COX-2 expression in canine and feline invasive mammary carcinomas: Correlation with clinicopathological features and prognostic fmolecular markers

Breast Cancer Research and Treatment

Volumn 98, Issue 1, 2006, Pages 115-120

  Millanta, F ^a   Citi, S ^a   Della Santa, D ^a   Porciani, M ^a   Poli, A ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Angiogenesis; Cat; COX 2; Dog; HER 2; Mammary tumors; Prognosis

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; KI 67 ANTIGEN; PROGESTERONE RECEPTOR; VASCULOTROPIN;

AGE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GRADING; CANCER INVASION; CARCINOGENESIS; CAT; CONTROLLED STUDY; DOG; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INVASIVE CARCINOMA; MAMMARY GLAND; MICROVASCULATURE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SPECIES DIFFERENCE; TISSUE SECTION; TUMOR CELL; TUMOR DIFFERENTIATION; TUMOR VASCULARIZATION; TUMOR VOLUME;

ANIMALS; CATS; CYCLOOXYGENASE 2; DOGS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOHISTOCHEMISTRY; MAMMARY NEOPLASMS, ANIMAL; MODELS, STATISTICAL; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 33745880112     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-005-9138-z     Document Type: Article

References (37)

1. Singh-ranger G, Mokbel K: The role of cyclooxygenase-2 (COX-2 in breast cancer, and implication of COX-2 inhibition. Eur J Surg Oncol 28: 729-737, 2002
2. Appleby SB, Ristimaki A, Neilson K, Narko K, Hla T: Structure of the human cyclooxygenase-2 gene. Biochem J 302: 723-727, 1994
3. Williams CS, Mann M, DuBois RN: The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 18: 7908-7916, 1999
4. Thun MJ, Henley SJ, Parono C: Non-steroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 91: 1398-1403, 1999
5. Khan KNM, Knapp DW, Denicola DB, Harris RK: Expression of cyclooxygenase-2 in transitional cell carcinoma of the urinary bladder in dogs. Am J Vet Res 61: 478-481, 2000
6. Khan KNM, Stanfield KM, Trajkovic D, Knapp DW: Expression of cyclooxygenase-2 in canine renal cell carcinoma. Vet Pathol 38: 116-119, 2001
7. McEntee MF, Cates JM, Neilsen N: Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs. Vet Pathol 39: 428-436, 2002
8. Beam SL, Rassnick KM, Moore AS, McDonough SP: An immunohistochemical study of Cyclooxygenase-2 expression in various feline neoplasms. Vet Pathol 40: 496-500, 2003
9. Mohammed SI, Khan KNM, Sellers RS, Hayek MG, De Nicola DB, Wu L, Bonney PL, Knapp DW: Expression of cyclooxygenase-1 and 2 in naturally-occurring canine cancer. Prostag Leukotr Ess 70: 479-483, 2004
10. Mann M, Sheng H, Shao J, William CS, Pisacane PI, Sliwkowski MX, DuBois RN: Targeting cyclooxygenase-2 and HER-2/neu pathways inhibits colorectal carcinoma growth. Gastronterology 120: 1713-1719, 2001
11. Kirkpatrick K, Ogunkolade W, Elkak A, et al.: The mRNA expression of cyclo-oxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in human breast cancer. Curr Med Res Opin 18: 237-241, 2002
12. Tsujii M, Kawano S, Tsujii S, Sawaoka H, Hori M, Dubois RN: Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 18: 237-241, 1998
13. Millanta F, Lazzeri G, Vannozzi I, Viacava P, Poli A: Correlation of Vascular Endothelial Growth Factor Expression to overall survival in feline invasive mammary carcinomas. Vet Pathol 39(6): 690-696, 2002b
14. Restucci B, Papparella S, Maiolino P, De Vico G: Expression of Vascular Endothelial Growth Factor in canine mammary tumours. Vet Pathol 39: 488-493, 2002
15. Mehta RG, Moon RC: Characterization of effective chemopreventive agents in mammary gland in vitso using an initiation-promotion protocol. Anticancer Res 11: 593-596, 1991
16. Chang SH, Liu CH, Conway R, Han DK, Nithipatilom K, Trifan OC, Lane TF, Hla T: Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci 101(2): 591-596, 2004
