18F FDG-PET imaging in musculoskeletal infection

Quarterly Journal of Nuclear Medicine and Molecular Imaging

Volumn 50, Issue 2, 2006, Pages 131-142

  Stumpe, Katrin D M ^a,b   Strobel, K ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Arthroplasty; Computed tomography; Fluorodeoxyglucose F18; Infection; Musculoskeletal diseases; Osteomyelitis; Positron emission tomography

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GALLIUM 67; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; INDIUM 111; TECHNETIUM SULFUR COLLOID TC 99M; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ARTIFACT; BONE INFECTION; BONE SCINTISCANNING; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DIABETIC FOOT; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISKITIS; DRUG ACCUMULATION; DRUG COST; DRUG UPTAKE; EARLY DIAGNOSIS; ENDOPROSTHESIS LOOSENING; FALSE POSITIVE RESULT; HISTOPATHOLOGY; HUMAN; IMAGE QUALITY; INTERMETHOD COMPARISON; JOINT PROSTHESIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOMYELITIS; POSITRON EMISSION TOMOGRAPHY; PROSTHESIS INFECTION; REVIEW; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOFT TISSUE INFECTION; TREATMENT INDICATION; IMAGE ENHANCEMENT; METABOLISM; METHODOLOGY; MYOSITIS; OSTEITIS; SCINTISCANNING;

CLINICAL TRIALS; FLUORODEOXYGLUCOSE F18; HUMANS; IMAGE ENHANCEMENT; MYOSITIS; OSTEITIS; OSTEOMYELITIS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 33745881891     PISSN: 18244785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (79)

1. Chung JK, Yeo J, Lee DS, Park S, Lee MC, Kim BK et al. Bone marrow scintigraphy using technetium-99m-antigranulocyte antibody in hematologic disorders. J Nucl Med 1996;37:978-82.
2. Jacobson AF, Gilles CP, Cerqueira MD. Photopenic defects in marrow-containing skeleton on indium-111 leucocyte scintigraphy: prevalence at sites suspected of osteomyelitis and as an incidental finding. Eur J Nucl Med 1992;19:858-64.
3. Gratz S, Braun HG, Behr TM, Meller J, Herrmann A, Conrad M et al. Photopenia in chronic vertebral osteomyelitis with technetium-99m-antigranulocyte antibody (BW 250/183). J Nucl Med 1997;38: 211-6.
4. Bleeker-Rovers CP, de Kleijn EM, Corstens FH, van der Meer JW, Oyen WJ. Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation. Eur J Nucl Med Mol Imaging 2004;31:29-37.
5. Termaat MF, Raijmakers PG, Scholten HJ, Bakker FC, Patka P, Haarman HJ. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. J Bone Joint Surg Am 2005;87:2464-71.
6. Ichiya Y, Kuwabara Y, Sasaki M, Yoshida T, Akashi Y, Murayama S et al. FDG-PET in infectious lesions: The detection and assessment of lesion activity. Ann Nucl Med 1996;10:185-91.
7. Sugawara Y, Braun DK, Kison PV, Russo JE, Zasadny KR, Wahl RL. Rapid detection of human infections with fluorine-18 fluorodeoxyglucose and positron emission tomography: preliminary results. Eur J Nucl Med 1998;25:1238-43.
8. Guhlmann A, Brecht-Krauss D, Suger G, Glatting G, Kotzerke J, Kinzl L et al. Chronic osteomyelitis: detection with FDG PET and correlation with histopathologic findings. Radiology 1998;206:749-54.
9. Guhlmann A, Brecht-Krauss D, Suger G, Glatting G, Kotzerke J, Kinzl L et al. Fluorine-18-FDG PET and technetium-99m antigranulocyte antibody scintigraphy in chronic osteomyelitis. J Nucl Med 1998;39:2145-52.
10. Kalicke T, Schmitz A, Risse JH, Arens S, Keller E, Hansis M et al. Fluorine-18 fluorodeoxyglucose PET in infectious bone diseases: results of histologically confirmed cases. Eur J Nucl Med 2000;27: 524-8.
11. Stumpe KD, Dazzi H, Schaffner A, von Schulthess GK. Infection imaging using whole-body FDG-PET. Eur J Nucl Med 2000;27:822-32.
12. Zhuang H, Duarte PS, Pourdehand M, Shnier D, Alavi A. Exclusion of chronic osteomyelitis with F-18 fluorodeoxyglucose positron emission tomographic imaging. Clin Nucl Med 2000;25:281-4.
