99mTc-Fanolesomab: Affinity, pharmacokinetics and preliminary evaluation

Quarterly Journal of Nuclear Medicine and Molecular Imaging

Volumn 50, Issue 2, 2006, Pages 104-112

  Shanthly, N ^a   Aruva, M R ^a   Zhang, K ^a   Mathew, B ^a   Thakur, Mathew L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Anti SSEA 1; Monoclonal antibodies; NeutroSpec

Indexed keywords

CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY I 123; CD15 ANTIGEN; FANOLESOMAB TC 99M; GALLIUM CITRATE GA 67; HUMAN IMMUNOGLOBULIN IN 111; HUMAN IMMUNOGLOBULIN TC 99M; INDIUM 111; INTERLEUKIN 1 I 123; PENTETATE INDIUM IN 111; PENTETATE TECHNETIUM TC 99M; RADIOPHARMACEUTICAL AGENT; SULESOMAB TC 99M; TECHNETIUM 99M; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY ANTI SSEA 1; MONOCLONAL ANTIBODY ANTI-SSEA-1;

ABSCESS; ANAPHYLAXIS; ANTIGEN EXPRESSION; BACTERIAL INFECTION; CELL LABELING; CLINICAL TRIAL; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DOSE RESPONSE; DRUG ACCUMULATION; DRUG APPROVAL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXCRETION; DRUG FATALITY; DRUG HALF LIFE; DRUG PREFERENCE; DRUG SAFETY; DRUG TISSUE LEVEL; DRUG UPTAKE; FOOD AND DRUG ADMINISTRATION; GRANULOCYTOPENIA; HUMAN; IMMUNOSCINTIGRAPHY; ISOTOPE LABELING; LEUKOCYTE; LEUKOPENIA; OSTEOMYELITIS; PHLEGMON; REVIEW; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOFT TISSUE INFECTION; ANIMAL; DRUG SCREENING; INFECTION; METABOLISM; METHODOLOGY; NEUTROPHIL; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING;

