434877 scopus 로고    scopus 로고
    • Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy
    • Freedland SJ, Humphreys EB, Mangold LA, et al: Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy. JAMA 294:433-439, 2005
    • (2005) JAMA , vol.294 , pp. 433-439
    • Freedland, S.J.1    Humphreys, E.B.2    Mangold, L.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.