Induced peripheral nerve regeneration using scaffolds

Minerva Biotecnologica

Volumn 18, Issue 2, 2006, Pages 97-120

  Harley, B A ^a   Yannas, I V ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Peripheral nerve; Regeneration; Scaffold; Tissue engineering; Tube

Indexed keywords

ANTIBIOTIC AGENT; BIOMATERIAL; CHITOSAN; DIMETICONE; FIBRIN; HERBACEOUS AGENT; HORMONE; HYALURONIC ACID; IMMUNOSUPPRESSIVE AGENT; POLITEF; POLYCAPROLACTONE; POLYGLACTIN; POLYLACTIDE; SILICONE; VITAMIN;

BIOCOMPATIBILITY; CERAMIC PROSTHESIS; CHEMICAL COMPOSITION; EXTRACELLULAR MATRIX; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; MOTOR PERFORMANCE; NERVE CELL NECROSIS; NERVE FIBER GROWTH; NERVE REGENERATION; NERVE SUTURE; NERVE TRANSECTION; NERVE TRANSPLANTATION; NONHUMAN; PATHOLOGICAL ANATOMY; PERIPHERAL NERVE INJURY; PROCESS OPTIMIZATION; PROSTHESIS MATERIAL; QUALITY CONTROL; REVIEW; SCAR FORMATION; SENSORIMOTOR FUNCTION; SPINAL CORD TRANSSECTION; STANDARDIZATION; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; WOUND CONTRACTION; WOUND HEALING;

ANIMALIA; MAMMALIA;

EID: 33745914930     PISSN: 11204826     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (152)

1. Madison RD, Archibald SJ, Krarup C. Peripheral nerve injury. In: Lindblad WJ, editor. Wound healing: Biochemical and clinical aspects. Philadelphia: W.B. Saunders; 1992.p.45O-87.
2. Mackinnon SE, Dellon AL. Surgery of the peripheral nerve. New York; Thieme Medical Publishers; 1988.
3. Fields RD, LeBeau JM, Longo FM, Ellisman MH. Nerve regeneration through artificial tubular implants. Prog Neurobiol 1989;33: 87-134.
4. Yannas IV. Tissue and organ regeneration in adults. New York: Springer-Verlag; 2001.
5. Aebischer P, Salessiotis JM, Winn SR. Basic fibroblast growth factor released from synthetic guidance channels facilitates regeneration across long nerve gaps. J Neurosci Res 1989;23:282-9.
6. Hollowell JP, Villadiego A, Rich KM. Sciatic nerve regeneration across gaps within silicone chambers: long-term effects of NGF and consideration of axonal branching. Exp Neurol 1990;110:45-51.
7. Walter MA, Kurouglu R, Caulfield JB, Vasconez LO, Thompson JA. Enhanced peripheral nerve regeneration by acidic fibroblast growth factor. Lymphokine Cytokine Res 1993;12:35-41.
8. Bailey SB, Eichler ME, Villadiego A, Rich KM. The influence of fibronectin and laminin during Schwann cell migration and peripheral nerve regeneration through silicon chambers. J Neurocytol 1993;22:176-84.
9. Bryan DJ, Miller RA, Costas PD, Wang KK, Seckel BR. Immunohistochemistry os skeletal muscle basal lamina grafts in nerve regeneration. Plast Reconstr Surg 1993;92:927-40.
10. Chang AS, Yannas IV, Perutz S, Loree H, Sethi RR, Krarup C et al. Electrophysiological study of recovery of peripheral nerves regenerated by a collagen-glycosaminoglycan copolymer matrix. In: Dunn RL, editor. Progress in biomedical polymers. New York: Plenum Press; 1990.p.107-19.
11. Glasby MA, Gschmeissner SE, Huang CLH, de Souza BA. Degenerated muscle grafts used for peripheral nerve repair in primates. J Hand Surg 1986;11-B:347-51.
