Pharmacokinetics of intravenously administered caffeine in healthy alpacas (Lama pacos) and Ilamas (Lama glama)

American Journal of Veterinary Research

Volumn 67, Issue 6, 2006, Pages 1063-1069

  Lakritz, Jeffrey ^a,b   Middleton, John R ^a   Anderson, David E ^b   Linden, Daniel R ^b   Sams, Richard A ^b   Tessman, Ronald K ^a   Tyler, Jeff W ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE;

ARTICLE; ARTIODACTYLA; BOLUS INJECTION; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEAN RESIDENCE TIME; NONHUMAN; STEADY STATE;

ANIMALS; CAFFEINE; CAMELIDS, NEW WORLD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HALF-LIFE; HEALTH; INJECTIONS, INTRAVENOUS; MALE; SPECIES SPECIFICITY;

ANIMALIA; CAMELIDAE; LAMA (MAMMAL); LAMA GLAMA; LAMA PACOS;

EID: 33745675103     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.67.6.1063     Document Type: Article

References (30)

1. Van Saun RJ, Callihan BR, Tornquist SJ. Nutritional support for treatment of hepatic lipidosis in a llama. J Am Vet Med Assoc 2000;217:1531-1535
2. Anderson DE, Constable PD, Yvorchuk KE, et al. Hyperlipemia and ketonuria in an alpaca and a llama. J Vet Intern Med 1994;8:207-211
3. Jonsson NN, Rozmanec M. Tick paralysis and hepatic lipidosis in a llama. Aust Vet J 1997;75:250-253.
4. Semrad SD. Septicemic listeriosis, thrombocytopenia, blood parasitism, and hepatopathy in a llama. J Am Vet Med Assoc 1994;204:213-215
5. Tornquist SJ, Van Saun RJ, Smith BB, et al Hepatic lipidosis in llamas and alpacas: 31 cases (1991-1997) J Am Vet Med Assoc 1999;214:1368-1372
6. Tornquist SJ, Cebra CK, van Saun RJ, et al Metabolic changes and induction of hepatic lipidosis during feed restriction in llamas. Am J Vet Res 2001;62:1081-1087.
7. Schumacher J, Spano JS, Wilson RC, et al Caffeine clearance in the horse. Vet Res Commun 1994;18:367-372.
8. Wasfi IA, Boni NS, Elghazali M, et al. The pharmacokinetics, metabolism and urinary detection time of caffeine in camels. Res Vet Sci 2000;69:69-74.
9. DeGraves FJ, Ruffin DC, Duran SH, et al. Pharmacokinetics of caffeine in lactating dairy cows. Am J Vet Res 1995;56:619-622.
10. Golden DL, Spano JS, Wilson RC, et al Application of an enzyme-multiplied immumoassay technique for determination of caffeine elimination kinetics as a test of liver function in clinically normal dogs. Am J Vet Res 1994;55:790-794.
11. Janus K, Antoszek J. The effect of sex and age on caffeine pharmacokinetics in cattle. Res Vet Sci 2000;69:33-37.
12. Janus K, Antoszek J, Suszycki S. The effect of short-term starvation or water deprivation on caffeine pharmacokinetics in calves. Res Vet Sci 2001;70:109-113.
13. Danielson TJ, Golsteyn LR. Systemic clearance and clemethylation of caffeine in sheep and cattle. Drug Metab Dispos 1996;24:1058-1061.
14. Holland DT, Godfredsen KA, Page T, et al Simple high-performance liquid chromatography method for the simultaneous determination of serum caffeine and paraxanthine following rapid sample preparation. J Chromatogr B Biomed Sci Appl 1998; 707:105-110.
15. Ermer J. Validation in pharmaceutical analysis Part I: an integrated approach. J Pharm Biomed Anal 2001;24:755-767.
16. Peck K, Mealey KL, Matthews NS, et al. In: Wernimont GT, Spendley W, eds. Use of statistics to develop and evaluate analytical methods. Gaithersburg, Md: AOAC International, 1985;11-30.
17. Akaike H. Information theory and an extension of the maximum likelihood principle, in Proceedings 2nd Int Symp Information Theory 1973;267-281.
18. Peck K, Mealey KL, Matthews NS, et al Comparative pharmacokinetics of caffeine and three metabolites in clinically normal horses and donkeys AmJ Vet Res 1997;58:881-884.
19. Jodynis-Liebert J, Flieger J, Matuszewska A, et al Serum metabolite/ caffeine ratios as a test for liver function. J Clin Pharmacol 2004;44:338-347
20. Boothe DM, Cullen JM, Calvin JA, et al Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease. Am J Vet Res 1994;55:254-261.
21. Greene EW, Woods WE, Tobin T Pharmacology, pharmacokinetics, and behavioral effects of caffeine in horses. Am J Vet Res 1983;44:57-63.
22. Chauret N, Gauthier A, Martin J, et al. In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse Drug Metab Dispos 1997;25:1130-1136.
23. Eberhardson B, Olsson G, Applegrew L, et al. Pharmacokinetic studies of phenylbutazone in cattle. J Vet Pharmacol Ther 1979;2:31-37
24. Williams RJ, Boudinot FD, Smith JA, et al. Pharmacokinetics of phenylbutazone in mature Holstein bulls: steady-state kinetics after multiple oral dosing. Am J Vet Res 1990;51:371-375
25. Williams RJ, Smith JA, Boudinot FD, et al. Pharmacokinetics of phenylbutazone given intravenously or orally in mature Holstein bulls. Am J Vet Res 1990;51:367-370.
26. Navarre CB, Ravis WR, Nagilla R, et al. Pharmacokinetics of phenylbutazone in llamas following single intravenous and oral doses. J Vet Pharmacol Ther 2001;24:227-231.
27. Cornelius CE. A review of new approaches to assessing hepatic function in animals. Vet Res Commun 1987;11:423-441.
28. Tennant B. Liver function In: Kaneko JJ, Harvey JW, Bruss ML, eds. Clinical biochemistry of domestic animals San Diego: Academic Press Inc, 1997;243-261.
29. Elsheikh HA, Osman IA, Abdullah AS. The effect of water deprivation on the pharmacokinetics of antipyrine and sulphadimidine following intravenous administration in nubian goats. Vet Res Commun 1997;21:587-597.
30. Janus K, Grochowina B, Antoszek J, et al. The effect of food or water deprivation on paracetamol pharmacokinetics in calves. J Vet Pharmacol Ther 2003;26:291-296.