Influence of charge and steric bulk in the C-24 region on the interaction of bile acids with human apical sodium-dependent bile acid transporter

Molecular Pharmaceutics

Volumn 3, Issue 3, 2006, Pages 282-292

  Balakrishnan, Anand ^a,c   Wring, Stephen A ^b   Coop, Andrew ^a   Polli, James E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Trimeris Inc   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bile acids; Cell culture; hASBT; Prodrugs; QSAR; SLC10A2; Transporters

Indexed keywords

ALPHA BENZYLGLUTAMIC ACID CHENODEOXYCHOLATAMIDE; ALPHA GAMMA DIBENZYLGLUTAMIC ACID CHENODEOXYCHOLATAMIDE; ALPHA GAMMA DIMETHYLGLUTAMIC ACID CHENODEOXYCHOLATAMIDE; ALPHA LYSINE BENZYL ESTER CHENODEOXYCHOLATAMIDE; ALPHA LYSINE CHENODEOXYCHOLATAMIDE; ALPHA LYSINE METHYL ESTER CHENODEOXYCHOLATAMIDE; ALPHA METHYL GAMMA TERT BUTYLGLUTAMIC ACID CHENODEOXYCHOLATAMIDE; ALPHA METHYLGLUTAMIC ACID CHENODEOXYCHOLATAMIDE; ALPHA TERT BUTYL GAMMA METHYLGLUTAMIC ACID CHENODEOXYCHOLATAMIDE; APICAL SODIUM DEPENDENT BILE ACID TRANSPORTER; BILE ACID; BILE ACID CONJUGATE; CHENODEOXYCHOLIC ACID DERIVATIVE; FUNCTIONAL GROUP; GAMMA BENZYLGLUTAMIC ACID CHENODEOXYCHOLATAMIDE; GAMMA METHYLGLUTAMIC ACID CHENODEOXYCHOLATAMIDE; GLUTAMIC ACID; GLUTAMIC ACID CHENODEOXYCHOLATAMIDE; LYSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; ION TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STEREOSPECIFICITY; SYNTHESIS;

BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; DRUG DESIGN; HUMANS; IONS; MOLECULAR CONFORMATION; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; SYMPORTERS;

EID: 33745799433     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp0600135     Document Type: Article

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