12. Madison RD, da Silva CF, Dikkes P. Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses. Brain Res 1988;447: 325-34.
13. Ohbayashi K, Inous HK, Awaya A, Kobayashi S, Kohga H, Nakamura M et al. Peripheral nerve regeneration in a silicone tube: effect of collagen sponge prosthesis, laminin, and pyrimidine compound administration. Neurol Med Chir 1996;36:428-33.
14. Rosen JM, Padilla JA, Nguyen KD, Padilla MA, Sabelman EE, Pham HN. Artificial nerve graft using collagen as an extracellular matrix for nerve repair composed with sutured autograft in a rat model. Ann Plast Surg 1990;25:375-87.
15. Yannas IV, Orgill DP, Silver J, Norregaard TV, Zervas NT, Schoene WC. Regeneration of sciatic nerve across 15 mm gap by use of a polymeric template. In: Gebelin CG, editor. Advances in biomedical polymers. New York: Plenum Publishing Corporation; 1987.p.1-9.
16. Yoshii S, Yamamuro T, Ito S, Hayashi M. In vivo guidance of regenerating nerve by laminin-coated filaments. Exp Neurol 1987;96:469-73.
17. Valentini RF, Aebischer P, Winn SR, Galletti PM. Collagen- and laminin-containing gels impede peripheral nerve regeneration through semipermeable nerve guidance channels. Exp Neurol 1987;98:350-6.
18. Labrador RO, Buti M, Navarro X. Influence of collagen and laminin gels concentration on nerve regeneration after resection and tube repair. Exp Neurol 1998;149:243-52.
19. Yannas IV, Orgill DP, Silver J, Norregaard TV, Zervas NT, Schoene WC. Polymeric template facilitates regeneration of sciatic-nerve across 15-mm gap. Abstracts of papers of the American Chemical Society 1985;190:44-Pme.
20. Williams LR, Danielsen N, Muller H, Varon S. Exogenous matrix precursors promote functional nerve regeneration across a 15-mm gap within a silicone chamber in the rat. J Comp Neurol 1987;264:284-90.
21. Lundborg G, Dahlin L, Dohi D, Kanje M, Terada N. A new type of "bioartificial" nerve graft for bridging extended defects in nerves. J Hand Surg (Br Eur) 1997;22B:299-303.
22. Chamberlain LJ, Yannas IV, Hsu HP, Strichartz G, Spector M. Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft. Exp Neurol 1998;154:315-29.
23. Guenard V, Kleitman N, Morrissey TK, Bunge RP, Aebischer P. Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration. J Neurosci 1992;12:3310-20.
24. Morrissey TK, Kleitman N, Bunge RP. Isolation and functional characterization of schwann cells derived from adult peripheral nerve. J Neurosci 1991;11:2433-42.
25. Kim DH, Connolly SE, Kline DG, Voorhies RM, Smith A, Powell M et al. Labeled Schwann cell transplants versus sural nerve grafts in nerve repair. J Neurosurg 1994;80:254-60.
26. Ansselin AD, Fink T, Davey DF. Peripheral nerve regeneration through nerve guides seeded with adult Schwann cells. Neuropathol Appl Neurobiol 1997;23:387-98.
27. Rodriguez FJ, Verdu E, Ceballos D, Navarro X. Nerve guides seeded with autologous Schwann cells improve nerve regeneration. Exp Neurol 2000;161;571-84.
28. Ducker TB, Hayes GJ. Experimental improvements in the use of silastic cuff for peripheral nerve repair. J Neurosurg 1968;28: 582-7.
29. Seckel BR, Chiu TH, Nyilas E, Sidman RL. Nerve regeneration through synthetic biodegradable nerve guides: regulation by the target organ. Plast Reconstr Surg 1984;74:173-81.