ANIMALS; ANTIBODIES, MONOCLONAL; CLINICAL TRIALS; DRUG EVALUATION, PRECLINICAL; HUMANS; INFECTION; NEUTROPHILS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 33745910527     PISSN: 18244785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL. Harrison's principles of internal medicine, 16th ed. New York, NY: The McGraw-Hill Companies; 2005.
2. 99mTc-labeled leukocytes and polyclonaland monoclona antibodies. Semin Nucl Med 1996;26:51-64.
3. Rolandelli R, Roslyn JJ. Surgical management and treatment of sepsis associated with gastrointestinal fistulas. Surg Clin North Am 1996;76:1111-22.
4. Lavender JP, Lowe J, Baker JR, Chaudri MA. Gallium-67 citrate scanning in neoplastic and inflammatory lesions. Br J Radiol 1971;44:361-6.
5. Oster MW, Gelrud LG, Lotz MJ, Herzig GP, Johnston GS. Psoas abscess localization by gallium scan in aplastic anemia. JAMA 1975;232:377-9.
6. Deysine M, Rafkin H, Teicher I, Silver L, Robinson R, Manly J et al. Diagnosis of chronic and postoperative osteomyelitis with gallium 67 citrate scans. Am J Surg 1975;129:632-5.
7. Coopersmith A, Ritchey AK, Zinkham WH. Fever of unknown origin and the value of gallium-67 and technetium-99M for defining abnormality of the spleen: a case report. Johns Hopkins Med J 1975;137:51-4.
8. Thakur ML. Gallium-67 and indium-111 radiopharmaceuticals. Int J Appl Radiat Isot 1977;28:183-201.
9. Chianelli M, Mather SJ, Martin-Comin J, Signore A. Radiopharmaceuticals for the study of inflammatory processes: a review. Nucl Med Commun 1997;18:437-55.
10. Thakur ML, Coleman RE, Welch MJ. Indium-111-labeled leukocytes for the localization of abscesses: preparation, analysis, tissue distribution, and comparison with gallium-67 citrate in dogs. J Lab Clin Med 1977;89:217-28.
11. Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW. Indium-111-labeled autologous leukocytes in man. J Nucl Med 1977;18:1014-21.
12. Weiner RE, Thakur ML. Imaging infection/inflammation. Pathophysiologic basis and radiopharmaceuticals. Q J Nucl Med 1999;43:2-8.
13. Allan RA, Sladen GE, Bassingham S, Lazarus C, Clarke SE, Fogelman I. Comparison of simultaneous 99mTc-HMPAO and 111In oxine labeled white cell scans in the assessment of inflammatory bowel disease. Eur J Nucl Med 1993;20:195-200.
14. Giaffer MH, Tindale WB, Holdsworth D. Value of technetium-99m HMPAO-labeled leucocyte scintigraphy as an initial screening test in patients suspected of having inflammatory bowel disease. Eur J Gastroenterol Hepatol 1996;8:1195-2000.
15. Mountford PJ, Kettle AG, O'Doherty MJ, Coakley AJ. Comparison of technetium-99m-HM-PAO leukocytes with indium-111-oxine leukocytes for localizing intraabdominal sepsis. J Nucl Med 1990;31:311-5.
16. Zoghbi SS, Thakur ML, Gottschalk A. Selective cell labeling: a potential radioactive agent for labeling human neutrophils. J Nucl Med 1981;22:32.
17. Rubin RH, Fischman AJ, Needleman M, Wilkinson R, Callahan RJ, Khaw BA et al. Radiolabeled, nonspecific, polyclonal human immunoglobulin in the detection of focal inflammation by scintigraphy: comparison with gallium-67 citrate and technetium-99m-labeled albumin. J Nucl Med 1989;30:385-9.
18. Van der Laken CJ, Boerman OC, Oyen WJ, van de Ven MT, Claessens RA, van der Meer JW et al. Specific targeting of infectious foci with radioiodinated human recombinant interleukin-1 in an experimental model. Eur J Nucl Med 1995;22:1249-55.
19. Abrams MJ, Juweid M, TenKate CI, Schwartz DA, Hauser MM, Gaul FE et al. Technetium-99m-human polyclonal IgG radiolabeled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats. J Nucl Med 1990;31:2022-8.
20. Oyen WJ, Claessens RA, van der Meer JW, Rubin RH, Strauss HW, Corstens FH. Indium-111-labeled human nonspecific immunoglobulin G: a new radiopharmaceutical for imaging infectious and inflammatory foci. Clin Infect Dis 1992;14:1110-8.
