Synthesis of radiolabelled 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), a neurotoxic chloral-derived mammalian alkaloid, and its biodistribution in rats

European Journal of Pharmaceutical Sciences

Volumn 28, Issue 5, 2006, Pages 412-422

  Bringmann, Gerhard ^a   Feineis, Doris ^a   Brückner, Ralph ^a   God, Ralf ^a   Grote, Christoph ^b   Wesemann, Wolfgang ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

3 14C 1 Trichloromethyl 1,2,3,4 tetrahydro carboline triple bond, long 3 14C TaClo; Biodistribution; Chloral hydrate; Mammalian alkaloids; Neurotoxins; Parkinson's disease; Pharmacokinetics

Indexed keywords

1 TRICHLOROMETHYL 1,2,3,4 TETRAHYDRO BETA CARBOLINE; ALKALOID; CARBON 14; NEUROTOXIN; UNCLASSIFIED DRUG;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); HEPATOBILIARY SYSTEM; ISOTOPE LABELING; LARGE INTESTINE; MALE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; RADIOACTIVITY; RAT; RELATIVE DENSITY; TISSUE DISTRIBUTION; URINARY EXCRETION;

ANIMALS; CARBOLINES; CARBON RADIOISOTOPES; MALE; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 33745847131     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.03.009     Document Type: Article

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