30. den Dunnen WFA, Schakenraad JM, Zondervan GJ, Pennings AJ, van der Lei B, Robinson PH. A new PLLA/PCL copolymer for nerve regeneration. J Mater Sci Mater Med 1993;4:521-5.
31. Jenq CB, Coggeshall RE. Permeable tubes increase the length of the gap that regenerating axons can span. Brain Res 1987;408: 239-42.
32. Aebischer P, Guenard V, Winn SR, Valentini RF, Galletti PM. Blind-ended semipermeable guidance channels support peripheral nerve regeneration in the absence of a distal nerve stump. Brain Res 1988;454:179-87.
33. Li ST, Archibald SJ, Krarup C, Madison RD. Peripheral nerve repair with collagen conduits. Clin Mater 1992;9:195-200.
34. Li S-T, Archibald SJ, Krarup C, Madison SD. Semipermeable collagen nerve conduits for peripheral nerve regeneration. Polym Mater Sci Eng 1990;62:575-82.
35. Aldini NN, Perego G, Cella GD, Martarello MC, Fini M, Rocca M et al. Effectiveness of a bioabsorbable conduit in the repair of peripheral nerves. Biomaterials 1996;17:959-62.
36. Harley BA. Peripheral nerve regeneration through collagen devices with different in vivo degradation characteristics. M.S. Thesis, Massachusetts Institute of Technology; 2002.
37. Harley BA, Spilker MH, Wu JW, Asano K, Hsu HP, Spector M et al. Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps. Cells Tissues Organs 2004;176:153-65.
38. Robinson PH, van der Lei B, Hoppen HJ, Leenslag JW, Pennings AJ, Nieuwenhuis P. Nerve regeneration through a two-ply biodegradable nerve guide in the rat and the influence of ACTH4-9 nerve growth factor. Microsurgery 1991;12:412-9.
39. Tountas CP, Bergman RA, Lewis TW, Stone HE, Pyrek JD, Mendenhall HV. A comparison of peripheral nerve repair using an absorbable tubulization device and conventional suture in primates. J Appl Biomater 1993;4:261-8.
40. Mast BA, Diegelmann RF, Krummel TM, Cohen IK. Scarless wound healing in the mammalian fetus. Surg Gynecol Obstet 1992;174: 441-51.
41. Mast BA, Nelson JM, Krummel TM. Tissue repair in the mammalian fetus. In: Cohen IK, Diegelmann RF, Lindblad WJ, editors. Wound healing: biochemical and clinical aspects. Philadelphia: W.B. Saunders; 1992.p.326-41.
42. Yannas IV. In vitro synthesis of tissues and organs. In: Lanza RP, Langer R, Vacanti J, editors. Principles of tissue engineering. San Diego: Academic Press; 2000.p.857.
43. Yannas IV, Lee E, Orgill DP, Skrabut EM, Murphy GF. Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin. Proc Natl Acad Sci U S A 1989;86:933-7.
44. Martinez-Hernandez A. Repair, regeneration, and fibrosis. In: Rubin E, Faber JL, editors. Pathology. Philadelphia: J.B. Lippincott; 1988.p.66-95.
45. Bunge RP, Bunge MB. Interrelationship between Schwann cell function and extracellular matrix production. Trends Neurosci 1983;6:499-505.
46. Chamberlain LJ. Influence of implant parameters on the mechanisms of peripheral nerve regeneration. Ph.D. Thesis. Mechanical Engineering, Massachusetts Institute of Technology; 1998.
47. Uitto J, Mauviel A, McGrath J. The dermal-epidermal basement membrane zone in cutaneous wound healing. In: Clark RAF, editor. The molecular and cellular biology of wound repair, 2nd ed. New York: Plenum Press; 1996.p.513-60.
48. Fu SY, Gordon T. The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol 1997;14:67-116.
49. Haber RM, Hanna W, Ramsay CA, Boxall LB. Cicatricial junctional epidermolysis bullosa. J Am Acad Dermatol 1985;12:836-44.