17. Misdorp W, Else RW, Hellmen E, Lipscomb TP: Histological Classification of Mammary Tumours of the Dog and the Cat. Second series. Vol. VII. WHO International Histological Classification of Tumors of Domestic Animals. Armed Forces Institute of Pathology, American Registry of Pathology, Washington DC, pp. 16-27, 1999
18. Elston CW, Ellis IO: Pathological prognostic factors in breast cancer. I. Value of histological grade breast cancer: experience from a large study with a long-term follow-up. Histopathology 19: 403-410, 1991
19. Millanta F, Lazzeri G, Mazzei M, Vannozzi I, Poli A: MIB-1 labelling index in feline dysplastic and neoplastic mammary lesions and its relationship with post-surgical prognosis. Vet Pathol 39(1): 120-126, 2002a
20. Millanta F, Calandrella M, Citi S, Della Santa D, Poli A: Overexpression of HER-2 in feline invasive mammary carcinomas: an immunohistochemical survey and evaluation of its prognostic potential. Vet Pathol 42: 30-34, 2005a
21. Millanta F, Calandrella M, Bari G, Niccolini M, Vannozzi I, Poli A: Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues. Res Vet Sci 79: 225-232, 2005b
22. Costa C, Soares R, Reis-Filho JS, Leitão D, Amendoeira I, Schmitt FC: Cyclo-oxygenase2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. J Clin Pathol 55: 429-4343, 2002
23. Ristimäki A, Sivula A, Lundin J, Lundin M, Salminen T, Haglund C, Joensuu H, Isola J: Prognostic significance of elevated Cyclooxygenase-2 expression in breast cancer. Cancer Res 62: 632-635, 2002
24. Davies G, Salter J, Hils M, Martin LA, Sacks N, Dowsett M: Correlation between Cyclooxygenase-2 expression and angiogenesis in human breast cancer. Clin Cancer Res 9: 2651-2656, 2003
25. Dore M, Lanthier I, Sirois J: Cycloxygenase-2 expression in canine mammary tumors. Vet Pathol 40: 207-212, 2003
26. Heller DA, Clifford CA, Goldschmidt DE, Holt FS, Shofer FS, Smith A, Sorenmo KU: Cyclooxygenase-2 expression is associated with histologic tumor type in canine mammary carcinoma. Vet Pathol 42: 776-780, 2005
27. Vadlamudi R, Mandal M, Adam L, Steinbach G, Mendelsohn J, Kumar R: Regulation of cyclooxygenase-2 pathway by HER2 receptor. Oncogene 18: 305-314, 1999
28. Perrone G, Santini D, Vincenzi B, Zagami M, La Cesa A, Bianchi A, Altomare V, Primavera A, Battista C, Vetrani A, Tonini G, Rabitti C: COX-2 expression in DCIS: correlation with VEGF, HER-2/neu, prognostic molecular markers and clinicopathological features. Histopathology 46: 561-568, 2005
29. Gately S, Li WW: Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy. Sem Oncol 31(suppl.7): 2-11, 2004
30. Fosslien E: Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. Ann Clin Lab Sci 31: 325-348, 2001
31. Zha S, Yegnasubramanian V, Nelson WG, Isaacs WB, De Marzo AM: Cyclooxygenase in cancer:progress and perspective. Cancer Lett 215: 1-20, 2004
32. Harris RE, Kasbari S, Farrar WB: Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer. Oncol Rep 6: 71-73, 1999
33. Harris RE, Alshafie GA, Abou-Issa H, Seibert K: Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase-2 inhibitor. Cancer Res 60: 2101-2103, 2000
34. Masferrer JL, Leahy KM, Koki AT, Zweifel BS, Settle SL, Woerner BM, Edwards DA, Flickinger AG, Moore RJ, Seibert K: Antiangiogenic and antitumor activities of cyclooxigenase-2 inhibitors. Cancer Res 60: 1306-1311, 2000
35. Howe LR, Subbaramaiah K, Brown AM, Dannenberg AJ: Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. Endocr Relat Cancer 8: 97-114, 2001
36. Mohammed SI, Bennett PF, Craig BA, et al.: Effects of the cyclooxygenase inhibitor, piroxicam, on tumor response,apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. Cancer Res 62: 356-358, 2002
37. Schmidt BR, Glickman NW, De Nicola DB, de Gortari AE, Knapp DW: Evaluation of piroxicam for the treatment of oral squamous cell carcinoma in dogs. J Am Vet Med Assoc 218: 1783-1786, 2001