IκB kinase 2 inhibition corrects defective nitrergic erectile mechanisms in diabetic mouse corpus cavernosum

Urology

Volumn 68, Issue 1, 2006, Pages 214-218

  Nangle, Matthew R ^a   Cotter, Mary A ^a   Cameron, Norman E ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AS 602868; I KAPPA B KINASE; I KAPPA B KINASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; STREPTOZOCIN; UNCLASSIFIED DRUG; ATROPINE; GUANETHIDINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CORPUS CAVERNOSUM; DIABETES MELLITUS; DISEASE DURATION; DRUG EFFECT; ELECTROSTIMULATION; ENZYME INHIBITION; ERECTILE DYSFUNCTION; MALE; MALE GENITAL SYSTEM FUNCTION; MOUSE; NERVE CONDUCTION; NITRERGIC NERVE; NONHUMAN; PENILE BLOOD VESSEL; PENIS ERECTION; PRIORITY JOURNAL; SMOOTH MUSCLE TONE; STREPTOZOCIN DIABETES; TREATMENT DURATION; VASCULAR ENDOTHELIUM; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; EXPERIMENTAL DIABETES MELLITUS; IN VITRO STUDY; MOUSE MUTANT; MUSCLE CONTRACTION; MUSCLE RELAXATION; PATHOPHYSIOLOGY; PENIS; PHYSIOLOGY; SMOOTH MUSCLE; VASCULARIZATION;

ANIMALS; ATROPINE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; GUANETHIDINE; I-KAPPA B KINASE; MALE; MICE; MICE, MUTANT STRAINS; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NF-KAPPA B; NITRIC OXIDE DONORS; NITROPRUSSIDE; PENILE ERECTION; PENIS; PHENYLEPHRINE; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 33745860437     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2006.01.065     Document Type: Article

References (30)

1. Kumar A., Takada Y., Boriek A.M., et al. Nuclear factor-κB. its role in health and disease. J Mol Med 82 (2004) 434-448
2. Yamamoto Y., and Gaynor R.B. IκB kinases. key regulators of the NF-κB pathway. Trends Biochem Sci 29 (2004) 72-79
3. Mohamed A.K., Bierhaus A., Schiekofer S., et al. The role of oxidative stress and NF-kappaB activation in late diabetic complications. Biofactors 10 (1999) 157-167
4. Cameron N.E., Eaton S.E.M., Cotter M.A., et al. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia 44 (2001) 1973-1988
5. Giuliano F., and Rampin O. Neural control of erection. Physiol Behav 83 (2004) 189-201
6. de Tejada I.S., Goldstein I., Azadzoi K.M., et al. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 320 (1989) 1025-1030
7. Azadzoi K.M., and de Tejada I.S. Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 148 (1992) 1587-1591
8. Gocmen C., Secilmis A., Kumcu E.K., et al. Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. Eur J Pharmacol 398 (2000) 93-98
9. Heitzer T., Finckh B., Albers S., et al. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients. relation to parameters of oxidative stress. Free Radic Biol Med 31 (2001) 53-61
10. Keegan A., Cotter M.A., and Cameron N.E. Effects of diabetes and treatment with the antioxidant, α-lipoic acid, on endothelial and neurogenic functions of corpus cavernosum in rats. Diabetologia 42 (1999) 343-350
11. Gibson T.M., Cotter M.A., and Cameron N.E. Effects of α-lipoic acid on impaired gastric fundus innervation in diabetic rats. Free Radic Biol Med 35 (2003) 160-168
12. Frelin C., Imbert V., Griessinger E., et al. Targeting NFκB activation via pharmacological inhibition of IKK2-induced apoptosis of human acute myeloid leukaemia cells. Blood 105 (2005) 804-811
13. Nangle M.R., Cotter M.A., and Cameron N.E. Protein kinase Cβ inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice. Eur J Pharmacol 475 (2003) 99-206
14. Thompson C.S., Mumtaz F.H., Khan M.A., et al. The effect of sildenafil on corpus cavernosum smooth muscle relaxation and cyclic GMP formation in the diabetic rabbit. Eur J Pharmacol 425 (2001) 57-64
15. Johnstone M.T., Creager B.S.N., Scales K.M., et al. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 88 (1993) 2510-2516
16. McVeigh S.E., Brennan G.M., Johnston G.D., et al. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 35 (1992) 771-776
17. Nangle M.R., Cotter M.A., and Cameron N.E. Effects of the peroxynitrite decomposition catalyst, FeTMPyP, on function of corpus cavernosum from diabetic mice. Eur J Pharmacol 502 (2004) 143-148
18. Way K.J., and Reid J.J. The effects of diabetes on nitric oxide-mediated responses in rat corpus cavernosum. Eur J Pharmacol 376 (1999) 73-82
19. van Etten R.W., de Koning E.J., Honing M.L., et al. Intensive lipid lowering by statin therapy does not improve vascular reactivity in patients with type 2 diabetes. Arterioscler Thromb Vasc Biol 22 (2002) 799-804
20. Lamhamedi-Cherradi S.E., Zheng S., Hilliard B.A., et al. Transcriptional regulation of type I diabetes by NF-kappaB. J Immunol 171 (2003) 4886-4892
21. Arkan M.C., Hevener A.L., Greten F.R., et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11 (2005) 191-198
22. Monaco C., and Paleolog E. Nuclear factor κB. a potential therapeutic target in atherosclerosis and thrombosis. Cardiovasc Res 61 (2004) 671-682
23. Pieper G.M., and Riaz-ul-Haq J. Activation of nuclear factor-kappaB in cultured endothelial cells by increased glucose concentration. prevention by calphostin C. Cardiovasc Pharmacol 30 (1997) 528-532
24. Ramana K.V., Friedrich B., Srivastava S., et al. Activation of nuclear factor-kappaB by hyperglycaemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes 53 (2004) 2910-2920
25. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001) 813-820
26. Price S.A., Agthong S., Middlemas A.B., et al. Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy. interactions with aldose reductase. Diabetes 53 (2004) 1851-1856
27. Luedde T., Assmus U., Wustefeld T., et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest 115 (2005) 849-859
28. Cotter M.A., Gibson T.M., and Cameron N.E. Nuclear factor kappa B inhibition improves nerve function in diabetic rats. Diabetologia 20 suppl 2 (2003) A70
29. Cameron N.E., and Cotter M.A. Diabetes causes an early reduction in autonomic ganglion blood flow in rats. J Diabetes Complications 15 (2001) 198-202
30. Cellek S., Foxwell N.A., and Moncada S. Two phases of nitrergic neuropathy in streptozotocin-induced diabetic rats. Diabetes 52 (2003) 2353-2362