Efficacy of S-carboxymethyl-L-cysteine for otitis media with effusion

Ear, Nose and Throat Journal

Volumn 85, Issue 5, 2006, Pages 296-297

  Steventon, G B ^a   Mitchell, S C ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOCISTEINE; DRUG DERIVATIVE; EXPECTORANT AGENT; S (2 CARBOXYETHYL)CYSTEINE; S-(2-CARBOXYETHYL)CYSTEINE; SULFOXIDE;

DOSAGE SCHEDULE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG METABOLISM; DRUG URINE LEVEL; HUMAN; LETTER; OTITIS MEDIA; OUTCOME ASSESSMENT; PHARMACODYNAMICS; SULFOXIDATION; METABOLISM; MIDDLE EAR; MUCOSA; SECRETORY OTITIS MEDIA; TREATMENT OUTCOME;

CARBOCYSTEINE; EAR, MIDDLE; EXPECTORANTS; HUMANS; MUCOUS MEMBRANE; OTITIS MEDIA WITH EFFUSION; SULFOXIDES; TREATMENT OUTCOME;

EID: 33745631001     PISSN: 01455613     EISSN: None     Source Type: Journal    
DOI: 10.1177/014556130608500502     Document Type: Letter

References (7)

1. Pignataro O, Pignataro LD, Gallus G, et al. Otitis media with effusion and S-carboxymethylcysteine and/or its lysine salt: A critical overview. Int J Pediatr Otorhinolaryngol 1996;35:231-41.
2. Mitchell SC, Waring RH, Haley CS, et al. Genetic aspects of the polymodally distributed sulphoxidation of S-carboxymethyl-L-cysteine in man. Br J Clin Pharmacol 1984;18:507-21.
3. Steventon GB. Diurnal variation in the metabolism of S-carboxymethyl-L- cysteine in humans. Drug Metab Dispos 1999;27: 1092-7.
4. Boonyapiwat B, Forbes B, Steventon GB. Phenylalanine hydroxylase: Possible involvement in the S-oxidation of S-carboxymethyl-1-cysteine. Anal Biochem 2004;335:91-7.
5. Goreish AH, Bednar S, Jones H, et al. Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine. Drug Metabol Drug Interact 2004;20:159-74.
6. Mitchell SC, Waring RH. The deficiency of sulfoxidation of S-carboxymethyl-L-cysteine. Pharmacol Ther 1989;43:237-49.
7. Brandolini L, Allegretti M, Berdini V, et al. Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs). Eur Cytokine Netw 2003;14:20-6.