Promoter characterization and transcriptional regulation of Ncb5or, a novel reductase necessary for pancreatic β-cell maintenance

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1759, Issue 5, 2006, Pages 257-262

  Larade, Kevin ^a   Bunn, H Franklin ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Beta cell; Diabetes; Ncb5or; Promoter; Reductase

Indexed keywords

ARTICLE; BINDING KINETICS; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME LOCALIZATION; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCATION; HUMAN; HUMAN CELL; NCB5OR GENE; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; BASE SEQUENCE; CELL SURVIVAL; CONSENSUS SEQUENCE; CYTOCHROME-B(5) REDUCTASE; GENE EXPRESSION REGULATION; INSULIN-SECRETING CELLS; KIDNEY; MICE; MOLECULAR SEQUENCE DATA; MYOCARDIUM; PANCREAS; PROMOTER REGIONS (GENETICS); SEQUENCE DELETION; TISSUE DISTRIBUTION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

EID: 33745905055     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2006.05.002     Document Type: Article

References (15)

1. Concannon P., Gogolin-Ewens K.J., Hinds D.A., Wapelhorst B., Morrison V.A., Stirling B., Mitra M., Farmer J., Williams S.R., Cox N.J., Bell G.I., Risch N., and Spielman R.S. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat. Genet. 19 (1998) 292-296
2. Kadowaki T. Insights into insulin resistance and type 2 diabetes from knockout mouse models. J. Clin. Invest. 106 (2000) 459-465
3. Fajans S.S., Bell G.I., and Polonsky K.S. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N. Engl. J. Med. 345 (2001) 971-980
4. Kahn C.R., Vicent D., and Doria A. Genetics of non-insulin-dependent (type-II) diabetes mellitus. Annu. Rev. Med. 47 (1996) 509-531
5. Xie J., Zhu H., Larade K., Ladoux A., Seguritan A., Chu M., Ito S., Bronson R.T., Leiter E.H., Zhang C.Y., Rosen E.D., and Bunn H.F. Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 10750-10755
6. Zhu H., Larade K., Jackson T.A., Xie J., Ladoux A., Acker H., Berchner-Pfannschmidt U., Fandrey J., Cross A.R., Lukat-Rodgers G.S., Rodgers K.R., and Bunn H.F. NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J. Biol. Chem. 279 (2004) 30316-30325
7. Zhu H., Qiu H., Yoon H.W., Huang S., and Bunn H.F. Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 14742-14747
8. Frazer K.A., Pachter L., Poliakov A., Rubin E.M., and Dubchak I. VISTA: computational tools for comparative genomics. Nucleic Acids Res. 32 (2004) W273-W279
9. Kataoka K., Shioda S., Ando K., Sakagami K., Handa H., and Yasuda K. Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells. J. Mol. Endocrinol. 32 (2004) 9-20
10. Pauza M.E., Nguyen A., Wolfe T., Ho I.C., Glimcher L.H., von Herrath M., and Lo D. Variable effects of transgenic c-Maf on autoimmune diabetes. Diabetes 50 (2001) 39-46
11. Atouf F., Czernichow P., and Scharfmann R. Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer. J. Biol. Chem. 272 (1997) 1929-1934
12. Kemp D.M., Lin J.C., and Habener J.F. Regulation of Pax4 paired homeodomain gene by neuron-restrictive silencer factor. J. Biol. Chem. 278 (2003) 35057-35062
13. Martin D., Tawadros T., Meylan L., Abderrahmani A., Condorelli D.F., Waeber G., and Haefliger J.A. Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines. J. Biol. Chem. 278 (2003) 53082-53089
14. Fry C.J., and Farnham P.J. Context-dependent transcriptional regulation. J. Biol. Chem. 274 (1999) 29583-29586
15. Toyoda A., Fukumaki Y., Hattori M., and Sakaki Y. Mode of activation of the GC box/Sp1-dependent promoter of the human NADH-cytochrome b5 reductase-encoding gene. Gene 164 (1995) 351-355