Phosphodiesterase 4 inhibitor rolipram potentiates the inhibitory effect of calcitonin on osteoclastogenesis

Journal of Bone and Mineral Metabolism

Volumn 24, Issue 4, 2006, Pages 260-265

  Miyamoto, Ken Ichi ^a   Nishioka, Tatsuo ^a   Waki, Yoshihiro ^b   Nomura, Masaaki ^a,c   Katsuta, Hiromu ^d   Yokogawa, Koichi ^a   Amano, Hitoshi ^e  

^a KANAZAWA UNIVERSITY   (Japan)

^b NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^c HOKURIKU UNIVERSITY   (Japan)

^d Examination Research Section   (Japan)

^e SHOWA UNIVERSITY   (Japan)

Author keywords

Bone marrow cells; Calcitonin; Osteoclastogenesis; Phosphodiesterase 4; Rolipram

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CALCITONIN; CALCITONIN RECEPTOR; COLONY STIMULATING FACTOR 1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL ADHESION; CELL MATURATION; CONTROLLED STUDY; DRUG INHIBITION; FEMUR; HYDROLYSIS; MALE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TIBIA;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; CALCITONIN; DRUG SYNERGISM; ENZYME INHIBITORS; MICE; OSTEOCLASTS; RNA, MESSENGER; ROLIPRAM;

EID: 33745619221     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-006-0682-3     Document Type: Article

References (28)

1. 2, calcitonin, and 1,25- dihydroxycholecalciferol Endocrinology 107 1474 1481
2. JA Beavo 1995 Cyclic nucleotide phosphodiesterases; functional implications of multiple isoforms Physiol Rev 75 725 748
3. M Conti G Nemoz C Sette E Vicini 1995 Recent progress in understanding the hormonal regulation of phosphodiesterases Endocrine Rev 16 370 389
4. SH Soderling SJ Bayuga JA Beavo 1998 Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase Proc Natl Acad Sci USA 95 8991 8996
5. DA Fisher JF Smith JS Pillar SH St. Denis JB Cheng 1998 Isolation and characterization of PDE 9A, a novel human cGMP-specific phosphodiesterase J Biol Chem 273 15559 15564
6. JB Polson JJ Krzanowski A Szentivanyi 1982 Inhibition of high affinity cyclic AMP phosphodiesterase and relaxation of canine tracheal smooth muscle Biochem Pharmacol 31 3404 3406
7. K Miyamoto M Kurita S Ohmae R Sakai F Sanae K Takagi 1994 Selective tracheal relaxation and phosphodiesterase-IV inhibition by xanthine derivatives Eur J Pharmacol 267 317 322
8. J Semmler H Wachtel S Endres 1993 The specific type IV phosphodiesterase inhibitor rolipram suppress TNFα production by human mononuclear cells Int J Immunopharmacol 15 409 413
9. K Miyamoto Y Waki T Horita S Kasugai K Ohya 1997 Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4 Biochem Pharmacol 54 613 617
10. Y Waki T Horita K Miyamoto K Ohya S Kasugai 1999 Effects of XT-44, a phosphodiesterase 4 inhibitor, in osteoblastogenesis and osteoclastogenesis in culture and its therapeutic effects in rat osteopenia models Jpn J Pharmacol 79 477 483
11. 2-mediated anabolic effect of a novel inhibitor of phosphodiesterase 4, XT-611, in the in vitro bone marrow culture J Bone Miner Res 18 1471 1477
12. 2 Biochem Pharmacol 66 801 807
13. DM Anderson E Maraskovsky WL Billingsley WC Dougall ME Tometsko ER Roux MC Teepe RF Dubose D Cosman L Galibert 1997 A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function Nature (Lond) 390 175 179
14. H Yasuda N Shima N Nakagawa K Yamaguchi M Kinosaki S Mochizuki A Tomoyasu K Yano M Goto A Murakami E Tsuda T Morinaga K Higashio N Udagawa N Takahashi T Suda 1998 Osteoclast differentation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and its identical to TRANCE/RANKL Proc Natl Acad Sci USA 95 3597 3602
15. NJ Horwood J Elliott TJ Martin MT Gillespie 1998 Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells Endocrinology 139 4743 4746
16. M Nagai N Sato 1999 Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation Biochem Biophys Res Commun 257 719 723
17. K Hata T Kukita A Akamine A Kukita K Kurisu 1992 Trypsinized osteoclast-like multinucleated cells formed in rat bone marrow cultures efficiently form resorption lacunae on dentine Bone (NY) 13 139 146
18. 2 directly inhibits bone-resorbing activity of isolated mature osteoclasts mainly through EP4 receptor Calcif Tissue Int 67 85 92
19. N Takahashi H Yamana S Yoshiki GD Roodman GR Mundy SJ Jones A Boyde T Suda 1988 Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cutures Endocrinology 122 1373 1382
20. IA Ly RI Mishell 1974 Separation of mouse spleen cells by passage through column of Sephadex G-10 J Immunol Methods 5 239 247
21. S Niida M Kaku H Amano H Yoshida H Kataoka S Nishikawa K Tanne N Maeda S Nishikawa H Kodama 1999 Vascular endotherial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption J Exp Med 190 293 298
22. K Matsuo DL Galson C Zhao L Peng C Laplace KZ Wang MA Bachler H Amano H Aburatani H Ishikawa EF Wagner 2004 Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos J Biol Chem 279 26475 26480
23. H Amano S Yamada R Felix 1998 Colony-stimulating factor-1 stimulates the fusion process in osteoclasts J Bone Miner Res 13 846 853
24. Y Waki K Miyamoto S Kasugai K Ohya 1995 Osteoporosis-like changes in Walker carcinoma 256-bearing rats, not accompanied with hypercalcemia or parathyroid hormone-related protein production Jpn J Cancer Res 86 470 476
25. AH Gorn SM Rudolph MR Flannery CC Morton S Weremowicz TZ Wang SM Krane SR Goldring 1995 Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction J Clin Invest 95 2680 2691
26. S Wada N Udagawa T Akatsu N Nagata TJ Martin DM Findlay 1997 Regulation by calcitonin and glucocorticoids of calcitonin receptor gene expression in mouse osteoclasts Endocrinology 138 521 529
27. BJ Lipworth 2005 Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease Lancet 365 167 175
28. 3H]rolipram binding activity and their relationship to emetic behavior in the ferret J Med Chem 39 120 125