Growth promoting in vitro effect of synthetic cyclic RGD-peptides on human osteoblast-like cells attached to cancellous bone

International Journal of Molecular Medicine

Volumn 17, Issue 6, 2006, Pages 1017-1021

  Magdolen, Ursula ^a   Auernheimer, Jörg ^c   Dahmen, Claudia ^c   Schauwecker, Johannes ^a   Gollwitzer, Hans ^a   Tübel, Jutta ^a   Gradinger, Reiner ^a   Kessler, Horst ^c   Schmitt, Manfred ^b   Diehl, Peter ^a  

^a Department of Orthopedic Surgery ^*  (Germany)

^b Clinical Research Unit   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cell adherence; Cell growth; Human bone; Osteoblast like cells; RGD peptide

Indexed keywords

CYCLOPEPTIDE; PHOSPHONIC ACID DERIVATIVE; RGD 1 COMPOUND; RGD 2 COMPOUND; RGD-1 COMPOUND; RGD-2 COMPOUND;

ARTICLE; BONE; CELL ADHESION; CELL PROLIFERATION; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; HUMAN; METHODOLOGY; OSTEOBLAST; TISSUE ENGINEERING;

BONE AND BONES; CELL ADHESION; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; HUMANS; OSTEOBLASTS; PEPTIDES, CYCLIC; PHOSPHONIC ACIDS; TISSUE ENGINEERING;

EID: 33745699559     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.6.1017     Document Type: Article

References (44)

