Intrathecal vs. intramuscular administration of human antitetanus immunoglobulin or equine tetanus antitoxin in the treatment of tetanus: A meta-analysis

Tropical Medicine and International Health

Volumn 11, Issue 7, 2006, Pages 1075-1081

  Kabura, L ^a   Ilibagiza, D ^a   Menten, J ^b   Van Den Ende, J ^a,b  

^a Teaching Hospital   (Rwanda)

^b INSTITUTE OF TROPICAL MEDICINE   (Belgium)

Author keywords

Equine tetanus antitoxin; Human antitetanus immunoglobulin; Intrathecal; Tetanus

Indexed keywords

TETANUS ANTIBODY;

DISEASE TREATMENT; HEALTH RISK; IMMUNIZATION; MEDICINE; META-ANALYSIS; MORTALITY; TETANUS;

ABSENCE OF SIDE EFFECTS; ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FOLLOW UP; HUMAN; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; META ANALYSIS; MORTALITY; PROGNOSIS; SYSTEMATIC REVIEW; TETANUS; TREATMENT OUTCOME;

ADULT; ANIMALS; HORSES; HUMANS; IMMUNOGLOBULINS; INFANT, NEWBORN; INJECTIONS, INTRAMUSCULAR; INJECTIONS, SPINAL; RANDOMIZED CONTROLLED TRIALS; TETANUS; TETANUS ANTITOXIN; TREATMENT OUTCOME;

EQUIDAE;

EID: 33745743487     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2006.01659.x     Document Type: Article

References (25)

1. Abrutyn E & Berlin JA (1991) Intrathecal therapy in tetanus. A meta-analysis. JAMA 266, 2262-2267.
2. Agarwal M, Thomas K, Peter JV, Jeyaseelan L & Cherian AM (1998) A randomized double-blind sham-controlled study of intrathecal human anti-tetanus immunoglobulin in the management of tetanus. The National Medical Journal of India 11, 209-212.
3. Attygalle D & Rodrigo N (2002) Magnesium as first line therapy in the management of tetanus: a prospective study of 40 patients. Anaesthesia 57, 811-817.
4. Attygalle D & Rodrigo N (2004) New trends in the management of tetanus. Expert Review of Anti-Infective Therapy 2, 73-84.
5. Bhandari B, Ajmera NK & Jagetiya PR (1980) Intrathecal anti-tetanus serum in management of tetanus neonatorum. The Indian Journal of Medical Research 72, 685-687.
6. Chopra K, Gupta A & Mhatre K (1986) Intrathecal tetanus hyperimmune human gamma globulin in the treatment of tetanus. Indian Pediatrics 23, 775-778.
7. Cucherat M, Boissel JP & Leizorovicz A (1997) La méta analyse des essaies thérapeutiques, Masson, Paris.
8. Deville WL, Buntinx F, Bouter LM et al. (2002) Conducting systematic reviews of diagnostic studies: didactic guidelines. BMC Medical Research Methodology 2, 9.
9. Diop-Mar I, Badianes S, Diague S, Stellmann C & Rey M (1975) Confirmation de l'efficacité de la sérothérapie intrathécale par une étude randomisée de 245 cas. Compte rendu de la 4ième conférence internationale sur le tétanos, Dakar, Senegal, pp. 641-645.
10. Gupta PS, Kapoor R, Goyal S, Batra VK & Jain BK (1980) Intrathecal human tetanus immunoglobulin in early tetanus. Lancet 2, 439-440.
11. van Houwelingen HC, Arends LR & Stijnen T (2002) Advanced methods in meta-analysis: multivariate approach and meta-regression. Acta Genetica et Statistica Medica 21, 589-624.
12. Ildirim I (1967) A new treatment for neonatal tetanus. Antitetanic serum and prednisolone given together intrathecally. The Turkish Journal of Pediatrics 9, 89-95.
13. Levin AS, Barone AA & Shiroma M (1987) Intrathecal serotherapy in tetanus (review). Revista do Instituto de Medicina Tropical de Sao Paulo 29, 255-267.
14. Mbise RL, Mongi PS, Msengi AE & Amsi DO (1984) Tetanus neonatorum - experience with intrathecal serotherapy at Muhimbili Medical Centre Dar es Salaam. East African Medical Journal 61, 892-895.
15. Menon J & Mathews L (2002) Intrathecal immunoglobulin in the treatment of tetanus. Indian Pediatrics 39, 654-657.
16. Mongi PS, Mbise RL, Msengi AE & Do Amsi DM (1987) Tetanus neonatorum - experience with intrathecal serotherapy at Muhimbili Medical Centre, Dar es Salaam, Tanzania. Annals of Tropical Paediatrics 7, 27-31.
17. Reddy VG (2002) Pharmacotherapy of tetanus - a review. Middle East Journal of Anesthesiology 16, 419-442.
18. Ribero R & Gayon A (2000) Le traitement du tétanos en zones rurales de l'Afrique de l'Est (RDC). Evaluation thérapeutique à propos de 21 cas. Médecine d'Afrique Noire 47, 141-147.
19. Robert R, Rouffineau J, Cremault A et al. (1984) Paraplégie réversible aprè injection intrathécale de fortes doses de gammaglobulines humaines lors du traitement de tétanos de faible gravité. Quatre observations. La Presse Médicale 13, 1947-1979.
20. Sanders RK, Martyn B, Joseph R & Peacock ML (1977) Intrathecal antitetanus serum (horse) in the treatment of tetanus. Lancet 1, 974-977.
21. Sedaghatian MR (1979) Intrathecal serotherapy in neonatal tetanus: a controlled trial. Archives of Disease in Childhood 54, 623-625.
22. Singh AK, Bansal A, Goel SP & Agarwal VK (1980) Intrathecal antitetanus serum (horse) with steroid in the treatment of neonatal tetanus. Archives of Disease in Childhood 55, 527-531.
23. Sutton DN, Tremlett MR, Woodcock TE & Nielsen MS (1990) Management of autonomie dysfunction in severe tetanus: the use of magnesium sulphate and clonidine. Journal of Intensive Care Medicine 16, 75-80.
24. Thwaites CL, Yen LM, Nga NT et al. (2004) Impact of improved vaccination programme and intensive care facilities on incidence and outcome of tetanus in southern Vietnam, 1993-2002. Transactions of the Royal Society of Tropical Medicine and Hygiene 98, 671-677.
25. Vakil BJ, Armitage P, Clifford RE & Laurence DR (1979) Therapeutic trial of intracisternal human tetanus immunoglobulin in clinical tetanus. Transactions of the Royal Society of Tropical Medicine and Hygiene 73, 579-583.