Substrate utilization during prolonged exercise with ingestion of 13C-glucose in acute hypobaric hypoxia (4,300 m)

European Journal of Applied Physiology

Volumn 97, Issue 5, 2006, Pages 527-534

  Peronnet F ^a   Massicotte, Denis ^b   Folch, N ^a   Melin, B ^c   Koulmann, N ^c   Jimenez, C ^c   Bourdon, L ^c   Launay, J C ^c   Savourey, G ^c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^c CENTRE DE RECHERCHES   (France)

Author keywords

Altitude; Isotope; Nutrition

Indexed keywords

CARBOHYDRATE; CARBON 13; GLUCOSE;

ARTICLE; CALORIMETRY; CLINICAL ARTICLE; CYCLING; ENERGY YIELD; EXERCISE; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; HUMAN; HYPERVENTILATION; HYPOBARISM; HYPOXIA; LUNG GAS EXCHANGE; MALE; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SPIROMETRY; WORKLOAD;

ADULT; ANOXIA; ATMOSPHERE EXPOSURE CHAMBERS; ATMOSPHERIC PRESSURE; BLOOD GLUCOSE; CALORIMETRY, INDIRECT; CARBON ISOTOPES; EXERCISE; EXERCISE TEST; GLUCOSE; HUMANS; HYPERVENTILATION; MALE; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE;

EID: 33745755635     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-006-0164-2     Document Type: Article

References (36)