50. Ikeda K, Oda Y, Tomita K, Nomura S, Nakanishi I. Isolated Schwann cells can synthesize the basement membrane in vitro. J Electron Microsc (Tokyo) 1989;38:230-4.
51. Stenn KS, Malhotra R. Epithelialization. In: Cohen IK, Diegelmann RF, Lindblad WJ, editor. Wound healing: biochemical and clinical aspects. Philadelphia: W. B. Saunders; 1992.p.115-27.
52. Ferdman AG, Yannas IV. Scattering of light from histologic section: a new method for the analysis of connective tissue. J Invest Dermatol 1993;100:710-6.
53. Lehv M, Fitzgerald PJ. Pancreatic acinar cell regeneration IV: regeneration after surgical resection. Am J Pathol 1968;53:513-35.
54. Oliver J. Correlations of structure and function and mechanisms of recovery in acute tubular necrosis. Am J Med 1953;15:535-57.
55. Stemerman MB, Spaet TH, Pitlick F, Cintron J, Lejnieks I, Tiell ML. Intimal healing. The patterns of reendothelialization and intimal thickening. Am J Pathol 1977;87:125-42.
56. Vracko R. Significance of basal lamina for regeneration of injured lung. Virchows Arch (Pathol Anat) 1972;355:264-74.
57. Geren BB. The formation from the Schwann cell surface of myelin in the peripheral nerves of chick embryos. Exp Cell Res 1954;7:558.
58. Robertson JD. The molecular structure and contact relationships of cell membranes. Prog Biophys 1960;10:343.
59. Aidley DJ. The physiology of excitable cells. Cambridge, U.K.: Cambridge University Press; 1971.
60. Rosen JM, Hentz VR, Kaplan EN. Fascicular tubulization: a cellular approach to peripheral nerve repair. Ann Plast Surg 1983;11:397-411.
61. Bradley JL, Abernathy DA, King RHM, Muddle JR, Thomas PK. Neural architecture in transected rabbit sciatic nerve after prolonged nonreinnervation. J Anat 1998;192:529-38.
62. Thomas PK, Olsson Y. Microscopic anatomy and function of the connective tissue components of peripheral nerve. In: Dyck PJ, Thomas PK, Lambert EH, editors. Peripheral neuropathy. Philadelphia: W.B. Saunders; 1975.p.168-89.
63. Lisney SJW. Regeneration of unmyelinated axons after injury of mammalian peripheral nerve. J Exp Phys 1989;74:757-84.
64. Lanza RP, Langer R, Chick WL, editors. Principles of tissue engineering. San Diego: Academic Press; 1997.
65. Harley BA, Yannas IV. Skin, tissue engineering for regeneration. In: Webster JG, editor. Wiley encyclopedia of medical devices and instrumentation. New York: John Wiley & Sons; 2006.
66. Wickelgren I. Muscling transplants in mice. Science 1996;273:33.
67. Lanza RP, Cooper DK, Chick WL. Xenotransplantation. Sci Am 1997;277:54-9.
68. Medawar PB. The behavior and fate of skin autografts and skin homografts in rabbits. J Anat 1944;78:176-99.
69. Rudolph R, Van de Berg J, Ehrlich P. Wound contraction and scar contracture. In: Cohen IK, Diegelmann RF, Lindblad WJ, editors. Wound healing: biochemical and clinical aspects. Philadelphia: W.B. Saunders; 1992.p.96-114.
70. Spector M, Heyligers I, Roberson JR. Porous polymers for biological fixation. Clin Orth 1993;235:207-19.
71. Snyder TA, Watach MJ, Litwak KN, Wagner WR. Platelet activation, aggregation, and life span in calves implanted with axial flow ventricular assist devices. Ann Thorac Surg 2002;73:1933-8.
72. Urban RM, Jacobs JJ, Tomlinson MJ, Gavrilovic J, Black J, Peoc'h M. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip and knee replacement. J Bone Joint Surg Am 2000;82:457-76.
