Inhibition of mammalian target of rapamycin modulates expression of adhesion molecules in endothelial cells

Toxicology Letters

Volumn 165, Issue 3, 2006, Pages 242-249

  Wood, Steven C ^a   Bushar, Grace ^a   Tesfamariam, Belay ^b  

^a CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Cell adhesion molecules; Endothelial cells; mTOR signaling; Rapamycin

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C5B; COMPLEMENT COMPONENT C9; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; MAMMALIAN TARGET OF RAPAMYCIN; PADGEM PROTEIN; RAPAMYCIN; VIRUS LARGE T ANTIGEN; ZYMOSAN;

ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL ADHESION; COMPLEMENT ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; IMMUNOMODULATION; INFLAMMATORY INFILTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RESTENOSIS; TRANSLUMINAL CORONARY ANGIOPLASTY;

ANIMALS; AORTA; CELL ADHESION MOLECULES; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; PROTEIN KINASES; SIROLIMUS; SWINE;

MAMMALIA; SUIDAE;

EID: 33745870161     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2006.04.009     Document Type: Article

References (36)

1. Braun-Dullaeus R.C., Mann M.J., Seay U., Zhang L., von Der Leyen H.E., Morris R.E., and Dzau V.J. Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin. Arterioscler. Thromb. Vasc. Biol. 21 (2001) 1152-1158
2. Chen J., Zheng X.F., Brown E.J., and Schreiber S.L. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 4947-4951
3. Chiu M.I., Katz H., and Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 12574-12578
4. Dobrina A., Pausa M., Fischetti F., Bulla R., Vecile E., Ferrero E., Mantovani A., and Tedesco F. Cytolytically inactive terminal complement complex causes transendothelial migration of polymorphonuclear leukocytes in vitro and in vivo. Blood 99 (2002) 185-192
5. Dzau V.J., Braun-Dullaeus R.C., and Sedding D.G. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat. Med. 8 (2002) 1249-1256
6. Egashira K., Zhao Q., Kataoka C., Ohtani K., Usui M., Charo I.F., Nishida K., Inoue S., Katoh M., Ichiki T., and Takeshita A. Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeys. Circ. Res. 90 (2002) 1167-1172
7. Furukawa Y., Matsumori A., Ohashi N., Shioi T., Ono K., Harada A., Matsushima K., and Sasayama S. Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries. Circ. Res. 84 (1999) 306-314
8. Guba M., von B.P., Steinbauer M., Koehl G., Flegel S., Hornung M., Bruns C.J., Zuelke C., Farkas S., Anthuber M., Jauch K.W., and Geissler E.K. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat. Med. 8 (2002) 128-135
9. Haubitz M., and Brunkhorst R. Influence of a novel rapamycin analogon SDZ RAD on endothelial tissue factor and adhesion molecule expression. Transplant. Proc. 34 (2002) 1124-1126
10. Hayashi S., Watanabe N., Nakazawa K., Suzuki J., Tsushima K., Tamatani T., Sakamoto S., and Isobe M. Roles of P-selectin in inflammation, neointimal formation, and vascular remodeling in balloon-injured rat carotid arteries. Circulation 102 (2000) 1710-1717
11. Humar R., Kiefer F.N., Berns H., Resink T.J., and Battegay E.J. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J. 16 (2002) 771-780
12. Kilgore K.S., Flory C.M., Miller B.F., Evans V.M., and Warren J.S. The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells. Am. J. Pathol. 149 (1996) 953-961
13. Kilgore K.S., Schmid E., Shanley T.P., Flory C.M., Maheswari V., Tramontini N.L., Cohen H., Ward P.A., Friedl H.P., and Warren J.S. Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-kappa B activation. Am. J. Pathol. 150 (1997) 2019-2031
14. Kowalski J., Kosmider M., Pawlicki L., Glowacka E., Banasik M., Baj Z., Ciecwierz J., and Pasnik J. Complement activates neutrophils during PTCA procedure in patients with unstable angina pectoris. Int. J. Cardiol. 58 (1997) 229-240
15. Kraiss L.W., Ennis T.M., and Alto N.M. Flow-induced DNA synthesis requires signaling to a translational control pathway. J. Surg. Res. 97 (2001) 20-26