1. Beidleman BA, Rock PB, Muza SR, Fulco CS, Gibson LL, Kamimori GH, Cymerman A (2002) Substrate oxidation is altered in women during exercise upon acute altitude exposure Med Sci Sports Exerc 34:430-437
2. Bosch AN, Dennis SC, Noakes TD (1994) Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise J Appl Physiol 76:2364-2372
3. Bosch AN, Weltan SM, Dennis SC, Noakes TD (1996) Fuel substrate turnover and oxidation and glycogen sparing with carbohydrate ingestion in non-carbohydrate-loaded cyclists Pflugers Arch 432:1003-1010
4. Bouissou P, Guezennec CY, Defer G, Pesquies P (1987) Oxygen consumption, lactate accumulation, and sympathetic response during prolonged exercise under hypoxia Int J Sports Med 8:266-269
5. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT (1991a) Decreased reliance on lactate during exercise after acclimatization to 4,300 m J Appl Physiol 71:333-341
6. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT (1991b) Increased dependence on blood glucose after acclimatization to 4,300 m J Appl Physiol 70:919-927
7. Brooks GA, Wolfel EE, Groves BM, Bender PR, Butterfield GE, Cymerman A, Mazzeo RS, Sutton JR, Wolfe RR, Reeves JT (1992) Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m J Appl Physiol 72:2435-2445
8. Couture S, Massicotte D, Lavoie C, Hillaire-Marcel C, Peronnet F (2002) Oral [(13)C]glucose and endogenous energy substrate oxidation during prolonged treadmill running J Appl Physiol 92:1255-1260
9. Craig H (1953) The geochemistry of stable isotopes Geochem Cosmochem Acta 3:53-92
10. Derman KD, Hawley JA, Noakes TD, Dennis SC (1996) Fuel kinetics during intense running and cycling when fed carbohydrate Eur J Appl Physiol Occup Physiol 74:36-43
11. Friedmann B, Bauer T, Menold E, Bartsch P (2004) Exercise with the intensity of the individual anaerobic threshold in acute hypoxia Med Sci Sports Exerc 36:1737-1742
12. Fulco CS, Kambis KW, Friedlander AL, Rock PB, Muza SR, Cymerman A (2005) Carbohydrate supplementation improves time-trial cycle performance during energy deficit at 4300 m altitude. J Appl Physiol 99(3):867-876
13. 2 J Appl Physiol 74:133-138
14. Jeukendrup AE (2004) Carbohydrate intake during exercise and performance Nutrition 20:669-677
15. Jeukendrup AE, Jentjens R (2000) Oxidation of carbohydrate feedings during prolonged exercise: Current thoughts, guidelines and directions for future research Sports Med 29:407-424
16. Jeukendrup AE, Wallis GA (2005) Measurement of substrate oxidation during exercise by means of gas exchange measurements Int J Sports Med 26(Suppl 1):S28-S37
17. Jeukendrup AE, Wagenmakers AJ, Stegen JH, Gijsen AP, Brouns F, Saris WH (1999) Carbohydrate ingestion can completely suppress endogenous glucose production during exercise Am J Physiol 276:E672-E683
18. Jones NL, Jurkowski JE (1979) Body carbon dioxide storage capacity in exercise J Appl Physiol 46:811-815
19. Jones NL, Robertson DG, Kane JW, Hart RA (1972) Effect of hypoxia on free fatty acid metabolism during exercise J Appl Physiol 33:733-738
20. Larsen JJ, Hansen JM, Olsen NV, Galbo H, Dela F (1997) The effect of altitude hypoxia on glucose homeostasis in men J Physiol 504(Pt 1):241-249
21. Lefebvre PJ (1985) From plant physiology to human metabolic investigations Diabetologia 28:255-263
22. Lohman TG, Boileau RA, Massey BH (1975) Prediction of lean body mass in young boys from skinfold thickness and body weight Hum Biol 47:245-262
23. Lundby C, Van Hall G (2002) Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 m Acta Physiol Scand 176:195-201
24. Manore MM, Barr SI, Butterfield GE (2000) Joint position statement: nutrition and athletic performance. American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada Med Sci Sports Exerc 32:2130-2145
25. Massicotte D, Peronnet F, Adopo E, Brisson GR, Hillaire-Marcel C (1994) Effect of metabolic rate on the oxidation of ingested glucose and fructose during exercise Int J Sports Med 15:177-180
26. Massicotte D, Peronnet F, Pitre C, Adopo E, Brisson GR, Hillaire-Marcel C (1993) Exogenous 13C glucose oxidation during exercise: North American vs Western European studies Eur J Appl Physiol Occup Physiol 67:402-407
27. Pallikarakis N, Sphiris N, Lefebvre P (1991) Influence of the bicarbonate pool and on the occurrence of 13CO2 in exhaled air Eur J Appl Physiol Occup Physiol 63:179-183
28. Peronnet F, Massicotte D (1991) Table of nonprotein respiratory quotient: An update Can J Sport Sci 16:23-29
29. Pirnay F, Scheen AJ, Gautier JF, Lacroix M, Mosora F, Lefebvre PJ (1995) Exogenous glucose oxidation during exercise in relation to the power output Int J Sports Med 16:456-460
30. Pirnay F, Crielaard JM, Pallikarakis N, Lacroix M, Mosora F, Krzentowski G, Luyckx AS, Lefebvre PJ (1982) Fate of exogenous glucose during exercise of different intensities in humans J Appl Physiol 53:1620-1624
31. Rauch LH, Bosch AN, Noakes TD, Dennis SC, Hawley JA (1995) Fuel utilisation during prolonged low-to-moderate intensity exercise when ingesting water or carbohydrate Pflugers Arch 430:971-977
32. Roberts AC, Butterfield GE, Cymerman A, Reeves JT, Wolfel EE, Brooks GA (1996a) Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate J Appl Physiol 81:1762-1771
33. Roberts AC, Reeves JT, Butterfield GE, Mazzeo RS, Sutton JR, Wolfel EE, Brooks GA (1996b) Altitude and beta-blockade augment glucose utilization during submaximal exercise J Appl Physiol 80:605-615
34. 2] recovery from an oral glucose load during exercise: comparison between [U-13C] and [1,2-13C]glucose J Appl Physiol 95:477-482
35. 3 infusions Am J Physiol Endocrinol Metab 281:E683-E692
36. Young AJ, Evans WJ, Cymerman A, Pandolf KB, Knapik JJ, Maher JT (1982) Sparing effect of chronic high-altitude exposure on muscle glycogen utilization J Appl Physiol 52:857-862