13. de Winter F, van de Wiele C, Vogelaers D, de Smet K, Verdonk R, Dierckx RA. Fluorine-18 fluorodeoxyglucose-position emission tomography: a highly accurate imaging modality for the diagnosis of chronic musculoskeletal infections. J Bone Joint Surg Am 2001;83-A:651-60.
14. Schiesser M, Stumpe KD, Trentz O, Kossmann T, Von Schulthess GK. Detection of metallic implant-associated infections with FDG PET in patients with trauma: correlation with microbiologic results. Radiology 2003;226:391-8.
15. Beckers C, Ribbens C, Andre B, Marcelis S, Kaye O, Mathy L et al. Assessment of disease activity in rheumatoid arthritis with (18)F-FDG PET. J Nucl Med 2004;45:956-64.
16. Beckers C, Jeukens X, Ribbens C, Andre B, Marcelis S, Leclercq P et al. (18)F-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3. Eur J Nucl Med Mol Imaging 2005 [Epub ahead of print].
17. von Schulthess GK, Meier N, Stumpe KD. Joint accumulations of FDG in whole body PET scans. Nuklearmedizin 2001;40:193-7.
18. Meyer M, Gast T, Raja S, Hubner K. Increased F-18 FDG accumulation in an acute fracture. Clin Nucl Med 1994;19:13-4.
19. Zhuang H, Sam JW, Chacko TK, Duarte PS, Hickeson M, Feng Q et al. Rapid normalization of osseous FDG uptake following traumatic or surgical fractures. Eur J Nucl Med Mol Imaging 2003;30: 1096-103.
20. Wandler E, Kramer EL, Sherman O, Babb J, Scarola J, Rafii M. Diffuse FDG shoulder uptake on PET is associated with clinical findings of osteoarthritis. AJR Am J Roentgenol 2005;185:797-803.
21. Love C, Tomas MB, Marwin SE, Pugliese PV, Palestro CJ. Role of nuclear medicine in diagnosis of the infected joint replacement. Radiographics 2001;21:1229-38.
22. 99mTc-sulfur colloid marrow imaging. J Nucl Med 2004;45:1864-71.
23. Stumpe KD, Notzli HP, Zanetti M, Kamel EM, Hany TF, Gorres GW et al. FDG PET for differentiation of infection and aseptic loosening in total hip replacements: comparison with conventional radiography and three-phase bone scintigraphy. Radiology 2004;231:333-41.
24. 18F-FDG uptake in experimental soft-tissue abscesses in rats. Radiology 2002;223:446-51.
25. Babior BM. The respiratory burst of phagocytes. J Clin Invest 1984;73:599-601.
26. Ma LD, Frassica FJ, Bluemke DA, Fishman EK. CT and MRI evaluation of musculoskeletal infection. Crit Rev Diagn Imaging 1997;38:535-68.
27. Kaim A, Ledermann HP, Bongartz G, Messmer P, Muller-Brand J, Steinbrich W. Chronic post-traumatic osteomyelitis of the lower extremity: comparison of magnetic resonance imaging and combined bone scintigraphy/ immunoscintigraphy with radiolabelled monoclonal antigranulocyte antibodies. Skeletal Radiol 2000;29:378-86.
28. Chung T. Magnetic resonance imaging in acute osteomyelitis in children. Pediatr Infect Dis J 2002;21:869-70.
29. Santiago Restrepo C, Gimenez CR, McCarthy K. Imaging of osteomyelitis and musculoskeletal soft tissue infections: current concepts. Rheum Dis Clin North Am 2003;29:89-109.
30. Wing VW, Jeffrey RB Jr, Federle MP, Helms CA, Trafton P. Chronic osteomyelitis examined by CT. Radiology 1985;154:171-4.
31. 67Ga imaging following insertion of orthopedic devices. Radiology 1979;133:717-21.
32. Schauwecker DS, Park HM, Mock BH, Burt RW, Kernick CB, Ruoff AC 3rd et al. Evaluation of complicating osteomyelitis with Tc-99m MDP, In-111 granulocytes, and Ga-67 citrate. J Nucl Med 1984;25:849-53.
33. Schauwecker DS. The scintigraphic diagnosis of osteomyelitis. AJR Am J Roentgenol 1992;158:9-18.
34. Palestro CJ, Torres MA. Radionuclide imaging in orthopedic infections. Semin Nucl Med 1997;27:334-45.
35. Kolindou A, Liu Y, Ozker K, Krasnow AZ, Isitman AT, Hellman RS et al. In-111 WBC imaging of osteomyelitis in patients with underlying bone scan abnormalities. Clin Nucl Med 1996;21:183-91.
