A finite mixture model for genotype and environment interactions: Detecting latent population heterogeneity

Twin Research and Human Genetics

Volumn 9, Issue 3, 2006, Pages 412-423

  Gillespie, Nathan A ^a   Neale, Michael C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMETRY; COVARIANCE; ENVIRONMENTAL FACTOR; FEASIBILITY STUDY; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; LATENT PERIOD; POPULATION GENETICS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; SCORING SYSTEM; SIMULATION; TWINS;

BIOMETRY; ENVIRONMENT; GENETICS, POPULATION; GENOTYPE; HUMANS; MODELS, GENETIC; MODELS, STATISTICAL; QUANTITATIVE TRAIT, HERITABLE; TWIN STUDIES; TWINS; VARIATION (GENETICS);

EID: 33745761031     PISSN: 18324274     EISSN: None     Source Type: Journal    
DOI: 10.1375/183242706777591380     Document Type: Review

References (29)

1. Bauer, D. J., & Curran, P. J. (2003). Distributional assumptions of growth mixture models: Implications for overextraction of latent trajectory classes. Psychological Methods, 8, 338-363.
2. Bishop, D. V. (2005). DeFries-Fulker analysis of twin data with skewed distributions: Cautions and recommendations from a study of children's use of verb inflections. Behavior Genetics, 35, 479-490.
3. Boomsma, D. I., de Geus, E. J., van Baal, G. C., & Koopmans, J. R. (1999). A religious upbringing reduces the influence of genetic factors on disinhibition: Evidence for interaction between genotype and environment on personality. Twin Research, 2, 115-125.
4. Brotherstone, S., & Hill, W. G. (1986). Heterogeneity of variances amongst herds for milk production. Animal Production, 48, 283-291.
5. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
6. DeFries, J. C., & Fulker, D. W. (1985). Multiple regression analysis of twin data. Behavior Genetics, 15, 467-473.
7. Eaves, L. J., & Sullivan, P. (2001). Genotype-environment interaction in transmission disequilibrium tests. Advances in Genetics, 42, 223-240.
8. Foulley, J. L., & Quaas, R. L. (1995). Heterogeneous variances in Gaussian linear mixed models. Genetics, Selection, Evolution, 27, 211-228.
9. Gianola, D., Foulley, J. L., Fernando, R. L., Henderson, C. R., & Weigel, K. A. (1992). Estimation of heterogeneous variances using empirical Bayes methods: Theoretical considerations. Journal of Dairy Science, 75, 2805-2823.
10. Heath, A. C., Eaves, L. J., & Martin, N. G. (1998). Interaction of marital status and genetic risk for symptoms of depression. Twin Research, 1, 119-122.
11. Kendler, K. S., & Eaves, L. J. (1986). Models for the joint effect of genotype and environment on liability to psychiatric illness. American Journal of Psychiatry, 143, 279-289.
12. Kendler, K. S., & Karkowski-Shuman, L. (1997). Stressful life events and genetic liability to major depression: Genetic control of exposure to the environment? Psychological Medicine, 27, 539-547.
13. Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1994). Parental treatment and the equal environment assumption in twin studies of psychiatric illness. Psychological Medicine, 24, 579-590.
14. LaBuda, M. C., DeFries, J. C., & Fulker, D. W. (1986). Multiple regression analysis of twin data obtained from selected samples. Genetic Epidemiology, 3, 425-433.
15. Lazarsfeld, P. F., & Henry, N. W. (1968). Latent structure analysis. Houghton Mifflin: Boston.
16. Lubke, G. H., & Muthén, B. (2005). Investigating population heterogeneity with factor mixture models. Psychological Methods, 10, 21-39.
17. Martin, N. G., Eaves, L. J., & Heath, A. C. (1987). Prospects for detecting genotype X environment interactions in twins with breast cancer. Acta Geneticae Medicae et Gemellologiae, 36, 5-20.
18. Martin, N. G., & Oakeshott, J. G. (1983). Is Pi a selectively balanced polymorphism? Human Heredity, 33, 24-28.
19. McLachlan, G. J., & Basford, K. E. (1988). Mixture models: Inference and applications to clustering. New York: Marcel Dekker.
20. Neale, M. C. (1999). Mx: Statistical modeling (5th ed.). Box 126 MCV, Richmond, VA 23298: Department of Psychiatry.
21. Neale, M. C. (2003). A finite mixture distribution model for data collected from twins. Twin Research, 6, 235-239.
22. Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic Publishers.
23. Neale, M. C., Cherny, S. S., Sham, P. C., Whiteld, J. B., Heath, A. C., Birley, A. C., & Martin, N. G. (1999). Distinguishing population stratification from genuine allelic effects with Mx: Association of ADH2 with alcohol consumption. Behavior Genetics, 29, 233-244.
24. Pearson, K. (1895). Contributions to the mathematical theory of evolution. II. Skew variation in homogeneous material. Philosophical Transactions of the Royal Society of London A, 343-414.
25. Purcell, S., & Sham, P. (2002). Variance components models for gene-environment interaction in quantitative trait locus linkage analysis. Twin Research, 5, 572-576.
26. Redner, R. A., & Walker, H. F. (1984). Mixture densities, maximum likelihood, and the EM algorithm. SIAM Review, 26, 195-239.
27. Titterington, D. M., Smith, A. F. M., & Makov, U. E. (1985). Statistical analysis of finite mixture distributions. Chicester: John Wiley & Sons.
28. Turkheimer, E., Haley, A., Waldron, M., D'Onofrio, B., & Gottesman, I. I. (2003). Socioeconomic status modifies heritability of IQ in young children. Psychological Science, 14, 623-628.
29. Vandenberg, S. G. (1984). Does a special twin situation contribute to similarity for abilities in MZ and DZ twins? Acta Geneticae Medicae et Gemellologiae, 33, 219-222.