Targeted ablation of the chromogranin A (Chga) gene: Normal neuroendocrine dense-core secretory granules and increased expression of other granins

Molecular Endocrinology

Volumn 20, Issue 8, 2006, Pages 1935-1947

  Hendy, Geoffrey N ^a   Li, Tong ^a   Girard, Martine ^a   Feldstein, Richard C ^a   Mulay, Shree ^a   Desjardins, Roxane ^c   Day, Robert ^c   Karaplis, Andrew C ^a   Tremblay, Michel L ^a,b   Canaff, Lucie ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CHROMOGRANIN A; CHROMOGRANIN B; DOPAMINE; GLYCOPROTEIN; NEUROTRANSMITTER; NORADRENALIN; PEPTIDE HORMONE;

ADRENAL GLAND; ARTICLE; BIOGENESIS; CHROMAFFIN CELL; GENE; GENE TARGETING; HORMONE RELEASE; MUTANT; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETORY GRANULE;

ADRENAL MEDULLA; ANIMALS; CATECHOLAMINES; CHROMOGRANIN A; CHROMOGRANINS; FEMALE; GENE DELETION; GENE EXPRESSION; GENE TARGETING; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEUROSECRETORY SYSTEMS; SECRETORY VESICLES; UP-REGULATION;

ANIMALIA;

EID: 33745747578     PISSN: 08888809     EISSN: 08888809     Source Type: Journal    
DOI: 10.1210/me.2005-0398     Document Type: Article

References (33)