1. Araki N, Myoui A, Kuratsu S, et al: Intraoperative extra-corporeal autogenous irradiated bone grafts in tumor surgery. Clin Orthop 368: 196-206, 1999. (Pubitemid 29533995)
2. Boehm P, Springfeld R and Springer H: Re-implantation of autoclaved bone segments in musculoskeletal tumor surgery: clinical experience in 9 patients followed for 1.1-8.4 years and review of the literature. Arch Orthop Trauma Surg 118: 57-65, 1998.
3. Boehm P, Fritz J, Thiede S and Budach W: Reimplantation of extracorporeal irradiated bone segments in musculoskeletal tumor surgery: clinical experience in eight patients and review of the literature. Langenbecks Arch Surg 387: 355-365, 2003.
4. Hornicek FJ, Gebhardt MC, Tomford WW, Sorger JI, Zavatta M, Menzner JP and Mankin HJ: Factors affecting non-union of the allograft-host junction. Clin Orthop 382: 87-98, 2001.
5. Sorger JI, Hornicek FJ, Zavatta M, Menzner JP, Gebhardt MC, Tomford WW and Mankin HJ: Allograft fractures revisited. Clin Orthop 382: 66-74, 2001.
6. Sugimoto M, Takahashi S, Toguchida J, Kotoura Y, Shibamoto Y and Yamamuro T: Changes in bone after high-dose irradiation biomechanics and histomorphology. J Bone Joint Surg Br 73: 492-497, 1991.
7. Zoricic S, Bobinac D, Lah B, et al: Study of the healing process after transplantation of pasteurized bone grafts in rabbits. Acta Med Okayama 56: 121-128, 2002. (Pubitemid 135689608)
8. Diehl P, Schmitt M, Bluemelhuber G, et al: Induction of tumor cell death by high hydrostatic pressure as a novel supporting technique in orthopedic surgery. Oncol Rep 10: 1851-1855, 2003.
9. Diehl P, Reuning U, Gollwitzer H, et al: Effect of extracorporal high hydrostatic pressure on tumor cell adherence and viability. Oncol Rep 12: 369-373, 2004.
10. Naal F-D, Mengele K, Schauwecker J, et al: High hydrostatic pressure-induced cell death in human chondrocytes and chondrosarcoma cells. Anticancer Res 25: 1977-1982, 2005.
11. Diehl P, Schmitt M, Schauwecker J, et al: Effect of high hydrostatic pressure on biological properties of extracellular bone matrix proteins. Int J Mol Med 16: 285-289, 2005.
12. Steinhauser E, Diehl P, Hadaller M, Schauwecker J, Busch R, Gradinger R and Mittelmeier W: Biochemical investigation of the effect of high hydrostatic pressure treatment on the mechanical properties of human bone. J Biomed Mater Res 76B: 130-135, 2006.
13. Anselme K: Osteoblast adhesion on biomaterials. Biomaterials 21: 667-681, 2000.
14. Hersel U, Dahmen C and Kessler H: RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 24: 4385-4415, 2003.
15. Shin H, Temenoff JS, Bowden GC, Zygourakis K, Farach- Carson MC, Yaszemski MJ and Mikos AG: Osteogenic differentiation of rat bone marrow stromal cells cultured on Arg-Gly-Asp modified hydrogels without dexamethasone and betaglycerol phosphate. Biomaterials 26: 3645-3654, 2005. (Pubitemid 40038159)
16. Schaffner P and Dard MM: Structure and function of RGD peptides involved in bone biology. Cell Mol Life Sci 60: 119-132, 2003.
17. Auernheimer J, Zukowski D, Dahmen C, Kantlehner M, Enderle A, Goodman L and Kessler H: Titanium implant materials with improved biocompatibility via coating with phosphonate-anchored cyclic RGD-peptides. Chembiochem 6: 2034-2040, 2005.
18. Pfaff M, Tangemann K, Mueller B, et al: Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins. J Biol Chem 269: 20233-20238, 1994.
19. vβ3 antagonists. J Am Chem Soc 118: 7461-7472, 1996.
20. Aumailley M, Gurrath M, Müller G, Calvete J, Timpl R and Kessler H: Arg-Gly-Asp constrained within cyclic pentapeptides strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1. FEBS Lett 291: 50-54, 1991.
21. Auernheimer J and Kessler H: Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium. Bioorg Med Chem Lett 16: 271-273, 2005.
22. Barlos K, Gatos D, Kallitsis J, Papaphotiu G, Sotiru P, Weqing Y and Schäffer W: Darstellung geschützter Peptid-Fragmente unter Einsatz substituierter Triphenylmethyl-Harze. Tetrahedron Lett 30: 3943-3946, 1989. (Pubitemid 19205781)
23. Fields GB and Noble RL: Solid-phase peptide-synthesis utilizing 9-fluorenylmethoxycarbonyl amino-acids. Int J Pept Protein Res 35: 161-214, 1990.
24. Kantlehner M, Schaffner P, Finsinger D, et al: Surface coating with cyclic RGD peptides stimulates osteoblast adhesion and proliferation as well as bone formation. Chembiochem 1: 107-114, 2000.
25. Landegren U: Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens. J Immunol Methods 67: 379-388, 1984.
26. Gronowicz G and McCarthy MB: Response of human osteoblasts to implant materials: integrin-mediated adhesion. J Orthop Res 14: 878-887, 1996. (Pubitemid 27044455)
27. Kantlehner M, Finsinger D, Meyer J, et al: Adhesion of osteoblasts at surfaces of implants. Angew Chem Int Ed Engl 38: 560-562, 1999.
28. Schaffner P, Meyer J, Dard M, et al: Induced tissue integration of bone implants by coating with bone selective RGD-peptides in vitro and in vivo studies. J Mater Sci Mater Med 10: 837-839, 1999.
29. Ferris DM, Moodie GD, Dimond PM, Gioranni PM, Ehrlich MG and Valentini RF: RGD-coated titanium implants stimulate increased bone formation in vivo. Biomaterials 20: 2323-2331, 1999.
30. Jeschke B, Meyer J, Jonczyk A, et al: RGD-peptides for tissue engineering of articular cartilage. Biomaterials 23: 3455-3463, 2002.
31. Schliephake H, Scharnweber D, Dard M, Rössler S, Sewing A, Meyer J and Hoogestraat D: Effect of RGD peptide coating of titanium implants on peri-implant bone formation in the alveolar crest. An experimental pilot study in dogs. Clin Oral Impl Res 13: 312-319, 2002.
32. Dahmen C, Auernheimer J, Meyer A, Enderle A, Goodman SL and Kessler H: Improving implant materials by coating with non-peptidic, highly specific integrin ligands. Angew Chem Int Ed Engl 43: 6649-6652, 2004. (Pubitemid 40018989)
33. Elmengaard B, Bechtold JE and SØalle K: In vivo study of the effect of RGD treatment on bone ongrowth on press-fit titanium alloy implants. Biomaterials 26: 3521-3526, 2005.
34. Steinhauser E, Liebendörfer A, Enderle A, et al: In vivo-Studie zu knöchernen Integration von RGD-Peptid beschichteten und unbeschichteten metallischen Implantaten. MP Materialprüfung 4: 197-202, 2005.
35. Hofmann A, Hofmann C and Gotzen L: Effect of various bone disinfection and sterilization methods on osteoblast function. A comparative in vitro study. Unfallchirurg 103: 380-388, 2000.
36. Longhurst CM and Jennings LK: Integrin-mediated signal transduction. Cell Mol Life Sci 54: 514-526, 1998.
37. Rezania A and Healy KE: Integrin subunits responsible for adhesion of human osteoblast-like cells to biomimetic peptide surfaces. J Orthop Res 17: 615-623, 1999. (Pubitemid 29383625)
38. Wester HJ and Kessler H: Molecular targeting with peptides or peptide-polymer-conjugates: just a question of size? J Nucl Med 6: 1940-1945, 2005.
39. Gottschalk KE and Kessler H: A computational model of transmembrane integrin clustering. Structure 12: 1109-1116, 2004.
40. Li W, Metcalf DG, Gorelik R, et al: A push-pull mechanism for regulating integrin function. Proc Natl Acad Sci USA 102: 1424-1429, 2005.
41. Cowles EA, Brailey LL and Gronowicz GA: Integrin-mediated signaling regulates AP-1 transcription factors and proliferation in osteoblasts. J Biomed Mater Res 52: 725-737, 2000.
42. Geissler U, Hempel U, Wolf C, Scharnweber D, Worch H and Wenzel K: Collagen type I-coating of Ti6Al4V promotes adhesion of osteoblasts. J Biomed Mater Res 51: 752-760, 2000.
43. Schauwecker J, Diehl P, Bauer D, et al: High hydrostatic pressure treatment of bone tissue with subsequent revitalization. Biomaterialien 6: 125, 2005.
44. Holland J, Hersh L, Bryhan M, Onyiriuka E and Ziegler L: Culture of human vascular endothelial cells on an RGD-containing synthetic peptide attached to a starch-coated polystyrene surface: comparison with fibronectin-coated tissue grade polystyrene. Biomaterials 17: 2147-2156, 1996.