Diurnal variation in the metabolism of S-carboxymethyl-L-cysteine in humans

Drug Metabolism and Disposition

Volumn 27, Issue 9, 1999, Pages 1092-1097

  Steventon, Glyn B ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOCISTEINE; GLYCOLIC ACID;

ACETYLATION; ADULT; ARTICLE; CHRONOBIOLOGY; CIRCADIAN RHYTHM; DEAMINATION; DECARBOXYLATION; DRUG EFFECT; DRUG METABOLISM; GLOMERULUS FILTRATION RATE; GLUCURONIDATION; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; SAMPLING; THIN LAYER CHROMATOGRAPHY;

ADULT; ANTI-INFECTIVE AGENTS, LOCAL; BIOTRANSFORMATION; CARBOCYSTEINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCADIAN RHYTHM; HUMANS; MALE; OXIDATION-REDUCTION;

GLOMERULUS;

EID: 0032841648     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Ayesh R, Mitchell SC, Waring RH and Smith RL (1988) Taste sensitivity to phenylthiourea: Lack of correlation with debrisoquine and carboxymethylcysteine oxidation polymorphisms. Br J Clin Pharmacol 25:664P.
2. Ayesh R, Mitchell SC, Waring RH, Withrington RH, Seifert MH and Smith RL (1987) Sodium aurothiomalate toxicity and sulphoxidation capacity in rheumatoid arthritis patients. Br J Rheumatol 26:197-201.
3. Berk Pharmaceuticals Limited (1973) Monograph on S-carboxymetkylcysteine, pp 19, Guildford, Surrey, England.
4. Binkley F (1950) Enzymatic cleavage of thioethers. J Biol Chem 182:273.
5. Blood FR and Lewis HB (1941) The metabolism of sulfur, XXIX. S-carboxymethylcysteine. J Biol Chem 139:407-412.
6. Bradley H, Gough A, Sokhi RS, Hassell A, Waring R and Emery P (1994) Sulfate metabolism is abnormal in patients with rheumatoid arthritis. Confirmation by in vivo biochemical findings. J Rheumatol 21:1192-1196.
7. Brand E, Block RJ, Kassell B and Cahill GF (1936) Carboxymethylcysteine metabolism, its implication on therapy in cystinuria and on methionine-cysteine relationship. Proc Soc Exp Biol Med 35:501-503.
8. Brockmoller J, Staffedlt B and Roots I (1991) Evaluation of proposed sulphoxidation pathways of carbocysteine in man by HPLC quantification. Ear J Clin Pharmacol 40:387-392.
9. Emery P, Panayi GS, Huston G, Welsh KI, Mitchell SC, Shah RR, Idle JR, Smith RL and Waring RH (1984) D-penicillamine induced toxicity in rheumatoid arthritis: Role of sulphoxidation status and HLA-DR3. J Rheumatol 11:626-632.
10. Gregory WL, James OFW, Turner I, Meese CO and Idle JR (1993) Re-evaluation of the metabolism of carbocisteine in a British white population. Pharmacogenetics 3:270-274.
11. Haley CS, Waring RH, Mitchell SC, Shah RR, Idle JR and Smith RL (1985) Lack of congruence of S-carboxymethyl-L-cysteine sulphoxidation and debrisoquine 4-hydroxylation in a Caucasian population. Xenobiotica 15:445-450.
12. Hofmann U, Eichelbaum M, Seefried S and Meese CO (1991) Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine. Drug Metab Dispos 19:222-226.
13. Kupfer A. Gerber F, Manser E, Turner I, Idle JR (1991) Revised protocol for carbocysteine phenotyping in man (Abstract R10). Naunyn-Schmiedeberg's Arch Pharmacol 343:38.
14. Kupfer A and Idle JR (1990) False positives with current carbocysteine protocol for sulphoxidation phenotyping. Lancet 335:1107.
15. Labreque G and Belanger PM (1991) Biological rhythms in absorption, distribution, metabolism and excretion of drugs. Pharmacol Ther 52:95-107.
16. Meese CO (1987) S-carboxymethyl-L-cystein-(R)-und (S)-sulfoxid. Arch Pharm (Weinheim) 320:473-474.
17. Meese CO, Fischer C. Kupfer A. Wisser H and Eichelbaum M (1991) Identification of the "major" polymorphic carbocysteine metabolite as S-(carboxymethylthio)-L-cysteine. Biochem Pharmacol 42:R13-R16.
18. 13C) analogues. Arch Pharm (Weinheim) 323:957-965.
19. Mitchell SC and Waring RH (1989) The deficiency of sulphoxidalion of S-carboxymethyl-L-cysteine. Pharmacol Ther 43:237-249.
20. Mitchell SC, Waring RH, Haley CS, Idle JR and Smith RL (1984) Genetic aspects of the polymodally distributed sulphoxidation of S-carboxymethyl-L-cysteine in man. Br J Clin Pharmacol 18:507-521.
21. Mitchell SC. Waring RH and Steventon GB (1992) Variation in the S-oxidation of cysteine derivatives, in Pharmacogenetics of Drug Metabolism (Kalow W ed) pp 367-382, Pergamon Press, New York.
22. Olomu AB, Vickers CR, Waring RH, Clements D, Babbs C, Warnes CW and Ellas E (1988) High incidence of poor sulphoxidation in patients with primary biliary cirrhosis. New Engl J Med 318:1089-1092.
23. Price-Evans D (1993) Genetic Factors in Drug Therapy: Clinical and Molecular Phamacogenetics, pp 371, Cambridge University Press, Cambridge.
24. Scadding GK, Ayesh R, Brostoff J, Mitchell SC, Waring RH and Smith RL (1988) Poor sulphoxidation ability in patients with food sensitivity. Br Med J 297:105-107.
25. Schober A and Grafje H (1958) Aminocarbonsauren und haarkeratin mit unsymmetrisch eingebauten disulfidbindungen. Ein beitrag zu dem problem des disulfidaustausches. Liebigs Ann Chem 617:71-88.
26. Specht D, Meese CO, Ratge D, Eichelbaum E and Wisser H (1990) The metabolic pattern of S-carboxymethyl-L-cysteine. A new study with HPLC and a novel ex vivo carbon-13-NMR-method. Fresenius J Anal Chem 337:63-64.
27. Staffeldt B, Brockmoller J and Roots 1 (1991) Determination of S-carboxymethyl-L-cysteine and some of its metabolites in urine and serum by high-performance liquid chromatography using fluorescent pre-column labelling. J Chromatogr 571:133-147.
28. Steventon GB (1998) A methodological and metabolite identification study of the metabolism of S-carboxymethyl-L-cysteine. Chromatographia 48:561-568.
29. Steventon G, Waring R, Sturman S, Heafield M and Williams A (1999) The metabolism of S-carboxymethyl-L-cysteine in man. A neurodegenerative disease study. Med Sci Res 27:119-120.
30. Waring RH (1980) Variation in human metabolism of S-carboxymethylcysteine. Eur J Drug Metab Pharmacokinet 5:49-52.
31. Waring RH and Mitchell SC (1990) Carbocysteine sulphoxidation phenotype. Lancer 335:1527.
32. Waterhouse JM and Minors DS (1989) Temporal aspects of renal drug elimination, in Chronophamacology: Cellular and Biochemical Interactions (Lemmer B ed) pp 35-50, Marcel Dekker Inc. New York.