1. Blaschko H, Comline RS, Schneider FH, Silver M, Smith AD 1967 Secretion of a chromaffin granule protein, chromogranin, from the adrenal gland after splanchnic stimulation. Nature 215:58-59
2. Helle KB 1973 Formation in vitro of matrix-like aggregates of chromogranins and phospholipids derived from chromaffin granules of the bovine adrenal medulla. Biochim Biophys Acta 318:181-196
3. Huttner WB, Gerdes HH, Rosa P 1991 The granin (chromogranin/ secretogranin) family. Trends Biochem Sci 16:27-30
4. Winkler H, Fischer-Colbrie R 1992 The chromogranins A and B: the first 25 years and future perspectives. Neuroscience 49:497-528
5. Feldman SA, Eiden LE 2003 The chromogranins: their roles in secretion from neuroendocrine cells and as markers for endocrine neoplasia. Endocr Pathol 14:3-23
6. Canaff L, Bennett HPJ, Hendy GN 1999 Peptide hormone precursor processing: getting sorted? Mol Cell Endocrinol 156:1-6
7. Helle KB, Aunis D, Eds. 2000 Chromogranins. Functional and clinical aspects. New York: Kluwer Academic/Plenum Publishers
8. Hendy GN, Bevan S, Mattei MG, Mouland AJ 1995 Chromogranin A. Clin Invest Med 18:47-65
9. Mouland AJ, Bevan S, White JH, Hendy GN 1994 Human chromogranin A gene: molecular cloning, structural analysis, and neuroendocrine cell-specific expression. J Biol Chem 269:6918-6926
10. Canaff L, Bevan S, Wheeler DG, Mouland AJ, Rehfuss RP, White JH, Hendy GN 1998 Analysis of molecular mechanisms controlling neuroendocrine cell specific transcription of the chromogranin A gene. Endocrinology 139:1184-1196
11. Murray S, Deaven LL, Burton DG, O'Connor DT, Mellon P, Deftos LJ 1987 The gene for human chromogranin A is located on human chromosome 14. Biochem Biophys Res Commun 142:141-146
12. Modi WS, Levine MA, Seuanez HN, Dean M, O'Brien SJ 1989 The human chromogranin A gene: chromosome assignment and RFLP analysis. Am J Hum Genet 45:814-818
13. Simon-Chazottes D, Wu H, Parmer RJ, Rozansky DJ, Szpirer J, Levan G, Kurtz TW, Szpirer C, Guenet JL, O'Connor DT 1993 Assignment of the chromogranin A (Chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6. Genomics 17:252-255
14. O'Connor DT, Takiyyuddin MA, Printz MP, Dinh TQ, Barbosa JA, Rozansky DJ, Mahata SK, Wu H, Kennedy BP, Ziegler MG, Wright FA, Schlager G, Parmer RJ 1999 Catecholamine storage vesicle protein expression in genetic hypertension. Blood Press 8:285-295
15. Mahapatra NR, O'Connor DT, Vaingankar SM, Sinha Hikim AP, Mahata M, Ray S, Staite E, Wu H, Gu Y, Dalton N, Kennedy BP, Ziegler MG, Ross Jr J, Mahata SK 2005 Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest 115:1942-1952
16. Kim T, Zhang C-F, Sun Z, Wu H, Loh YP 2005 Chromogranin A deficiency in transgenic mice leads to aberrant chromaffin granule biogenesis. J Neurosci 25:6958-6961
17. Barr FA, Short B 2003 Golgins in the structure and dynamics of the Golgi apparatus. Curr Opin Cell Biol 15:405-413
18. Short B, Haas A, Barr FA 2005 Golgins and GTPases, giving identity and structure to the Golgi apparatus. Biochim Biophys Acta 1744:383-395
19. Sun Y, Wilson MP, Majerus PW 2002 Inositol 1,3,4-trisphosphate 5/6 kinase associates with the COP9 signalosome by binding to CSN1. J Biol Chem 277:45759-45764
20. Lykke-Anderson K, Schaefer L, Menon S, Deng X-W, Miller JB, Wei N 2003 Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol 23:6790-6797
21. Kim T, Tao-Cheng JH, Eiden LE, Loh, YP 2001 Chromogranin A, an "on/off" switch controlling dense-core granule biogenesis. Cell 106:499-509
22. Huh YH, Jeon SH, Yoo SH 2003 Chromogranin B-induced secretory granule biogenesis. Comparison with the similar role of chromogranin A. J Biol Chem 278:40581-40589
23. Beuret N, Stettler H, Renold A, Rutishauser J, Speiss M 2004 Expression of regulated secretory proteins is sufficient to generate granule-like structures in constitutively secreting cells. J Biol Chem 279:20242-20249
24. Malosio ML, Giordano T, Laslop A, Meldolesi J 2004 Dense-core granules: a specific hallmark of the neuronal/neurosecretory cell phenotype. J Cell Sci 117:743-749
25. Day R, Gorr SU 2003 Secretory granule biogenesis and chromogranin A: master gene, on/off switch or assembly factor? Trends Endocrinol Metab 14:10-13
26. Gartner LP, Hiatt JL 1997 Endocrine system. In: Color textbook of histology. 1st ed. Chap 13. Philadelphia: W. B. Saunders Co.; 266
27. Tatemoto K, Efendic S, Mutt V, Makk G, Geistner GJ, Barchas JD 1986 Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature 324:476-478
28. 347-419), a novel chromogranin A-derived peptide, inhibits parathyroid cell secretion. Endocrinology 133:461-466
29. Mahata SK, Mahata M, Wen G, Wong WB, Mahapatra NR, Hamilton BA, O'Connor DT 2004 The catecholamine release-inhibitory "catestatin" fragment of chromogranin A: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses. Mol Pharmacol 66:1180-1191
30. Nagy A, Rossant J, Nagy R, Abramow-Newerley W, Roder JC 1993 Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 90:8424-8428
31. Canaff L, Petit J-L, Kisiel M, Watson PH, Gascon-Barre M, Hendy GN 2001 Extracellular calcium-sensing receptor is expressed in rat hepatocytes. Coupling to intracellular calcium mobilization and stimulation of bile flow. J Biol Chem 276:4070-4079
32. Laurent V, Jaubert-Miazza L, Desjardins R, Day R, Lindberg I 2004 Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice. Endocrinology 145:519-528
33. Deng XF, Mulay S, Chemtob S, Varma DR 1997 Mechanisms of the atrium-specific positive inotropic activities of quinidine- and atropine-like agents in rats. J Pharmacol Exp Therap 281:322-329