Development and validation of an HPLC method for the determination of spironolactone and its metabolites in paediatric plasma samples

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 839, Issue 1-2, 2006, Pages 36-44

  Sandall, J M ^a   Millership, J S ^a   Collier, P S ^a   McElnay, J C ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

7 Thiomethylspirolactone; Canrenone; Children; HPLC; Pharmacokinetics; Spironolactone

Indexed keywords

CONCENTRATION (PROCESS); METABOLITES; PHARMACOKINETICS; PLASMAS; PROTEINS; REGRESSION ANALYSIS;

7Α-THIOMETHYLSPIROLACTONES; CANRENONES; CHILDREN; SPIRONOLACTONES;

KETONES;

7ALPHA THIOMETHYLSPIROLACTONE; CANRENONE; DRUG METABOLITE; SPIRONOLACTONE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD ANALYSIS; CALCULATION; CHILD; CONTROLLED STUDY; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFANT; MAJOR CLINICAL STUDY; PEDIATRICS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLING; SOLID PHASE EXTRACTION; STANDARD; VALIDATION PROCESS;

CANRENONE; CASE-CONTROL STUDIES; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPIRONOLACTONE; TIME FACTORS;

EID: 33745957763     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.02.017     Document Type: Article

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