Tolerance to morphine analgesia: Evidence for stimulus intensity as a key factor and complete reversal by a glycine site-specific NMDA antagonist

Neuropharmacology

Volumn 51, Issue 2, 2006, Pages 191-202

  Adam, Frédéric ^a,c   Bonnet, Francis ^d   Le Bars, Daniel ^a,b  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c HÔPITAL AMBROISE PARÉ   (France)

^d HÔPITAL TENON   (France)

Author keywords

(+) HA966; Analgesia; Morphine; NMDA; Reflex; Tolerance

Indexed keywords

3 AMINO 1 HYDROXY 2 PYRROLIDINONE; ANALGESIC AGENT; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OPIATE AGONIST;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG TOLERANCE; ELECTROSTIMULATION; HYPOTENSION; MALE; NERVE FIBER C; NERVE STIMULATION; NEUROPHARMACOLOGY; NONHUMAN; PAIN THRESHOLD; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE;

ANALGESICS, OPIOID; ANIMALS; BLOOD PRESSURE; DRUG TOLERANCE; ELECTRIC STIMULATION; HEART RATE; INJECTIONS, INTRAVENOUS; MALE; MORPHINE; NERVE FIBERS, UNMYELINATED; PAIN; PAIN THRESHOLD; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; REFLEX; STEREOISOMERISM; SURAL NERVE;

EID: 33745938930     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.03.018     Document Type: Article

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