Topical application versus intranasal instillation: A qualitative comparison of the effect of the route of sensitization on trimellitic anhydride-induced allergic rhinitis in A/J mice

Toxicological Sciences

Volumn 92, Issue 1, 2006, Pages 321-328

  Farraj, Aimen K ^a,c   Harkema, Jack R ^b   Kaminski, Norbert E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c US Enviromental Protection Agency   (United States)

Author keywords

A J mice; Allergic rhinitis; Intranasal instillation; Route of exposure; Topical application; Trimellitic anhydride

Indexed keywords

ACETIC ACID ETHYL ESTER; ALLERGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; OLIVE OIL; TRIMELLITIC ANHYDRIDE;

ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ADMINISTRATION ROUTE; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE; MALE; MOUSE; NONHUMAN; NOSE OBSTRUCTION; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIZATION; TOXICITY TESTING;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, TOPICAL; ANHYDRIDES; ANIMALS; CYTOKINES; EAR; GENE EXPRESSION; IMMUNOGLOBULIN E; MICE; NASAL MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHINITIS; TRACHEA;

MURINAE;

EID: 33745593443     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj191     Document Type: Article

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