An efficient, stereoselective synthesis of the hydroxyethylene dipeptide isostere core for the HIV protease inhibitor A-792611

Journal of Organic Chemistry

Volumn 71, Issue 14, 2006, Pages 5369-5372

  Engstrom, Kenneth ^a   Henry, Rodger ^a   Hollis, L Steven ^a   Kotecki, Brian ^a   Marsden, Ian ^a   Pu, Yu Ming ^a   Wagaw, Seble ^a   Wang, Weifeng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIASTEREOMERICALLY; HOFMANN REARRANGEMENTS; KINETIC PROTONATION; LACTONE;

ALCOHOLS; ENZYME INHIBITION; REACTION KINETICS; STEREOCHEMISTRY; SUBSTRATES; SYNTHESIS (CHEMICAL);

PROTEINS;

[4 AMINO 1 BENZYL 2 HYDROXY 5 (4 PYRIDIN 2 YLPHENYL)PENTYL]CARBAMIC ACID TERT BUTYL ESTER; A 792611; AMINOALCOHOL; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; EPOXIDE; LACTONE; PHENYLALANINE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PROTEINASE INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; ESTERS; HIV PROTEASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIDINES; STEREOISOMERISM;

EID: 33745728268     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo060737s     Document Type: Article

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