The halogenated tetrahydro-β-carboline 'TaClo': A progressively-acting neurotoxin

Journal of Neural Transmission, Supplement

Volumn , Issue 50, 1997, Pages 107-111

  Heim, Christine ^a   Sontag, K H ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; APOMORPHINE; TRYPTALINE DERIVATIVE; TRYPTOLINE; UNCLASSIFIED DRUG; CARBOLINE DERIVATIVE; NEUROTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; LOCOMOTION; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; ACCLIMATIZATION; ANIMAL; CHEMICALLY INDUCED DISORDER; CIRCADIAN RHYTHM; DRUG EFFECT; DRUG POTENTIATION; MOTOR ACTIVITY; PARKINSON DISEASE; PATHOPHYSIOLOGY; RAT; TIME;

ACCLIMATIZATION; ANIMALS; APOMORPHINE; CARBOLINES; CIRCADIAN RHYTHM; DRUG SYNERGISM; MOTOR ACTIVITY; NEUROTOXINS; PARKINSON DISEASE, SECONDARY; RATS; TIME FACTORS;

EID: 0030614653     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6842-4_11     Document Type: Article

References (11)

1. Bringmann G, God R, Feineis D, Wesemann W, Riederer P, Rausch WD, Reichmann H, Sontag KH (1995) The TaClo concept: 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) a new toxin for dopaminergic neurons. J Neural Transm [Suppl] 46: 235-244
2. Bruckner JV, Davis BD, Blancato JN (1989):Metabolism, toxicity and carcinogenicity of trichloroethylene. Crt Rev Toxicol 20: 31-50
3. Grote C, Clement HW, Wesemann W, Bringmann G, Feineis D, Riederer, P, Sontag KH (1995) Biochemical lesions of the nigrostriatal system by TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) and derivatives. J Neural Transm [Suppl] 46: 275-281
4. Janetzky B, God R, Bringmann G, Reichmann H (1995) 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline, a new inhibitor of complex I. J Neural Transm [Suppl] 46: 265-273
5. Lestienne P, Nelson J, Riederer P, Jellinger K, Reichmann H (1990) Normal mitochondrial genome in brain from patients with Parkinson's disease and complex I defect (published erratum appears in J Neurochem [1991] 56[4]: 1457). J Neurochem 55: 1810-1812
6. Mizuno Y, Ohta S, Tanaka M, Takamiya S, Suzuki K, Sato T, Oya H, Ozawa T, Kagawa Y (1989) Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun 163: 1450-1455
7. Mohanakumar KP, de Bartolomeis A, Wu RM, Yeh KJ, Sternberger LM, Peng SY, Murphy DL, Chiuh CC (1994) Ferrous-citrate complex and nigral degeneration: Evidence for free radical formation and lipid peroxidation. Ann NY Acad Sci 738: 392-399
8. O'Neill RD, Fillenz M (1985) Simultaneous monitoring of dopamine release in rat frontal cortex, nucleus accumbens and striatum: effects of drugs, circadian changes and correlations with motor activity. Neuroscience 16: 49-55
9. Rausch WD, Abdel-mohsen M, Koutsilieri E, Chan WW, Bringmann G (1995) Studies of the potentially endogenous toxin TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) in neural and glia cell cultures. J. Neural Transm [Suppl] 46: 255-263
10. Schapira AH, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden JD (1989) Mitochondrial complex I deficiency in Parkinson's disease (letter) (see comments). Lancet 1: 1269
11. Sontag KH, Heim C, Sontag TA, God R, Reichmann H, Wesemann W, Rausch WD, Riederer P, Bringmann G (1995) Long-term behavioural effects of TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) after subchronic treatment in rats. J Neural Transm [Suppl] 46: 283-289