36. Seabold JE, Nepola JV, Conrad GR, Marsh JL, Montgomery WJ, Bricker JA et al. Detection of osteomyelitis at fracture nonunion sites: comparison of two scintigraphic methods. AJR Am J Roentgenol 1989;152:1021-7.
37. 111In leukocyte scintigraphy. AJR Am J Roentgenol 1987;148:927-30.
38. Datz FL. Indium-111-labeled leukocytes for the detection of infection: current status. Semin Nucl Med 1994;24:92-109.
39. Palestro CJ, Kim CK, Swyer AJ, Vallabhajosula S, Goldsmith SJ. Radionuclide diagnosis of vertebral osteomyelitis: indium-111-leukocyte and technetium-99m-methylene diphosphonate bone scintigraphy. J Nucl Med 1991;32:1861-5.
40. Fayad LM, Cohade C, Wahl RL, Fishman EK. Sacral fractures: a potential pitfall of FDG positron emission tomography. AJR Am J Roentgenol 2003;181:1239-43.
41. Fayad LM, Kawamoto S, Kamel IR, Bluemke DA, Eng J, Frassica FJ et al. Distinction of long bone stress fractures from pathologic fractures on cross-sectional imaging: how successful are we? AJR Am J Roentgenol 2005;185:915-24.
42. Kaim AH, Gross T, von Schulthess GK. Imaging of chronic posttraumatic osteomyelitis. Eur Radiol 2002;12:1193-202.
43. Henry G, Garner WL. Inflammatory mediators in wound healing. Surg Clin North Am 2003;83:483-507.
44. 18F-FDG PET: review of the current literature. J Nucl Med Technol 2004;32:12-5.
45. 18F]-fluorodeoxyglucose uptake in abdominal abscesses: a PET study. J Comput Assist Tomogr 1989;13:829-31.
46. Newman LG, Waller J, Palestro CJ, Schwartz M, Klein MJ, Hermann G et al. Unsuspected osteomyelitis in diabetic foot ulcers. Diagnosis and monitoring by leukocyte scanning with indium in 111 oxyquinoline. JAMA 1991;266:1246-51.
47. Chatha DS, Cunningham PM, Schweitzer ME. MR imaging of the diabetic foot: diagnostic challenges. Radiol Clin North Am 2005;43:747-759, ix.
48. Ahmadi ME, Morrison WB, Carrino JA, Schweitzer ME, Raikin SM, Ledermann HP. Neuropathic arthropathy of the foot with and without superimposed osteomyelitis: MR imaging characteristics. Radiology 2006;238:622-31.
49. Palestro CJ, Tomas MB. Scintigraphic evaluation of the diabetic foot.: In: Freeman LM, editor. Nuclear Medicine Annual: Lippincott Williams & Williams; 2000.p.143-72.
50. Hopfner S, Krolak C, Kessler S, Tiling R, Brinkbaumer K, Hahn K et al. Preoperative imaging of Charcot neuroarthropathy in diabetic patients: comparison of ring PET, hybrid PET, and magnetic resonance imaging. Foot Ankle Int 2004;25:890-5.
51. 18F-FDG PET/CT. J Nucl Med 2005; 46:444-9.
52. Ledermann HP, Schweitzer ME, Morrison WB, Carrino JA. MR imaging findings in spinal infections: rules or myths? Radiology 2003;228:506-14.
53. Modic MT, Feiglin DH, Piraino DW, Boumphrey F, Weinstein MA, Duchesneau PM et al. Vertebral osteomyelitis: assessment using MR. Radiology 1985;157:157-66.
54. Love C, Patel M, Lonner BS, Tomas MB, Palestro CJ. Diagnosing spinal osteomyelitis: a comparison of bone and Ga-67 scintigraphy and magnetic resonance imaging. Clin Nucl Med 2000;25:963-77.
55. Stumpe KD, Zanetti M, Weishaupt D, Hodler J, Boos N, Von Schulthess GK. FDG positron emission tomography for differentiation of degenerative and infectious endplate abnormalities in the lumbar spine detected on MR imaging. AJR Am J Roentgenol 2002;179:1151-7.
56. Schmitz A, Risse JH, Grunwald F, Gassel F, Biersack HJ, Schmitt O. Fluorine-18 fluorodeoxyglucose positron emission tomography findings in spondylodiscitis: preliminary results. Eur Spine J 2001;10:534-9.
57. 18F-FDG hybrid PET in patients with suspected spondylitis. Eur J Nucl Med Mol Imaging 2002;29:516-24.
