Expression of the glutathione enzyme system of human colon mucosa by localisation, gender and age

Current Medical Research and Opinion

Volumn 22, Issue 6, 2006, Pages 1075-1083

  Hoensch, Harald ^a,d   Peters, W H M ^b   Roelofs, H M J ^b   Kirch, W ^c  

^a General Hospital of Gross Gerau   (Germany)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d Kreiskrankenhaus   (Germany)

Author keywords

Age; Carcinogenesis; Colon; Colon cancer; Gender; Glutathione; Glutathione S transferase

Indexed keywords

GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1;

ADULT; ARTICLE; COLON BIOPSY; COLON MUCOSA; COLONOSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMALE; HORMONE SUBSTITUTION; HUMAN; MALE; NORMAL HUMAN; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; COLON, TRANSVERSE; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; INCIDENCE; INTESTINAL MUCOSA; MALE; MIDDLE AGED; NEOPLASM PROTEINS; RETROSPECTIVE STUDIES; SEX FACTORS;

EID: 33745714083     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079906X112480     Document Type: Article

References (40)

1. Gupta AK, Melton LJ, Petersen GM, et al. Changing trends in the incidence, stage, survival, and screen detection of colorectal cancer: a population-based study. Clin Gastroenterol Hepatol 2005;3:150-8
2. Lieberman DA, Holub J, Eisen G, et al. Prevalence of polyps greater than 9 mm in a consortium of diverse clinical practice settings in the United States. Clin Gastroenterol Hepatol 2005;3:798-805
3. Hoensch H, Hartmann F. The intestinal biotransformation system: potential role in protection from colon cancer: Hepatogastroenterology 1981;28:221-8
4. Cotton SC, Sharp L, Little J, Brockton N. Glutathione S-transferase polymorphisms and colorectal cancer: A HuGE review. Am J Epidemiol 2000;151:7-31
5. Peters WHM, Roelofs HMJ, Nagengast FM, van Tongeren JHM. Human intestinal glutathione S-transferases. Biochem J 1989;257:471-6
6. Raijmakers MTM, Zusterzeel PLM, Steegers EAP, et al. Plasma thiol status in preeclampsia. Obstetric Gynecol 2000;95:180-4
7. Wilkinson IV J, Clapper ML. Detoxification enzymes and chemoprevention. Proc Soc Exp Biol Med 1997;216:192-200
8. Van Lieshout EMM, Posner GH, Woodard BT, Peters WHM. Effects of sulforaphane analog compound-30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract. Biochim Biophys Acta 1998;1379:325-36
9. Grubben MJAL, van den Braak CCM, Peters WHM, et al. Low levels of colonic glutathione S-transferase in patients with linked agammaglobulinaemia. Eur J Clin Invest 2000;30:642-5
10. Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol 1995;30:445-600
11. Clapper ML, Hoffmann SJ, Carp N, et al. Contribution of patient history to the glutathione S-transferase activity of human lung, breast and colon tissue. Carcinogenesis 1991;12:1957-61
12. Mulder TPJ, Peters WHM, Wobbes T, et al. Measurement of glutathione S-transferase P 1-1 in plasma; pitfalls and significance for screening and follow-up of patients with gastrointestinal carcinoma. Cancer 1997;80:873-80
13. Lang CA, Narishkin S, Schneider DL, et al. Low blood glutathione levels in healthy ageing adults. J Lab Clin Med 1992;120:720-5
14. Singhal SS, Saxena M, Awasthi S, et al. Gender related differences in the expression and characteristics of glutathione S-transferases of human colon. Biochim Biophys Acta 1992;1171:19-26
15. Singhal SS, Saxena M, Awasthi S, et al. Glutathione S-transferases of human skin: qualitative and quantitative differences in men and women. Biochim Biophys Acta 1993;1163:266-72
16. Peters WHM, Nagengast FM, van Tongeren JHM. Glutathione S-transferase, cytochrome P450 and uridine 5′-diphosphate-glucuronaryltransferase in human small intestine and liver. Gastroenterology 1989;96:783-9
17. Ogasawara T, Hoensch HP, Ohnhaus EE. Distribution of glutathione and its related enzymes in small intestinal mucosa of rats. Arch Toxicol Suppl 1985;8:110-3
