Polymorphism of the major surface epitope of the CopB outer membrane protein of Moraxella catarrhalis

FEMS Immunology and Medical Microbiology

Volumn 47, Issue 3, 2006, Pages 343-350

  Liu, Dai Fang ^a,f   Xie, Xiaoling ^b   Mastri, Maria G ^c   Fortuna Nevin, Maria ^d   Colocillo, Christopher ^e   Fletcher, Leah ^b   Dilts, Deborah A ^a   McMichael, John C ^a   Baker, Steven M ^a  

^a Pfizer Vaccine Research Operations and Strategy   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c VACCINEX INC   (United States)

^d BAUSCH AND LOMB   (United States)

^e Nalge Nunc International   (United States)

^f PFIZER INC   (United States)

Author keywords

CopB; Moraxella catarrhalis; Surface epitope sequence variation; Vaccine

Indexed keywords

ALUMINUM PHOSPHATE; EPITOPE; MORAXELLA VACCINE; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN COPB; PHOSPHORYL LIPID A; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VACCINE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MOLECULAR CLONING; MORAXELLA CATARRHALIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VACCINATION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, SURFACE; BACTERIAL OUTER MEMBRANE PROTEINS; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; IMMUNE SERA; MICE; MORAXELLA (BRANHAMELLA) CATARRHALIS; POLYMORPHISM, GENETIC; RECOMBINANT PROTEINS;

EID: 33745806945     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2006.00093.x     Document Type: Article

References (26)

1. Aebi C, Stone B, Beucher M, et al. (1996) Expression of the CopB outer membrane protein by Moraxella catarrhalis is regulated by iron and affects iron acquisition from transferrin and lactoferrin. Infect Immun 64: 2024-2030.
2. Aebi C, Cope LD, Latimer JL, et al. (1998) Mapping of a protective epitope of the CopB outer membrane protein of Moraxella catarrhalis. Infect Immun 66: 540-548.
3. Ameen KA, Sethi S & Murphy TF (1998) Mapping of monoclonal antibodies 1F5 and 2.9F to the first variable region of CopB (OMP B2) of Moraxella catarrhalis. Program and abstracts of the 98th General Meeting of the American Society for Microbiology, Atlanta, GA.
4. Bakri F, Brauer AL, Sethi S & Murphy TF (2002) Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbations of chronic obstructive pulmonary disease. J Infect Dis 185: 632-640.
5. Bennett KE, Haggard MP, Silva PA & Stewart IA (2001) Behavior and developmental effects of otitis media with effusion into the teens. Arch Dis Child 85: 91-95.
6. Berner R, Schumacher RF, Brandis M & Forster J (1996) Colonization and infection with Moraxella catarrhalis in childhood. Eur J Clin Microbiol Infect Dis 15: 506-509.
7. Black AJ & Wilson TS (1988) Immunoglobulin G (IgG) serological response to Branhamella catarrhalis in patients with acute bronchopulmonary infections. J Clin Pathol 41: 329-333.
8. Bootsma HJ, van der Heide HG, van de Pas S, Schouls LM & Mooi FR (2000) Analysis of Moraxella catarrhalis by DNA typing: evidence for a distinct subpopulation associated with virulence traits. J Infect Dis 181: 1376-1387.
9. Campagnari AA, Shanks KL & Dyer SA (1994) Growth of Moraxella catarrhalis with human transferrin and lactoferrin: expression of iron-repressible proteins without siderophore production. Infect Immun 62: 4909-4914.
10. Carson SDB, Klebba PE, Newton SMC & Sparling PF (1999) Ferric enterobactin binding and utilization by Neisseria gonorrhoeae. J Bacteriol 181: 2895-2901.
11. Chapman AJ Jr, Musher DM, Jonsson S, Clarridge JE & Wallace RJ Jr (1985) Development of bactericidal antibody during Branhamella catarrhalis infection. J Infect Dis 115: 878-882.
12. Chen D, McMichael JC, VanDerMeid KR, et al. (1996) Evaluation of purified UspA from Moraxella catarrhalis as a vaccine in a murine model after active immunization. Infect Immun 64: 1900-1905.
13. Christensen J (1999) Moraxella (Branhamella) catarrhalis: clinical, microbiological and immunological features in lower respiratory tract infections. APMIS 107S: 1-36.
14. Faden H, Hong J & Murphy TF (1992) Immune response to outer membrane antigens of Moraxella catarrhalis in children with otitis media. Infect Immun 60: 3824-3829.
15. Helminen ME, Maciver I, Latimer JL, Cope LD, McCracken GH & Hansen EJ (1993a) A major outer membrane protein of Moraxella catarrhalis is a target for antibodies that enhance pulmonary clearance of the pathogen in an animal model. Infect Immun 61: 2003-2010.
16. Helminen ME, Maciver I, Paris M, et al. (1993b) A mutation affecting expression of a major outer membrane protein of Moraxella catarrhalis alters serum resistance and survival in vivo. J Infect Dis 168: 1194-1201.
17. Helminen E, Beach R, Maciver I, Jarosik G, Hansen EJ & Leinonen M (1995) Human immune response against outer membrane proteins of Moraxella (Branhamella) catarrhalis determined by immunoblotting and enzyme immunoassay. Clin Diagn Lab Immunol 2: 35-39.
18. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
19. Mathers K, Leinonen M & Goldblatt D (1999) Antibody response to outer membrane proteins of Moraxella catarrhalis in children with otitis media. Ped Infect Dis J 18: 982-988.
20. McMichael J (2001) Vaccines for Moraxella catarrhalis. Vaccine 19: S101-S107.
21. Meier PS, Freiburghaus S, Martin A, Neiniger N, Troller R & Aebi C (2003a) Mucosal immune response to specific outer membrane proteins of Moraxella catarrhalis in young children. Ped Infect Dis J 22: 256-262.
22. Meier PS, Heiniger N, Troller R & Aebi C (2003b) Salivary antibodies directed against outer membrane proteins of Moraxella catarrhalis in healthy adults. Infect Immun 71: 6793-6798.
23. Peterson GL (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83: 346-356.
24. Sethi S & Murphy TF (2001) Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev 14: 336-363.
25. Sethi S, Surface JM & Murphy TF (1997) Antigenic heterogeneity and molecular analysis of CopB of Moraxella (Branhamella) catarrhalis. Infect Immun 65: 3666-3671.
26. Towbin H, Staihelin T & Gordon J (1979) Electrophoretic transfer of proteins from acrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354.