c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization

EMBO Reports

Volumn 7, Issue 7, 2006, Pages 727-733

  di Bari, Maria Giovanna ^a   Ciuffini, Laura ^b   Mingardi, Michele ^a,c   Testi, Roberto ^a   Soddu, Silvia ^b   Barilà, Daniela ^a,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Acetylation; cAbl; Myogenic differentiation; p300; Subcellular localization

Indexed keywords

ABELSON KINASE; HISTONE ACETYLTRANSFERASE; LYSINE DERIVATIVE;

ACETYLATION; ARTICLE; BIOACCUMULATION; CELL DIFFERENTIATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; MODULATION; MUSCLE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN PROCESSING; REGULATORY MECHANISM;

ACETYLATION; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; CYTOPLASM; HISTONE ACETYLTRANSFERASES; HUMANS; LYSINE; MICE; MOLECULAR SEQUENCE DATA; MUSCLE DEVELOPMENT; NUCLEAR LOCALIZATION SIGNALS; P300-CBP TRANSCRIPTION FACTORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-ABL; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 33745594612     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400700     Document Type: Article

References (30)

1. Bannister AJ, Miska EA, Gorlich D, Kouzarides T (2000) Acetylation of importin-α nuclear import factors by CBP/p300. Curr Biol 10: 467-470
2. Barilà D, Superti-Furga G (1998) An intramolecular SH3 interaction regulates c-Abl activity. Nat Genet 18: 280-282
3. Barilà D, Rufini A, Condò I, Ventura N, Dorey K, Superti-Furga G, Testi R (2003) Caspase-dependent cleavage of c-Abl contributes to apoptosis. Mol Cell Biol 23: 2790-2799
4. Bonaldi T, Talamo F, Scaffidi P, Ferrera D, Porto A, Bachi A, Rubartelli A, Agresti A, Bianchi ME (2003) Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 22: 5551-5560
5. Conti E, Uy M, Leighton L, Blobel G, Kuriyan J (1998) Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin α. Cell 94: 193-204
6. Dan S, Naito M, Seimiya H, Kizaki A, Mashima T, Tsuruo T (1999) Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells. Oncogene 18: 1277-1283
7. Furstoss O, Dorey K, Simon V, Barilà D, Superti-Furga G, Roche R (2002) c-Abl is a downstream effector of the Src family tyrosine kinases for growth factor-induced c-myc expression and DNA synthesis. EMBO J 21: 514-524
8. Gay F, Calvo D, Lo MC, Ceron J, Maduro M, Lin R, Shi Y (2003) Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1. Genes Dev 17: 717-722
9. Gu W, Roeder RG (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90: 595-606
10. Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G (2003) A myristoyl/phosphotyrosine switch regulates c-Abl. Cell 112: 845-857
11. Iezzi S, Cossu G, Nervi C, Sartorelli V, Puri PL (2002) Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. Proc Natl Acad Sci USA 99: 7757-7762
12. Lewis JM, Baskaran R, Taagepera S, Schwartz MA, Wang JY (1996) Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc Natl Acad Sci USA 93: 15174-15179
13. Madison DL, Yaciuk P, Kwok RP, Lundblad JR (2002) Acetylation of the adenovirus-transforming protein E1A determines nuclear localization by disrupting association with importin-α. J Biol Chem 277: 38755-38763
14. McKinsey TA, Zhang CL, Olson EN (2001) Control of muscle development by dueling HATs and HDACs. Curr Opin Genet Dev 11: 497-504
15. Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J (2003) Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell 112: 859-871
16. Pendergast AM (2002) The Abl family kinases: Mechanisms of regulation and signaling. Adv Cancer Res 85: 51-100
17. Plattner R, Kadlec L, DeMali KA, Kazlauskas A, Pendergast AM (1999) c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev 13: 2400-2411
18. Pluk H, Dorey K, Superti-Furga G (2002) Autoinhibition of c-Abl. Cell 108: 246-259
19. Polesskaya A, Naguibneva I, Fritsch L, Duquet A, Ait-Si-Ali S, Robin P, Vervisch A, Pritchard LL, Cole P, Harel-Bellan A (2001) CBP/p300 and muscle differentiation: No HAT, no muscle. EMBO J 20: 6816-6825
20. Poon IK, Jans DA (2005) Regulation of nuclear transport: Central role in development and transformation? Traffic 6: 173-186
21. Puri PL, Bhakta K, Wood LD, Costanzo A, Zhu J, Wang JY (2002) A myogenic differentiation checkpoint activated by genotoxic stress. Nat Genet 32: 585-593
22. Santos-Rosa H, Valls E, Kouzarides T, Martinez-Balbas M (2003) Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res 31: 4285-4292
23. Soutoglou E, Katrakili N, Talianidis I (2000) Acetylation regulates transcription factor activity at multiple levels. Mol Cell 5: 745-751
24. Spilianakis C, Papamatheakis J, Kretsovali A (2000) Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Mol Cell Biol 20: 8489-8498
25. Taagepera S, McDonald D, Loeb JE, Whitaker LL, McElroy AK, Wang JYJ, Hope TJ (1998) Nuclear-cytoplasmic shuttling of c-Abl tyrosine kinase. Proc Natl Acad Sci USA 95: 7457-7462
26. Wang JY (2005) Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress. Cell Res 15: 43-48
27. Wen ST, Jackson PK, Van Etten RA (1996) The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J 15: 1583-1595
28. Yang XJ (2004) Lysine acetylation and the bromodomain: A new partnership for signaling. BioEssays 26: 1076-1087
29. Yoshida K, Yamaguchi T, Natsume T, Kufe D, Miki Y (2005) JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol 7: 278-285
30. Yuan ZM, Huang Y, Ishiko T, Kharbanda S, Weichselbaum R, Kufe D (1997) Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci USA 94: 1437-1440