18. Coles BF, Chen G, Kadlubar FF, Radominska-Pandya A. Interindividual variation and organ-specific pattern of glutathione S-transferase alpha, mu, and pi expression in the gastrointestinal tract mucosa of normal individuals. Arch Biochem Biophys 2002;403:270-6
19. Peters WHM, Kock L, Nagengast FM, Kremers PG. Biotransformation enzymes in human intestine: critical low levels in the colon. Gut 1991;32:408-12
20. Clapper ML, Hoffmann SJ, Tew KD. Glutathione S-transferase in normal and malignant human colon tissue. Biochim Biophys Acta 1991;1096:209-16
21. Siegers CP, Böse-Younes H, Thies E, et al. Glutathione and GSH-dependent enzymes in the tumorous and nontumorous mucosa of the human colon and rectum. J Cancer Res Clin Oncol 1984;107:238-41
22. Lowry OH, Rosebrough NJ, Farr AL, Randal RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-75
23. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-9
24. Fortin LJ, Genest J. Measurement of homocysteine in the prediction of arteriosclerosis. Clin Biochem 1995;28:155-62
25. Batist G, Meckhail-Ishak K, Hudson N, DeMuys JM. Interindividual variation in phase II detoxification enzymes in normal human colon mucosa. Biochem Pharmacol 1988;37:4241-3
26. Szarka CE, Pfeiffer GR, Hum ST, et al. Glutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer. Cancer Res 1995;55:2789-93
27. Treptow-van Lishaut S, Beckemmer G, et al. The carbohydrate crystalean and colonic microflora modulate expression of glutathione S-transferase subunits in colon of rats. Eur J Nutr 1999;38:76-83
28. Mulder TPJ, Verspaget HW, Sier CFM, et al. Glutathione S-transferase π in colorectal tumors is predictive for overall survival. Cancer Res 1955;55:2696-702
29. Butler RN, Butler WJ, Moraby Z, et al. Glutathione concentrations and glutathione S-transferase activity in human colonic neoplasms. J Gastroenterol Hepatol 1994;9:60-3
30. Hoensch H, Morgenstern I, Petereit G, et al. Influence of clinical factors, diet, and drugs on the human upper gastrointestinal glutathione system. Gut 2002;50:235-0
31. Wark PA, Grubben MJAL, Peters WHM, et al. Habitual consumption of fruits and vegetables: associations with human rectal glutathione S-transferase. Carcinogenesis 2004;25:2135-2
32. Sharma R, Ahmad H, Singhal SS, et al. Comparative studies on the effect of butylated hydroxyanisole on glutathione and glutathione S-transferases in the tissues of male and female CD-1 mice. Comp Biochem Physiol 1993;105:31-7
33. Mitchell AE, Morin D, Lakritz J, Jones AD. Quantitative profiling of tissue- and gender-related expression of glutathione S-transferase isoenzymes in the mouse. Biochem J 1997;325: 207-16
34. Murray M, Cantrill E. Sex- and substrate-dependent changes in hepatic cytosolic glutathione S-transferase enzymes produced by dietary choline deficiency. Carcinogenesis 1988;9:451-6
35. Greenspan FS, Baxter JD. Endocrinology basic & clinical, 4th ed. East Norwalk (UK): Appleton & Lange; 1994
36. Korenman SG, Morley JE, Mooradian AD, et al. Secondary hypogonadism in older men: its relation to impotence. J Clin Endocrinol Metab 1990;71:963-9
37. Hatayama I, Satoh K, Sato K. Developmental and hormonal regulation of the major form of hepatic glutathione S-transferase in male mice. Biochim Biophys Res Commun 1986;140:581-8
38. Singhal SS, Saxena M, Ahmad H, Awasthi YC. Glutathione S-transferases of mouse liver: sex-related differences in the expression of various isoenzymes. Biochim Biophys Acta 1992;1116:137-46
39. van Lieshout EMM, Peters WHM. Age and gender dependent levels of glutathione and glutathione S-transferases in human lymphocytes. Carcinogenesis 1998;19:1873-5
40. Richi JP, Skowronski L, Abraham P, Leutzinger Y. Blood glutathione concentrations in a large-scale human study. Clin Chem 1996;42:64-70