73. Willert HG. Reactions of the articular capsule to wear products of artificial joint prostheses. J Biomed Mater Res 1977;11:157-64.
74. Pittenger MF, Mackay AM, Berk SC, Jaiswal RK, Douglas R, Mosca JD et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
75. Slack JM. Stem cells in epithelial tissues. Science 2000;287:1431-3.
76. Gage FH. Mammalian neural stem cells. Science 2000;287:1433-8.
77. Rabkin-Aikawa E, Mayer JE, Schoen EJ. Heart valve regeneration. In: Yannas IV, editor. Regenerative medicine II. Berlin: Springer; 2005.p.141-79.
78. Yannas IV. Synthesis of organs: in vitro or in vivo? Proceedings of the National Academy of Sciences of the United States of America 2000;97:9354-6.
79. Yannas IV, Burke JF, Huang C, Gordon PL. Suppression of in vivo degradability and of immunogenicity of collagen by reaction with glycosaminoglycans. Polym Prepr Am Chem Soc 1975;16:209-14.
80. Burke JF, Yannas IV, Quinby WC Jr, Bondoc CC, Jung WK. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg 1981;194:413-28.
81. Yannas IV. Use of artificial skin in wound management. In: Dineen P, editor. The Surgical Wound. Philadelphia: Lea & Febiger; 1981.p.171-90.
82. Yannas IV, Burke JF. Design of an artificial skin I: basic design principles. J Biomed Mater Res 1980;14:65-81.
83. Yannas IV, Burke JF, Huang C, Gordon PL. Multilayer membrane useful as synthetic skin. Patent 4,060,081 4,060,081, USA.
84. Yannas IV, Burke JF, Warpehoski M, Stasikelis P, Skrabut EM, Orgill DP et al. Prompt, long-term functional replacement of skin. Trans Am Soc Artif Intern Organs 1981;27:19-22.
85. Yannas IV, Burke JF, Orgill DP, Skrabut EM. Wound tissue can utilize a polymeric template to synthesize a functional extension of skin. Science 1982;215:174-6.
86. Yannas IV, Orgill DP, Skrabut EM, Burke JF. Skin regeneration with a bioreplaceable polymeric template. In: Gebelein CC, editor. Polymeric materials and artificial organs. Washington, D.C.: American Chemical Society; 1984.p.191-7.
87. Yannas IV. Models of organ regeneration processes induced by templates. In: Cherrington AD, editor. Bioartificial organs. Annals of the New York Academy of Sciences 1997.p.280-93.
88. Yannas IV. Facts and theories of induced organ regeneration. Adv Biochem Eng Biotechnol 2005;93:1-31.
89. Yannas IV. Artificial skin and dermal equivalents. In: Bronzio JD, editor. The biomedical engineering handbook. Boca Raton: CRC Press; 2000.p.138-1 to -15.
90. Williams LR, Longo FM, Powell HC, Lundborg G, Varon S. Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. J Comp Neurol 1983;218:460-70.
91. Yannas IV, Burke JF, Huang C, Gordon PL. Correlation of in vivo collagen degradation rate with in vitro measurements. J Biomed Mater Res 1975;9:623-8.
92. Chang AS, Yannas IV. Peripheral nerve regeneration. In: Smith B, Adelman G, editors. Encyclopedia of neuroscience. Boston: Birkhauser; 1992.p.125-6.
93. Yannas IV. Regeneration templates. In: Bronzio JD, editor. The biomedical engineering handbook. Boca Raton: CRC Press; 2000.p.113-1 to -18.
94. Yannas IV, Tobolsky AV. Cross linking of gelatine by dehydration. Nature 1967;215:509-10.
95. Yannas IV, Burke JF, Gordon PL, Huang C, Rubenstein RH. Design of an artificial skin II: control of chemical-composition. J Biomed Mater Res 1980;14:107-32.