21. Senda M, Fishman AJ, Weise S, Alpert NM, Correia JA, Rubin RH et al. Regional perfusion, oxygen metabolism, blood volume and immunoglobulin G accumulation at focal sites of infection in rabbits. Eur J Nucl Med 1992;19:166-72.
22. Thakur ML, DeFulvio J, Park CH, Damjanov A, Yaghsezian H, Jungkind D et al. Technetium-99m labeled proteins for imaging inflammatory foci. Int J Rad Appl Instrum B 1991;18:605-12.
23. Juweid M, Strauss HW, Yaoita H, Rubin RH, Fischman AJ. Accumulation of immunoglobulin G at focal sites of inflammation. Eur J Nucl Med 1992;19:159-65.
24. Nijhof MW, Oyen WJ, Van Kampen VA, Claessens RA, van der Meer JW, Corstens FH. Evaluation of infections of the locomotor system with indium-111-labeled human IgG scintigraphy. J Nucl Med 1997;38:1300-5.
25. Jiang MS, Corley EG, Wagner HN Jr, Tsan MF. Localization of abscess with an iodinated synthetic chemotactic peptide. Nuklearmedizin 1982;21:110-3.
26. Babich JW, Graham W, Barrow SA, Dragotakes SC, Tompkins RG, Rubin RH et al. Technetium-99m-labeled chemotactic peptides: comparison with indium-111-labeled white blood cells for localizing acute bacterial infection in the rabbit. J Nucl Med 1993;34:2176-81.
27. Babich JW, Solomon H, Pike MC, Kroon D, Graham W, Abrams MJ et al. Technetium-99m-labeled hydrazino nicotinamide derivatized chemotactic peptide analogs for imaging focal sites of bacterial infection. J Nucl Med 1993;34:1964-74.
28. Babich JW, Graham W, Barrow SA, Fischman AJ. Comparison of the infection imaging properties of a 99mTc labeled chemotactic peptide with 111In IgG. Nucl Med Biol 1995;22:643-8.
29. Moyer BR, Vallabhajosula S, James LJ, Bush LR, Cyr JE, Snow DA et al. Technetium-99m-white blood cell-specific imaging agent developed from platelet factor 4 to detect infection. J Nucl Med 1996;37:673-9.
30. Schiffmann E, Corcoran BA, Wahl SM. N-formylmethionyl peptides as chemoattractants for leucocytes. Proc Natl Acad Sci U S A 1975;72:1059-62.
31. Showell HJ, Freer RJ, Zigmond SH, Schiffmann E, Aswanikumar S, Corcoran B et al. The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils. J Exp Med 1976;143:1154-69.
32. Rao PS, Pallela VR, Vassileva-Belnikolovska D, Jungkind D, Thakur ML. A receptor-specific peptide for imaging infection and inflammation. Nucl Med Commun 2000;21:1063-70.
33. Kunkel SL, Lukacs N, Strieter RM. Chemokines and their role in human disease. Agents Actions Suppl 1995;46:11-22.
34. Stocks SC, Albrechtsen M, Kerr MA. Expression of the CD15 differentiation antigen (3-fucosyl-Nacetyl-lactosamine, Lex) on putative neutrophil adhesion molecules. CR3 and NCA-160. Biochem J 1990;268, 275-80.
35. Weiner RE, Thakur ML. Imaging infection/inflammation. Pathophysiologic basis and radiopharmaceuticals. Q J Nucl Med 1999;43:2-7.
36. Thakur ML, Richard MD, White FW. Monoclonal antibodies as agents for selective radiolabeling of human neutrophils. J Nucl Med 1988;29:1817-25.
37. Becker W, Borst U, Fischbach W, Pasurka B, Schafer R, Borner W. Kinetic data of in-vivo labeled granulocytes in humans with a murine Tc-99m-labelled monoclonal antibody. Eur J Nucl Med 1989;15:361-6.
38. Becker W, Bair J, Behr T, Repp R, Streckenbach H, Beck H et al. Detection of soft-tissue infections and osteomyelitis using a technetium-99m-labeled anti-granulocyte monoclonal antibody fragment. J Nucl Med 1994;35:1436-43.
39. Becker W, Palestro CJ, Winship J, Feld T, Pinsky CM, Wolf F et al. Rapid imaging of infections with a monoclonal antibody fragment (LeukoScan). Clin Orthop Relat Res 1996;329:263-72.
40. Mozley PD, Thakur ML, Alavi A, Smith T, Barraclough ED, Wilding P et al. Effects of a 99mTc-labeled murine immunoglobulin M antibody to CD15 antigens on human granulocyte membranes in healthy volunteers. J Nucl Med 1999;40:2107-14.
