Chronic contamination with 137Cesium affects Vitamin D3 metabolism in rats

Toxicology

Volumn 225, Issue 1, 2006, Pages 75-80

  Tissandie, E ^a   Gueguen Y ^a   Lobaccaro, J M A ^b   Aigueperse, J ^a   Gourmelon, P ^a   Paquet, F ^a   Souidi, M ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Cesium; Cytochrome P450; Rat; Vitamin D3

Indexed keywords

CELL NUCLEUS RECEPTOR; CESIUM 137; COLECALCIFEROL; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; DRINKING WATER; MESSENGER RNA; PARATHYROID HORMONE; CESIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BONE METABOLISM; BRAIN; BRAIN METABOLISM; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; HOMEOSTASIS; HORMONE BLOOD LEVEL; KIDNEY; LIVER; LIVER METABOLISM; LONG TERM EXPOSURE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; TIME SERIES ANALYSIS; USSR; VITAMIN BLOOD LEVEL; VITAMIN D METABOLISM; WATER CONTAMINATION; ANIMAL; CHERNOBYL ACCIDENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RADIATION EXPOSURE; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; CESIUM RADIOISOTOPES; CHERNOBYL NUCLEAR ACCIDENT; CHOLECALCIFEROL; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KIDNEY; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 33745685849     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.05.006     Document Type: Article

References (26)

1. Anderson P.H., O'Loughlin P.D., May B.K., and Morris H.A. Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase-polymerase chain reaction. J. Mol. Endocrinol. 31 (2003) 123-132
2. Bandazhevskaya G.S., Nesterenko V.B., Babenko V.I., Yerkovich T.V., and Bandazhevsky Y.I. Relationship between caesium (137Cs) load, cardiovascular symptoms, and source of food in 'Chernobyl' children-preliminary observations after intake of oral apple pectin. Swiss Med. Wkly. 134 (2004) 725-729
3. Bandazhevsky Y.I. Chronic Cs-137 incorporation in children's organs. Swiss. Med. Wkly. 133 (2003) 488-490
4. Cherenko S.M., Larin O.S., Gorobeyko M.B., and Sichynava R.M. Clinical analysis of thyroid cancer in adult patients exposed to ionizing radiation due to the Chernobyl nuclear accident: 5-year comparative investigations based on the results of surgical treatment. World J. Surg. 28 (2004) 1071-1074
5. Dusso A.S., Brown A.J., and Slatopolsky E. Vitamin D. Am. J. Physiol. Renal Physiol. 289 (2005) F8-F28
6. Fritz, T., 1972. Cesium 137 late effects of single intravenous injections in beagles. ANL 7970, Argone National Laboratory Annual Report, pp. 206-208.
7. Garcion E., Wion-Barbot N., Montero-Menei C.N., Berger F., and Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol. Metab. 13 (2002) 100-105
8. Handl J., Beltz D., Botsch W., Harb S., Jakob D., Michel R., and Romantschuk L.D. Evaluation of radioactive exposure from 137Cs in contaminated areas of Northern Ukraine. Health Phys. 84 (2003) 502-517
9. 2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. FASEB J. 16 (2002) 1398-1406
10. Holick M.F. Vitamin D: a millenium perspective. J. Cell Biochem. 88 (2003) 296-307
11. Ivanov V.K., Maksioutov M.A., Chekin S., Kruglova Z.G., Petrov A.V., and Tsyb A.F. Radiation-epidemiological analysis of incidence of non-cancer diseases among the Chernobyl liquidators. Health Phys. 78 (2000) 495-501
12. Kharchenko V.P., Rassokhin B.M., and Zubovskii G.A. Value of bone densitometry in the determination of vertebral mineral density in participants of the clean-up after Chernobyl accident. Med. Tr. Prom. Ekol. (2001) 29-32
13. Likhtarov, I., Kovgan, L., Vavilov, S., Chepurny, M., Bouville, A., Luckyanov, N., Jacob, P., Voilleque, P., Voigt, G., 2005. Post-Chernobyl thyroid cancers in Ukraine. Report 1: estimation of thyroid doses. Radiat. Res. 163, 125-136.
14. Liubchenko P.N., Kovaleva L.I., Nikolaeva A.P., Bendikov E.A., Dubinina E.B., and Ol'shanskii V.A. Intrahepatic circulation in participants of clean-up after the Chernobyl Atomic Energy Plant accident. Med. Tr. Prom. Ekol. (1994) 15-17
15. Messiha F.S. Lithium, rubidium and cesium: cerebral pharmacokinetics and alcohol interactions. Pharmacol. Biochem. Behav. 21 Suppl. 1 (1984) 87-92
16. 137Cs in residents around the Chernobyl nuclear power plant. Radiat. Prot. Dosimetry 113 (2005) 326-329
17. Romanenko A., Morell-Quadreny L., Nepomnyaschy V., Vozianov A., and Llombart-Bosch A. Radiation sclerosing proliferative atypical nephropathy of peritumoral tissue of renal-cell carcinomas after the Chernobyl accident in Ukraine. Virch. Arch. 438 (2001) 146-153
18. Ropenga A., Chapel A., Vandamme M., and Griffiths N.M. Use of reference gene expression in rat distal colon after radiation exposure: a caveat. Radiat. Res. 161 (2004) 597-602
19. Rozhinskaia L., Marova E.I., Rassokhin B.M., Purtova G.S., Bukhman A.I., Oganov V.S., Rakhmanov A.S., Bakulin A.V., Rodionova S.S., and Mishchenko B.P. Osteopenic syndrome in liquidators of the aftereffects of the accident at the Chernobyl power plant. Prob. Endokrinol. (Mosk) 40 (1994) 24-27
20. Schwaiger M., Mueck K., Benesch T., Feichtinger J., Hrnecek E., and Lovranich E. Investigation of food contamination since the Chernobyl fallout in Austria. Appl. Radiat. Isot. 61 (2004) 357-360
21. 2+ metabolism in the blood cells of cattle with radiation-induced thyroid disorder after the Chernobyl nuclear power plant accident. Radiat. Biol. Radioecol. 33 (1993) 775-782
22. Shkala L.V. Metabolic disorders in digestive and hepatobiliary pathology in those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station. Lik Sprava (1998) 42-45
23. Souidi M., Gueguen Y., Linard C., Dudoignon N., Grison S., Baudelin C., Marquette C., Gourmelon P., Aigueperse J., and Dublineau I. In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. Toxicology 214 (2005) 113-122
24. Tissandie, E., Gueguen, Y., Lobaccaro, J.M., Paquet, F., Aigueperse, J., Souidi, M., 2006. Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat. Arch. Toxicol.
25. Vilic M., Barisic D., Kraljevic P., and Lulic S. 137Cs concentration in meat of wild boars (Sus scrofa) in Croatia a decade and half after the Chernobyl accident. J. Environ. Radioact. 81 (2005) 55-62
26. Vykhovanets E.V., Chernyshov V.P., Slukvin I.I., Antipkin Y.G., Vasyuk A., and Colos V. Analysis of blood lymphocyte subsets in children living around Chernobyl exposed long-term to low doses of cesium-137 and various doses of iodine-131. Radiat. Res. 153 (2000) 760-772