Tibolone exerts progestational inhibition of matrix metalloproteinase expression in human endometrial stromal cells

Steroids

Volumn 71, Issue 9, 2006, Pages 768-775

  Schatz, Frederick ^a   Kuczynski, Edward ^a   Kloosterbooer, Lenus ^b   Krikun, Graciela ^a   Buchwalder, Lynn F ^a   Rahman, Mizanur ^a   Lockwood, Charles J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NV ORGANON   (Netherlands)

Author keywords

Endometrium; Matrix metalloproteinases; Progestin; Tibolone

Indexed keywords

3ALPHA HYDROXYTIBOLONE; 3BETA HYDROXYTIBOLONE; DELTA4 TIBOLONE; DRUG METABOLITE; ESTRADIOL; ESTROGEN RECEPTOR; GELATINASE A; GESTAGEN; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MEDROXYPROGESTERONE ACETATE; MESSENGER RNA; PROGESTERONE RECEPTOR; STEROID; STROMELYSIN; TIBOLONE; UNCLASSIFIED DRUG;

ARTICLE; CELL SECRETION; CONTROLLED STUDY; DRUG METABOLISM; ENDOMETRIUM CELL; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; HYPOTHESIS; INCUBATION TIME; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEROID BINDING; STEROID METABOLISM; STROMA CELL; WESTERN BLOTTING; ZYMOGRAPHY;

CELLS, CULTURED; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MATRIX METALLOPROTEINASES; NORPREGNENES; PROGESTINS; STROMAL CELLS;

EID: 33745933717     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2006.05.006     Document Type: Article

References (43)