41. NeutroSpec (Technetium [99mTc] Fanolesomab): reports of fatal and life threatening cardiopulmonary event. Source: MedWatch, posted 05 December 2005 in snm.org, nuclear medicine news.
42. Harris JF, Chin J, Jewett MA, Kennedy M, Gorczynski RM. Monoclonal antibodies against SSEA-1 antigen: binding properties and inhibition of human natural killer cell activity against target cells bearing SSEA-1 antigen. J Immunol 1984;132:2502-9.
43. Skubitz KM, Snook RW 2nd. Monoclonal antibodies that recognize lacto-N-fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA-1/HMac-1/gp 150,95) and CR1 on human neutrophils. J Immunol 1987;139:1631-9.
44. Gratz S, Behr T, Herrmann A, Dresing K, Tarditi L, Franceschini R et al. Intraindividual comparison of 99mTc-labelled anti-SSEA-1 antigranulocyte antibody and 99mTc-HMPAO labelled white blood cells for the imaging of infection. Eur J Nucl Med 1998;25:386-93.
45. Thakur ML, Defulvio JD. Technetium-99m-labeled monoclonal antibodies for immunoscintigraphy. Simplified preparation and evaluation. J Immunol Methods 1991;137:217-24.
46. Meares CF, McCall MJ, Reardan DT, Goodwin DA, Diamanti CI, McTigue M. Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions. Anal Biochem 1984;142:68-78.
47. Rodwell JD, Alvarez VL, Lee C, Lopes AD, Goers JW, King HD et al. Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations. Proc Natl Acad Sci U S A 1986;83:2632-6.
48. Thakur ML, Thiagarajan P, White F 3rd, Park CH, Maurer PH. Monoclonal antibodies for specific cell labeling: considerations, preparations and preliminary evaluation. Int J Rad Appl Instrum B 1987;14:51-8.
49. Paik CH, Eckelman WC, Reba RC. Related Articles, Links Transchelation of 99mTc from low affinity sites to high affinity sites of antibody. Int J Rad Appl Instrum B 1986;13:359-62.
50. Thakur ML, White 3d F, Tricheri G. Specific radiolabeling of human neutrophils: evaluation of 111 Indium labeled antibodies B.37.2.1. J Nucl Med 1896;27:947.
51. Solter D, Knowles BB Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci U S A 1978;75:5565-9.
52. Thakur ML, Lee J, Defulvio J, Richard MD, Park CH. Human neutrophils: evaluation of adherence, chemotaxis and phagocytosis, following interaction with radiolabeled antibodies. Nucl Med Common 1990;11:37-43.
53. Thakur ML. Live bacteria labeled with Indium-111. Eur J Nucl Med 1986;13:266.
54. Mozley DP, Stubbs JB, Dresel SH, Barraclough ED, Smith T, Patel M et al. Radiation dosimetry of a 99mTc-labeled IgM murine antibody to CD15 antigens on human granulocytes. J Nucl Med 1999;40:625-30.
55. Van Kroonenburgh MJ, Pauwels EK. Human immunological response to mouse monoclonal antibodies in the treatment or diagnosis of malignant diseases. Nucl Med Commun 1988;9: 919-30.
56. Georgitis JW, Browning MC, Steiner D, Lorentz WB. Anaphylaxis and desensitization to the murine monoclonal antibody used for renal graft rejection. Ann Allergy 1991;66:343-7.
57. Line BR, Breyer RJ, McElvany KD, Earle DC, Khazaeli MB. Evaluation of human anti-mouse antibody response in normal volunteers following repeated injections of fanolesomab (NeutroSpec), a murine anti-CD15 IgM monoclonal antibody for imaging infection. Nucl Med Commun 2004;25:807-11.
58. Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990;132:910-25.
59. Rypins EB, Evans DG, Hinrichs W, Kipper SL. Tc-99m-hmpao white blood cell scan for diagnosis of acute appendicitis in patients with equivocal clinical presentation. Ann Surg 1997;226:58-65.
60. Kipper SL, Rypins EB, Evans DG, Thakur ML, Smith TD, Rhodes B. Neutrophil-specific 99mTc-labeled anti-CD15 monoclonal antibody imaging for diagnosis of equivocal appendicitis. J Nucl Med 2000;41:449-55.
61. Palestro CJ, Kipper SL, Weiland FL, Love C, Tomas MB. Osteomyelitis: diagnosis with 99mTc-labeled antigranulocyte antibodies compared with diagnosis with 111In-labeled leukocytes: initial experience. Radiology 2002;223:758-64.