96. Lee JE, Park JC, Hwang YS, Kim JK, Kim JG, Sub H. Characterization of UV-irradiated dense/porous collagen membranes: morphology, enzymatic degradation, and mechanical properties. Yonsei Med J 2001;42:172-9.
97. Lee CR, Grodzinsky AJ, Spector M. The effects of crosslinking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation, and biosynthesis. Biomaterials 2001;22:3145-54.
98. Lee CR, Breinan HA, Nehrer S, Spector M. Articular cartilage chondrocytes in type I and type II collagen-GAG matrices exhibit contractile behavior in vitro. Tissue Eng 2000;6:555-65.
99. Olde Damink LHH, Dijkstra PJ, van Luyn MJA, Van Wachem PB, Nieuwenhuis P, Feijen J. Cross-linking of dermal sheep collagen using a water soluble carbodiimide. Biomaterials 1996;17: 765-73.
100. Freyman TM, Yannas IV, Gibson LJ. Cellular materials as porous scaffolds for tissue engineering. Prog Mat Sci 2001;46:273-82.
101. Schoof H, Apel J, Heschel I, Rau G. Control of pore structure and size in freeze-dried collagen sponges. J Biomed Mater Res 2001;58:352-7.
102. Yannas IV. Biologically-active analogs of the extracellular-matrix: artificial skin and nerves. Angewandte Chemie: International Edition in English 1990;29:20-35.
103. Howe A, Aplin AE, Alahari SK, Juliano RL. Integrin signaling and cell growth control. Curr Opin Cell Biol 1998;10:220-31.
104. van Tienen TG, Heijkants RGJC, Buma P, de Groot JH, Pennings AJ, Veth RPH. Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizes. Biomaterials 2002;23:1731-8.
105. O'Brien FJ, Harley BA, Yannas IV, Gibson LJ. The effect of pore size on cell adhesion in collagen-GAG scaffolds. Biomaterials 2005;26:433-41.
106. Gibson LJ, Ashby MF. Cellular solids: structure and properties. In: Clarke DR, Suresh S, Ward IM, editors. Cambridge solid state science series. Cambridge, U.K.: Cambridge University Press; 1997.p.175-234.
107. Yannas IV. Studies on the biological activity of the dermal regeneration template. Wound Rep Regen 1998;6:518-24.
108. Harley BA, Yannas IV, Gibson LJ. Mechanical characterization of a homologous series of equiaxed collagen-GAG scaffolds. In preparation, 2005.
109. Lo CM, Wang HB, Dembo M, Wang YL. Cell movement is guided by the rigidity of the substrate. Biophys J 2000;79:144-52.
110. Orgill DP, Butler CE, Reagan JF. Behavior of collagen-GAG matrices as dermal replacements in rodent and porcine models. Wounds 1996;8:151-7.
111. Yannas IV. Regeneration templates. In: Bronzino JD, editor. The biomedical Engineering handbook. New York: CRC Press; 1995.p.1619-35.
112. Chamberlain LJ, Yannas IV. Preparation of collagen-glycosaminoglycan copolymers for tissue regeneration. In: Morgan JR, Yarmush ML, editors. Methods of molecular medicine, vol. 20. Totowa, NJ: Humana Press; 1998.p.3-17.
113. Chamberlain LJ, Yannas IV, Hsu HP, Spector M. Connective tissue response to tubular implants for peripheral nerve regeneration: the role of myofibroblasts. J Comp Neurol 2000;417:415-30.
114. Chamberlain LJ, Yannas IV, Hsu HP, Strichartz GR, Spector M. Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap. J Neurosci Res 2000;60:666-77.
115. Hsu WC, Spilker MH, Yannas IV, Rubin PA. Inhibition of conjunctival scarring and contraction by a porous collagen-glycosaminoglycan implant. Invest Ophthalmol Vis Sci 2000;41:2404-11.