16. Kraiss L.W., Weyrich A.S., Alto N.M., Dixon D.A., Ennis T.M., Modur V., McIntyre T.M., Prescott S.M., and Zimmerman G.A. Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 278 (2000) H1537-H1544
17. Kumar A., Hoover J.L., Simmons C.A., Lindner V., and Shebuski R.J. Remodeling and neointimal formation in the carotid artery of normal and P-selectin-deficient mice. Circulation 96 (1997) 4333-4342
18. Luster A.D., Alon R., and von Andrian U.H. Immune cell migration in inflammation: present and future therapeutic targets. Nat. Immunol. 6 (2005) 1182-1190
19. Maeshima Y., Sudhakar A., Lively J.C., Ueki K., Kharbanda S., Kahn C.R., Sonenberg N., Hynes R.O., and Kalluri R. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science 295 (2002) 140-143
20. Marks A.R. Rapamycin: signaling in vascular smooth muscle. Transplant. Proc. 35 (2003) 231S-233S
21. Nath K.A., Kanakiriya S.K., Grande J.P., Croatt A.J., and Katusic Z.S. Increased venous proinflammatory gene expression and intimal hyperplasia in an aorto-caval fistula model in the rat. Am. J. Pathol. 162 (2003) 2079-2090
22. Nourse J., Firpo E., Flanagan W.M., Coats S., Polyak K., Lee M.H., Massague J., Crabtree G.R., and Roberts J.M. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372 (1994) 570-573
23. Oguchi S., Dimayuga P., Zhu J., Chyu K.Y., Yano J., Shah P.K., Nilsson J., and Cercek B. Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 1729-1736
24. Okamoto E., Couse T., De L.H., Vinten-Johansen J., Goodman R.B., Scott N.A., and Wilcox J.N. Perivascular inflammation after balloon angioplasty of porcine coronary arteries. Circulation 104 (2001) 2228-2235
25. Rollins S.A., Johnson K.K., Li L., Birks C., Matis L.A., and Rother R.P. Role of porcine P-selectin in complement-dependent adhesion of human leukocytes to porcine endothelial cells. Transplantation 69 (2000) 1659-1667
26. Schwartz R.S., and Henry T.D. Pathophysiology of coronary artery restenosis. Rev. Cardiovasc. Med. 5 Suppl. 3 (2002) S4-S9
27. Sehgal S.N. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant. Proc. 35 (2003) 7S-14S
28. Tedesco F., Fischetti F., Pausa M., Dobrina A., Sim R.B., and Daha M.R. Complement-endothelial cell interactions: pathophysiological implications. Mol Immunol 36 (1999) 261-268
29. Torzewski M., Torzewski J., Bowyer D.E., Waltenberger J., Fitzsimmons C., Hombach V., and Gabbert H.E. Immunohistochemical colocalization of the terminal complex of human complement and smooth muscle cell alpha-actin in early atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 17 (1997) 2448-2452
30. Tsuzuki S., Toyama-Sorimachi N., Kitamura F., Tobita Y., and Miyasaka M. FK506 (tacrolimus) inhibits extravasation of lymphoid cells by abrogating VLA-4/VCAM-1 mediated transendothelial migration. FEBS Lett. 430 (1998) 414-418
31. Wang K., Zhou Z., Zhou X., Tarakji K., Topol E.J., and Lincoff A.M. Prevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model. J. Am. Coll. Cardiol. 38 (2001) 577-582
32. Welt F.G., and Rogers C. Inflammation and restenosis in the stent era. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 1769-1776
33. Weyrich A.S., Dixon D.A., Pabla R., Elstad M.R., McIntyre T.M., Prescott S.M., and Zimmerman G.A. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 5556-5561
34. Yasukawa H., Imaizumi T., Matsuoka H., Nakashima A., and Morimatsu M. Inhibition of intimal hyperplasia after balloon injury by antibodies to intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1. Circulation 95 (1997) 1515-1522
35. Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., and Semenza G.L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60 (2000) 1541-1545
36. Zhou Z., Penn M.S., Forudi F., Zhou X., Tarakji K., Topol E.J., Lincoff A.M., and Wang K. Administration of recombinant P-selectin glycoprotein ligand Fc fusion protein suppresses inflammation and neointimal formation in Zucker diabetic rat model. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 1598-1603