1. Kloosterboer H.J. Tissue-selectivity: the mechanism of action of tibolone. Maturitas 48 Suppl. 1 (2004) S30-S40 (review)
2. Tax L., Goorissen E.M., and Kicovic P.M. Clinical profile of tibolone. Maturitas Suppl. 1 (1987) 3-13
3. von Schoultz B. The effects of tibolone and oestrogen-based HT on breast cell proliferation and mammographic density. Maturitas 49 1 (2004) S16-S21 (review)
4. Valdivia I., Campodonico I., Tapia A., Capetillo M., Espinoza A., and Lavin P. Effects of tibolone and continuous combined hormone therapy on mammographic breast density and breast histochemical markers in postmenopausal women. Fertil Steril 81 3 (2004) 617-623
5. Kenemans P., Speroff L., and International Tibolone Consensus Group. Tibolone: clinical recommendations and practical guidelines. A report of the International Tibolone Consensus Group. Maturitas 16 51 (2005) 21-28
6. Doren M., Rubig A., Coelingh Bennink H.J., and Holzgreve W. Impact on uterine bleeding and endometrial thickness: tibolone compared with continuous combined estradiol and norethisterone acetate replacement therapy. Menopause 6 4 (1999) 299-306
7. Kloosterboer H.J., and Ederveen A.G. Pros and cons of existing treatment modalities in osteoporosis: a comparison between tibolone, SERMs and estrogen (± progestogen) treatments. J Steroid Biochem Mol Biol 83 (2003) 157-165
8. de Gooyer M.E., Deckers G.H., Schoonen W.G., Verheul H.A., and Kloosterboer H.J. Receptor profiling and endocrine interactions of tibolone. Steroids 68 (2003) 21-30
9. Vos R.M., Krebbers S.F., Verhoeven C.H., and Delbressine L.P. The in vivo human metabolism of tibolone. Drug Metab Dispos 30 2 (2002) 106-112
10. Rymer J.M. The effects of tibolone. Gynecol Endocrinol 12 3 (1998) 213-220
11. Bell S.C. Decidualization and relevance to menstruation. In: D'Arcangues C., Fraser I.S., Newton J.R., and Odlind V. (Eds). Contraception and mechanisms of endometrial bleeding (1990), Cambridge University Press, Cambridge 188
12. Aplin J.D. Cellular biology of the endometrium. In: Wynn R.M., and Jolie W.P. (Eds). Biology of the uterus. 3rd ed. (1988), Plenum Press, New York, NY 187-202
13. Wewer U.M., Faber M., Liotta L.A., and Albrechtsen R. Immunochemical and ultrastructural assessment of the nature of the pericellular basement membrane of human decidual cells. Lab Invest 53 (1985) 624-633
14. Church H.J., Vicovac L.M., Williams J.D.L., Hey N.A., and Aplin J.D. Laminins 2 and 4 are expressed by human decidual cells. Lab Invest 74 (1996) 21-32
15. Birkedal-Hansen H., Moore W.G., Bodden M.K., Windsor L.J., Birkedal-Hansen B., DeCarlo A., et al. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4 (1993) 197-250
16. Rodgers W.H., Matrisian L.M., Giudice L.C., Dsupin B., Cannon P., Svitek C., et al. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest 94 (1994) 946-953
17. Schatz F., Papp C., Toth-Pal E., and Lockwood C.J. Ovarian steroid-modulated stromelysin-1 expression in human endometrial stromal and decidual cells. J Clin Endocrinol Metab 78 (1994) 1467-1472
18. Lockwood C.J., Krikun G., Hausknecht V.A., Papp C., and Schatz F. Matrix metalloproteinase and matrix metalloproteinase inhibitor expression in endometrial stromal cells during progestin-initiated decidualization and menstruation-related progestin withdrawal. Endocrinology 139 (1998) 4607-4613
19. Keller N.R., Sierra-Rivera E., Eisenberg E., and Osteen K.G. Progesterone exposure prevents matrix metalloproteinase-3 (MMP-3) stimulation by interleukin-1alpha in human endometrial stromal cells. J Clin Endocrinol Metab 85 (2000) 1611-1619
20. Salamonsen L.A., Butt A.R., Hammond F.R., Garcia S., and Zhang J. Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation. J Clin Endocrinol Metab 82 5 (1997) 1409-1415
21. Eckert R.L., and Katzenellenbogen B.S. Human endometrial cells in primary tissue culture: modulation of the progesterone receptor levels by natural and synthetic estrogens in vitro. J Clin Endocrinol Metab 52 4 (1981) 699-708
22. Noyes R.W., Hertig A.T., and Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol 122 2 (1975) 262-263
23. Lockwood C.J., Nemerson Y., Guller S., Krikun G., Alvarez M., Hausknecht V., et al. Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization. J Clin Endocrinol Metab 76 (1993) 231-236
24. Arcuri F., Monder C., Lockwood C.J., and Schatz F. Expression of 11β-hydroxysteroid dehydrogenase during decidualization of human endometrial stromal cells. Endocrinology 137 (1996) 595-599
25. Markiewicz L., and Gurpide E. In vitro evaluation of estrogenic, estrogen antagonistic and progestagenic effects of a steroidal drug (Org OD-14) and its metabolites on human endometrium. J Steroid Biochem 35 5 (1990) 535-541
26. Markiewicz L., Hochberg R.B., and Gurpide E. Intrinsic estrogenicity of some progestagenic drugs. J Steroid Biochem Mol Biol 41 1 (1992) 53-58
27. Wen D.X., Xu Y.F., Mais D.E., Goldman M.E., and McDonnell D.P. The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol 14 12 (1994) 8356-8364
28. Sartorius C.A., Shen T., and Horwitz K.B. Progesterone receptors A and B differentially affect the growth of estrogen-dependent human breast tumor xenografts. Breast Cancer Res Treat 79 3 (2003) 287-299
29. Taylor AH, McParland PC, Taylor DJ, Bell SC. The progesterone receptor in human term amniochorion and placenta is isoform C. Endocrinology 2005; Epub 2005, October 27.
30. Luconi M., Bonaccorsi L., Maggi M., Pecchioli P., Krausz C., Forti G., et al. Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane. J Clin Endocrinol Metab 83 3 (1998) 877-885
31. Duffy D.M., Molskness T.A., and Stouffer R.L. Progesterone receptor messenger ribonucleic acid and protein in luteinized granulosa cells of rhesus monkeys are regulated in vitro by gonadotropins and steroids. Biol Reprod 54 4 (1996) 888-895
32. Nagase H. Stromelysins 1 and 2. In: Parks W.C., and Mecham R. (Eds). Matrix metalloproteinases (1998), Academic Press, San Diego 43-84
33. Murphy G., Cockett M.I., Ward R.V., and Docherty A.J. Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP). Biochem J 277 (1991) 277-279
34. He C.S., Wilhelm S.M., Pentland A.P., Marmer B.L., Grant G.A., Eisen A.Z., et al. Tissue cooperation in a proteolytic cascade activating human interstitial collagenase. Proc Natl Acad Sci USA 86 8 (1989) 2632-2636
35. Ogata Y., Enghild J.J., and Nagase H. Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase. J Biol Chem 267 (1992) 3581-3584
36. Gaire M., Magbanua Z., McDonnell S., McNeil L., Lovett D.H., and Matrisian L.M. Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J Biol Chem 269 (1994) 2032-2040
37. Zhang J., Hampton A.L., Nie G., and Salamonsen L.A. Progesterone inhibits activation of latent matrix metalloproteinase (MMP)-2 by membrane-type 1 MMP: enzymes coordinately expressed in human endometrium. Biol Reprod 62 (2000) 85-94
38. Inaki N., Tsunezuka Y., Kawakami K., Sato H., Takino T., Oda M., et al. Increased matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase activity and expression in heterotopically transplanted murine tracheas. J Heart Lung Transplant 23 (2004) 218-227
39. Suzuki S., Sato M., Senoo H., and Ishikawa K. Direct cell-cell interaction enhances pro-MMP-2 production and activation in co-culture of laryngeal cancer cells and fibroblasts: involvement of EMMPRIN and MT1-MMP. Exp Cell Res 293 (2004) 259-266
40. McMahon S., Laprise M.H., and Dubois C.M. Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta. Exp Cell Res 29 (2003) 326-339
41. Schatz F., Kuczynski E., Kloosterboer H.J., Buchwalder L., Tang C., Krikun G., et al. Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: evidence of progestogenic effects. Steroids 70 12 (2005) 840-845
42. Nemerson Y. Tissue factor and hemostasis. Blood 71 (1988) 1-8
43. Mignatti P., and Rifkin D.B. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 73 (1993) 161-195