Pharmacological and toxicological testing of the enantiomers of two chiral fomocaine alkylmorpholine derivatives in comparison to their in vitro interactions on drug metabolism in rats

Arzneimittel-Forschung/Drug Research

Volumn 56, Issue 6, 2006, Pages 369-376

  Lupp, Amelie ^a,b   Wange, Johannes ^a   Oelschläger, Herbert ^a   Fleck, Christian ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Alkylmorpholine; Cytochrome P450; Fomocaine, alkylmorpholine derivatives, enantiomers; Local anaesthetics, toxicity

Indexed keywords

CYTOCHROME P450; FOMOCAINE; MORPHOLINE DERIVATIVE; OW13; OW3; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ARTICLE; CHIRALITY; CONCENTRATION RESPONSE; DRUG METABOLISM; ENANTIOMER; LD 50; MICROSOME; NONHUMAN; PARESIS; RAT; TOXICITY;

EID: 33745886509     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296736     Document Type: Article

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