116. Billingham RE, Medawar PB. Contracture and intussusceptive growth in the healing of expensive wounds in mammalian skin. J Anat 1955;89:114-23.
117. Wall PD, Devor M, Inbal R, Scadding JW, Schonfeld D, Seltzer Z et al. Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa. Pain 1979;7:103-13.
118. Carr MM, Best TJ, Mackinnon SE, Evans PJ. Strain differences in autotomy in rats undergoing sciatic nerve transection or repair. Ann Plast Surg 1992;28:538-44.
119. Haftek J, Thomas PK. Electron-microscope observations on the effects of localized crush injuries on the connective tissues of peripheral nerve. J Anat 1968;103(Pt 2):233-43.
120. Walker JL, Evans JM, Resig P, Guarnieri S, Meade P, Sisken BS. Enhancement of functional recovery following a crush lesion to the rat sciatic nerve by exposure to pulsed electromagnetic fields. Exp Neurol 1994;125:302-5.
121. Korompilias AV, Chen LE, Seaber A, Urbaniak JR. Interleukin-1 beta promotes functional recovery of crushed peripheral nerve. J Orthop Res 1999;17:714-9.
122. Lundborg G, Dahlin LB, Danielsen N, Gelberman RH, Longo FM, Powell HC et al. Nerve regeneration in silicone chambers: Influence of gap length and of distal stump components. Exp Neurol 1982;76:361-75.
123. Spilker MH. Peripheral nerve regeneration through tubular devices: a comparison of assays of device effectiveness. Ph.D. Thesis. Mechanical Engineering, Massachusetts Institute of Technology; 2000.
124. Archibald SJ, Shefner J, Krarup C, Madison RD. Monkey median nerve repaired by nerve graft or collagen nerve guide tube. J Neurosci 1995;15(5 Pt 2):4109-23.
125. Chang AS, Yannas IV, Krarup C, Sethi R, Norregaard TV, Zervas NT. Polymeric templates for peripheral-nerve regeneration - electrophysiological study of functional recovery. Abstracts of papers of the American Chemical Society 1988;196:193-Pmse.
126. den Dunnen WFA, Stokroos I, Blaauw EH, Holwerda A, Pennings AJ, Robinson PH et al. Light microscopic and electron-microscopic evaluation of short term nerve regeneration using a biodegradable poly(DL-lactide-0-caprolacton) nerve guide. J Biomed Mater Res 1996;31:105-15.
127. Jenq CB, Coggeshall RE. Effects of sciatic nerve regeneration on axonal popoulations in tributary nerves. Brain Res 1984;295:91-100.
128. Meek MF, Robinson PH, Stokroos I, Blaauw EH, Kors G, den Dunnen WF. Electronmicroscopical evaluation of short-term nerve regeneration through a thin-walled biodegradable poly(DLLA-epsilon-CL) nerve guide filled with modified denatured muscle tissue. Biomaterials 2001;22:1177-85.
129. Navarro X, Rodriguez FJ, Labrador RO, Buti M, Ceballos D, Gomez N et al. Peripheral nerve regeneration through bioresorbable and durable nerve guides. J Peripher Nerv Syst 1996;1:53-64.
130. Williams LR, Powell HC, Lundborg G, Varon S. Competence of nerve tissue as distal insert promoting nerve regeneration in a silicone chamber. Brain Res 1984;293:201-11.
131. den Dunnen WFA, van der Lei B, Schakenraad JM, Blaauw EH, Stokroos I, Pennings AJ et al. Long-term evaluation of nerve regeneration in a biodegradable nerve guide. Microsurgery 1993;14: 508-15.
132. Jenq CB, Jenq LL, Coggeshall RE. Nerve regeneration changes with filters of different pore sizes. Exp Neurol 1987;97:662-71.
133. Jenq CB, Coggeshall RE. Numbers of regenerating axons in parent and tributary peripheral nerves in the rat. Brain Res 1985;326: 29-40.