58. McKay ND, Robinson B, Brodie R, Rooke-Allen N. Glucose transport and metabolism in cultured human skin fibroblasts. Biochim Biophys Acta 1983;762:198-204.
59. Gold RH, Hawkins RA, Katz RD. Bacterial osteomyelitis: findings on plain radiography, CT, MR, and scintigraphy. AJR Am J Roentgenol 1991;157:365-70.
60. Suh JS, Jeong EK, Shin KH, Cho JH, Na JB, Kim DH et al. Minimizing artifacts caused by metallic implants at MR imaging: experimental and clinical studies. AJR Am J Roentgenol 1998;171: 1207-13.
61. White LM, Kim JK, Mehta M, Merchant N, Schweitzer ME, Morrison WB et al. Complications of total hip arthroplasty: MR imaging-initial experience. Radiology 2000;215:254-62.
62. White LM, Buckwalter KA. Technical considerations: CT and MR imaging in the postoperative orthopedic patieni. Semin Musculoskelet Radiol 2002;6:5-17.
63. Palestro CJ, Roumanas P, Swyer AJ, Kim CK, Goldsmith SJ. Diagnosis of musculoskeletal infection using combined In-111 labeled leukocyte and Tc-99m SC marrow imaging. Clin Nucl Med 1992;17:269-73.
64. Robiller FC, Stumpe KD, Kossmann T, Weisshaupt D, Bruder E, von Schulthess GK. Chronic osteomyelitis of the femur: value of PET imaging. Eur Radiol 2000;10:855-8.
65. Unger E, Moldofsky P, Gatenby R, Hartz W, Broder G. Diagnosis of osteomyelitis by MR imaging. AJR Am J Roentgenol 1988;150: 605-10.
66. Hanssen AD, Rand JA. Evaluation and treatment of infection at the site of a total hip or knee arthroplasty. Instr Course Lect 1999;48: 111-22.
67. Andrews HJ, Arden GP, Hart GM, Owen JW. Deep infection after total hip replacement. J Bone Joint Surg Br 1981;63-B:53-7.
68. Maderazo EG, Judson S, Pasternak H. Late infections of total joint prostheses. A review and recommendations for prevention. Clin Orthop Relat Res 1988;:131-42.
69. Fitzgerald RH, Jr. Problems associated with the infected total hip arthroplasty. Clin Rheum Dis 1986;12:537-54.
70. Cuckler JM, Star AM, Alavi A, Noto RB. Diagnosis and management of the infected total joint arthroplasty. Orthop Chin North Am 1991;22:523-30.
71. Gomez-Luzuriaga MA, Galan V, Villar JM. Scintigraphy with Tc, Ga and In in painful total hip prostheses. Int Orthop 1988;12:163-7.
72. Merkel KD, Brown ML, Fitzgerald RH Jr. Sequential technetium-99m HMDP-gallium-67 citrate imaging for the evaluation of infection in the painful prosthesis. J Nucl Med 1986;27:1413-7.
73. Zhuang H, Duarte PS, Pourdehnad M, Maes A, Van Acker F, Shnier D et al. The promising role of 18F-FDG PET in detecting infected lower limb prosthesis implants. J Nucl Med 2001;42:44-8.
74. Chacko TK, Zhuang H, Nakhoda KZ, Moussavian B, Alavi A. Applications of fluorodeoxyglucose positron emission tomography in the diagnosis of infection. Nucl Med Commun 2003;24:615-24.
75. Manthey N, Reinhard P, Moog F, Knesewitsch P, Hahn K, Tatsch K. The use of [18 F]fluorodeoxyglucose positron emission tomography to differentiate between synovitis, loosening and infection of hip and knee prostheses. Nucl Med Commun 2002;23:645-53.
76. Reinartz P, Mumme T, Hermanns B, Cremerius U, Wirtz DC, Schaefer WM et al. Radionuclide imaging of the painful hip arthroplasty: positron-emission tomography versus triple-phase bone scanning. J Bone Joint Surg Br 2005;87:465-70.
77. 99mTc-HMPAO white blood cell SPET and bone scintigraphy in the evaluation of painful total knee arthroplasties. Eur J Nucl Med 2001;28:1496-504.
78. Goerres GW, Ziegler SI, Burger C, Berthold T, Von Schulthess GK, Buck A. Artifacts at PET and PET/CT caused by metallic hip prosthetic material. Radiology 2003;226:577-84.
79. Heiba SI, Luo J, Sadek S, Macalental E, Cacavio A, Rosen G et al. Attenuation-correction induced artifact in F-18 FDG PET imaging following total knee replacement. Clin Positron Imaging 2000;3:237-9.