Desensitization for the management of clopidogrel hypersensitivity: Initial clinical experience

Journal of Invasive Cardiology

Volumn 18, Issue 7, 2006, Pages 341-344

  Walker, Nicholas E ^a   Fasano, Mary Beth ^a   Horwitz, Phillip A ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; ANTIHISTAMINIC AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CIMETIDINE; CLOPIDOGREL; DIPHENHYDRAMINE; DIPYRIDAMOLE; GLUCAGON; HEPARIN; HYDROXYZINE; LISINOPRIL; PREDNISONE; RANITIDINE; STEROID; TICLOPIDINE; WARFARIN;

ABDOMINAL CRAMP; ABDOMINAL PAIN; ADULT; AGED; ANGINA PECTORIS; ANGIONEUROTIC EDEMA; ARTERY THROMBOSIS; ARTICLE; BRAIN BLOOD VESSEL; CARDIOVASCULAR DISEASE; CHEST TIGHTNESS; CLINICAL ARTICLE; CORONARY BLOOD VESSEL; DESENSITIZATION; DIARRHEA; DRUG DOSE REDUCTION; DRUG ELUTING STENT; DRUG HYPERSENSITIVITY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; ERYTHEMA; FEMALE; FEVER; FLUSHING; GASTROINTESTINAL SYMPTOM; HEART INFARCTION; HUMAN; HYPOTENSION; INTENSIVE CARE UNIT; ISCHEMIC HEART DISEASE; MACULOPAPULAR RASH; MALE; NAUSEA; PATHOGENESIS; PATIENT MONITORING; PRURITUS; RESPIRATORY TRACT DISEASE; SIDE EFFECT; SKIN MANIFESTATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; TREATMENT RESPONSE; URTICARIA; VOMITING; WHEEZING;

ADULT; AGED; CEREBROVASCULAR ACCIDENT; CORONARY DISEASE; DESENSITIZATION, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG HYPERSENSITIVITY; EXANTHEMA; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE; TIME FACTORS;

EID: 33745747242     PISSN: 10423931     EISSN: 15572501     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Quinn MJ, Fitzgerald DJ. Ticlopidine and clopidogrel. Circulation 1999;100:1667-1672.
2. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996;348:1329-1339.
3. Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001;345:494-502.
4. Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001;358:527-533.
5. Steinhubl SR, Berger PB, Mann JT 3rd, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002;288:2411-2420.
6. Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 2005;352:1179-1789.
7. FDA Med Watch. October 2004.
8. Khambekar SK, Kovac J, Gershlick AH. Clopidogrel induced urticarial rash in a patient with left main stem percutaneous coronary intervention: Management issues. Heart 2004;90:e14.
9. Sarrot-Reynauld F, Bouillet L, Bourrain JL. Severe hypersensitivity associated with clopidogrel. Ann Intern Med 2001;135:305-306.
10. Fischer TC, Worm M, Groneberg DA. Clopidogrel-associated angioedema. Am J Med 2003;114:77-78.
11. Gowda RM, Misra D, Khan IA. Hypersensitivity skin rash: An adverse drug reaction to clopidogrel loading dose. Int J Cardiol 2004;95:333.
12. Vigo PG, MacDowell AL, Wedner HJ. Successful desensitization with clopidogrel after a positive skin test. Ann Allergy Asthma Immunol 2005;94:132.
13. Camara MG, Almeda FQ. Clopidogrel (Plavix) desensitization: A case series. Catheter Cardiovasc Interv 2005;65:525-527.
14. Gent M, Blakely JA, Easton JD, et al. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 1989;1:1215-1222.
15. Gill S, Majumdar S, Brown NE, Armstrong PW. Ticlopidine-associated pancytopenia: Implications of an acetylsalicylic acid alternative. Can J Cardiol 1997;13:909-913.
16. Page Y, Tardy B, Zeni F, et al. Thrombotic thrombocytopenic purpura related to ticlopidine. Lancet 1991;337:774-776.
17. Steinhubl SR, Tan WA, Foody JM, Topol EJ. Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting. JAMA 1999;281:806-810.
18. Bhatt DL, Topol EJ. Scientific and therapeutic advances in antiplatelet therapy. Nat Rev Drug Discov 2003;2:15-28.
19. Sharis PJ, Cannon CP, Loscalzo J. The antiplatelet effects of ticlopidine and clopidogrel. Ann Intern Med 1998;129:394-405.
20. Leon MB, Baim DS, Popma JJ, et al. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. N Engl J Med 1998;339:1665-1671.
21. MacGlashan D Jr LL. Basic characteristics of human lung mast cell desensitization. J Immunol 1987;139:501-505.
22. Naclerio R ME, Adkinson NF Jr. Immunologic observations during desensitization and maintenance of clinical tolerance to penicillin. J Allergy Clin Immunol 1983;71:294-301.
23. Sullivan TJ. Antigen-specific desensitization of patients allergic to penicillin. J Allergy Clin Immunol 1982;69:500-508.
24. Stark BJ, Earl HS, Gross GN, et al. Acute and chronic desensitization of penicillin-allergic patients using oral penicillin. J Allergy Clin Immunol 1987;79:523-532.
25. Sullivan TJ, Yecies LD, Shatz GS, et al. Desensitization of patients allergic to penicillin using orally administered beta-lactam antibiotics. J Allergy Clin Immunol 1982;69:275-282.
26. Turvey SE, Cronin B, Arnold AD, Dioun AF. Antibiotic desensitization for the allergic patient: 5 years of experience and practice. Ann Allergy Asthma Immunol 2004;92:426-432.
27. Absar N, Daneshvar H, Beall G. Desensitization to trimethoprim/ sulfamethoxazole in HIV-infected patients. J Allergy Clin Immunol 1994;93:1001-1005.
28. Berges-Gimeno MP, Stevenson DD. Nonsteroidal anti-inflammatory drug-induced reactions and desensitization. J Asthma 2004;41:375-384.
29. Wong JT, Nagy CS, Krinzman SJ, et al. Rapid oral challenge- desensitization for patients with aspirin-related urticaria-angioedema. J Allergy Clin Immunol 2000;105:997-1001.
30. Schaefer OP, Gore JM. Aspirin sensitivity: The role for aspirin challenge and desensitization in postmyocardial infarction patients. Cardiology 1999;91:8-13.
31. Silberman S, Neukirch-Stoop C, Steg PG. Rapid desensitization procedure for patients with aspirin hypersensitivity undergoing coronary stenting. Am J Cardiol 2005;95:509-510.