134. Williams LR. Exogenous fibrin matrix precursors stimulate the temporal progress of nerve regeneration within a silicone chamber. Neurochem Res 1987;12:851-60.
135. Lundborg G, Dahlin LB, Danielsen N, Johannesson A, Hansson HA, Longo F et al. Nerve regeneration across an extended gap: a neuronobiological view of nerve repair and the possible involvement of neuronotrophic factors. J Hand Surg 1982;7:580-7.
136. Archibald SJ, Krarup C, Shefner J, Li ST, Madison RD. A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. J Comp Neurol 1991;306:685-96.
137. Madison RD, da Silva CF, Dikkes P, Chiu TH, Sifman RL. Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. Exp Neurol 1985;88:762-77.
138. Gulati AK. Evaluation of acellular and cellular nerve grafts in repair of rat peripheral nerve. J Neurosurg 1988;68:117-23.
139. Jenq CB, Coggeshall RE. Numbers of regenerated axons in tributary nerves following neonatal sciatic nerve crush in rat. Neurosci Lett 1985;61:43-8.
140. Jenq CB, Coggeshall RE. Nerve regeneration through holey silicone tubes. Brain Res 1985;361:233-41.
141. Rodriguez FJ, Gomez N, Perego G, Navarro X. Highly permeable polylactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps. Biomaterials 1999;20:1489-500.
142. Kim DH, Connolly SE, Zhao S, Beuerman RW, Voorhies RM, Kline DG. Comparison of macropore, semipermeable, and nonpermeable collagen conduits in nerve repair. J Reconstr Microsurg 1993;9:415-20.
143. Chamberlain LJ, Yannas IV, Arrizabalaga A, Hsu HP, Norregaard TV, Spector M. Early peripheral nerve healing in collagen and silicone tube implants: myofibroblasts and the cellular response. Biomaterials 1998;19:1393-403.
144. Mohammad J, Shenaq J, Rabinovsky E, Shenaq S. Modulation of peripheral nerve regeneration: a tissue-engineering approach. The role of amnion tube nerve conduit across a 1-cm nerve gap. Plast Reconstr Surg 2000;105:660-6.
145. Wang S, Wan AC, Xu X, Gao S, Mao HQ, Leong KW et al. A new nerve guide conduit material composed of a biodegradable poly(phosphoester). Biomaterials 2001;22:157-69.
146. Itoh S, Takakuda K, Ichinose S, Kikuchi M, Schinomiya K. A study of induction of nerve regeneration using bioabsorbable tubes. J Reconstr Microsurg 2001;17:115-23.
147. Valero-Cabre A, Tsironis K, Skouras E, Perego G, Navarro X, Neiss WF. Superior muscle reinnervation after autologous nerve graft or poly-L-lactide-epsilon-caprolactone (PLC) tube implantation in comparison to silicone tube repair. J Neurosci Res 2001;63:214-23.
148. Molander H, Engkvist O, Hagglund J, Olsson Y, Torebjork E. Nerve repair using a polyglactin tube and nerve graft: An experimental study in the rabbit. Biomaterials 1983;4:276-80.
149. Borkenhagen M, Stoll RC, Neuenschwander P, Suter UW, Aebischer P. In vivo performance of anew biodegradable polyester urethane system used as a nerve guidance channel. Biomaterials 1998;19:2155-65.
150. Huang C, Yannas IV. Mechanochemical studies of enzymatic degradation of insoluble collagen fibers. J Biomed Mater Res 1977;11:137-54.
151. Weiss P. The technology of nerve regeneration: a review: sutureless tubulation and related methods of nerve repair. J Neurosurg 1944;1:400-50.
152. Zhao Q, Dahlin LB, Kanje M, Lundborg G. The formation of a 'pseudonerve' in silicone chambers in the absence of regenerating axons. Brain Res 1992;592:106-14.