Biological exposure indicators: Quantification of biological variability using toxicokinetic modeling

Journal of Occupational and Environmental Hygiene

Volumn 3, Issue 3, 2006, Pages 137-143

  Truchon, Ginette ^a   Tardif, Robert ^b   Droz, Pierre Olivier ^c   Charest Tardif, Ginette ^b   Pierrehumbert, Guillaume ^c  

^a INSTITUT DE RECHERCHE ROBERT SAUVÉ EN SANTÉ ET EN SÉCURITÉ DU TRAVAIL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Biological monitoring; Human variability; Toxicokinetic modeling

Indexed keywords

HEAVY METAL; ORGANIC COMPOUND;

AIR POLLUTANT; ARTICLE; BIOLOGICAL MODEL; ENVIRONMENTAL MONITORING; HUMAN; METHODOLOGY; MONTE CARLO METHOD; OCCUPATIONAL EXPOSURE;

AIR POLLUTANTS, OCCUPATIONAL; ENVIRONMENTAL MONITORING; HUMANS; METALS, HEAVY; MODELS, BIOLOGICAL; MONTE CARLO METHOD; OCCUPATIONAL EXPOSURE; ORGANIC CHEMICALS;

EID: 33745625411     PISSN: 15459624     EISSN: 15459632     Source Type: Journal    
DOI: 10.1080/15459620500524987     Document Type: Article

References (21)

1. Lauwerys, R.R., and P. Hoet: Industrial Chemical Exposure, 3rd edition, London, Lewis, 2001.
2. Löf, A., and G. Johanson: Toxicokinetics of organic solvents: A review of modifying factors. Crit. Rev. Toxicol. 28:571-650 (1998).
3. Thomas, R.S., W.A. Lytle, T.J. Keefe, A.A. Constan, and R.S. Yang: Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using advanced continuous simulation language (ACSL): A computational method. Fundam. Appl. Toxicol. 3:19-28 (1996).
4. Thomas, R.S., P.L. Bigelow, T.J. Keefe, and R.S. Yang: Variability in biological exposure indices using physiologically based pharmacokinetic modeling and Monte Carlo simulation. Am. Ind. Hyg. Assoc. J. 57:23-32 (1996).
5. 8-toluene toxicokinetic assessed by a semiempirical physiologically based model. Toxicol. Appl. Pharmacol. 139:49-61 (1996).
6. Jang, J.Y., P.O. Droz, and M. Berode: Ethnic differences in biological monitoring of several organic solvents. I. Human exposure experiment. Int. Arch. Occup. Environ. Health 69:343-349 (1997).
7. Simon, T.W.: Combining physiologically based pharmacokinetic modeling with Monte Carlo simulation to derive an acute inhalation guidance value for trichloroethylene. Reg. Toxicol. Pharmacol. 26:257-270 (1997).
8. Sweeney, M.L., T.R. Tyler, C.R. Kirman, et al.: Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulation. Toxicol. Sci. 62:124-139 (2001).
9. Ramsey, J.C., and M.E. Andersen: A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73:159-175 (1984).
10. Tardif, R., P.O. Droz, G. Charest-Tardif, G. Pierrehumbert, and G. Truchon: Impact of human variability on the biological monitoring of exposure to toluene: I. Physiologically based toxicokinetic modelling. Toxicol. Lett. 134:155-163 (2002).
11. Pierrehumbert, G., P.O. Droz, R. Tardif, G. Charest-Tardif, and G. Truchon: Impact of human variability on the biological monitoring of exposure to toluene: II. Compartmental based toxicokinetic modelling. Toxicol. Lett. 134:165-175 (2002).
12. Portier, C.J., and N.L. Kaplan: Variability of safe dose estimates when using complicated models of the carcinogenic process: A case study: Methylene chloride. Fundam. Appl. Toxicol. 13:533-544 (1989).
13. Evans, M.V., and M.E. Andersen: Sensitivity analysis and the design of gas uptake inhalation studies. Inhalation Toxicol. 7:1075-1074 (1995).
14. American Conference of Governmental Industrial Hygienists (ACGIH®R): TLV®Rs and BEI®Rs. Cincinnati, Ohio: ACGIH, 2004.
15. Astrand, L.: Effect of physical exercise on uptake, distribution and elimination of vapors in man. In the Modeling of Inhalation Exposure to Vapors: Uptake, Distribution and Elimination, Vol. 2, V. Fiserove-Bergerova (ed.). Boca Raton, Fla.: CRC Press, 1983. p. 107.
16. Pezzagno, G., M. Imbriani, S. Ghittori, and E. Capodaglio: Urinary concentration, environmental concentration and respiratory uptake of some solvents: Effect of workload. Am. Ind. Hyg. Assoc. J. 49:546-552 (1988).
17. Berget, K.L., and K. Nestler: Solvent uptake in relation to physical activity. Sci. Total Environ. 101:111 (1991).
18. Laparé, S., R. Tardif, and J. Brodeur: Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air. II. 1,1,1-trichloroethane and trichloroethylene. Int. Arch. Occup. Environ. Health 67:375-394 (1995).
19. Nadeau, V., G. Truchon, M. Brochu, and R. Tardif: Effect of physical exertion on the biological exposure indices of various solvents following exposure by inhalation in human volunteers: 1. Toluene. J. Occup. Environ. Health (Submitted).
20. Tardif, R., G. Truchon, and J. Brodeur: Comparison of hippuric acid and o-cresol in urine and unchanged toluene in alveolar air for the biological monitoring of exposure to toluene in human volunteers. Appl. Occup. Environ. Health 13:127 (1998).
21. Hattis, D., and K. Silver: Human interindividual variability - A major source of uncertainty in assessing risks for noncancer health effects. Risk Anal. 14:421-431 (1994).