MIB-1 labelling indices according to clinico-pathological variables in canine mammary tumours: A multivariate study

Anticancer Research

Volumn 26, Issue 3 A, 2006, Pages 1821-1826

  Ferreira De Matos, Augusto José ^a   Carreiras Lopes, Célia Cristina ^a   Rodrigues Faustino, Augusto Manuel ^a   Vale Carvalheira, Júlio Gil ^a   Amaro Dos Santos, Marta Susana ^a   Rutteman, Gerard Röels ^b   Rodrigues Moutinho Gärtner, Maria De Fátima ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Dog; Mammary tumours; MIB 1

Indexed keywords

GESTAGEN; KI 67 ANTIGEN; UVOMORULIN;

AGE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; BREED; CELL PROLIFERATION; CONTROLLED STUDY; DOG; FEMALE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LABELING INDEX; LYMPH NODE METASTASIS; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NONHUMAN; PREGNANCY RATE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR NECROSIS; TUMOR VOLUME;

ANIMALS; DOG DISEASES; DOGS; FEMALE; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LOGISTIC MODELS; LYMPHATIC METASTASIS; MAMMARY NEOPLASMS, ANIMAL; MULTIVARIATE ANALYSIS; NEOPLASM STAGING;

EID: 33745591138     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Misdorp W, Else RW, Hellmén E and Lipscomb TP: Histological Classification of Mammary Tumors of the Dog and the Cat. World Health Organization Histological Classification of Tumors of Domestic Animals, second series, vol. 7, no. 2. Armed Forces Institute of Pathology, Washington, D.C., 1999.
2. Durchow M, Gerdes J and Schluter C: The proliferation-associated Ki-67 protein: definition in molecular terms. Cell Prolif 27: 235-242, 1994.
3. Cattoretti G, Becker MHG, Key G, Duchrow M, Schluter C, Galle J and Gerdes J: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168: 357-363, 1992.
4. McCormick D, Chong H, Hobbs C, Datta C and Hall PA: Detection of Ki-67 antigen in fixed and wax embedded sections with the monoclonal antibody MIB1. Histopathology 22: 355-360, 1993.
5. Benini E, Rao S, Grazia Daidone M, Pilotti S and Silvestrini R: Immunoreactivity to MIB-1 in breast cancer: methodological assessment and comparison with other proliferation indices. Cell Proliferat 30: 107-115, 1997.
6. Zacchetti A, Van Garderen E, Teske E, Nederbragt H, Dierendonck JH and Rutteman GR: Validation of the use of proliferation markers in canine neoplastic and non-neoplastic tissues: comparison of KI-67 and proliferating cell nuclear antigen (PCNA) expression versus in vivo bromodeoxuridine labelling by immunohistochemistry. APMIS 111: 430-438, 2003.
7. Nieto A, Peña L, Pérez-Alenza MD, Sánchez MA, Flores JM and Castaño M: Immunohistologic detection of estrogen receptor alpha in canine mammary tumors: clinical and pathologic associations and prognostic significance. Vet Pathol 37: 239-247, 2000.
8. Peña L, Nieto A, Pérez-Alenza MD, Cuesta P and Castaño M: Immunohistochemical detection of Ki-67 and PCNA in canine mammary tumors: relationship to clinical and pathologic variables. J Vet Diagn Invest 10: 237-246, 1998.
9. Sarli G, Preziosi R, Benazzi C, Castellani G and Marcato PS: Prognostic value of histologic stage and proliferative activity in canine malignant mammary tumors. J Vet Diagn Invest 14: 25-34, 2002.
10. Löhr CV, Teifke JP, Failing K and Weiss E: Characterization of the proliferation state in canine mammary tumors by the standardized AgNOR method with postfixation and immunohisto-logic detection of Ki-67 and PCNA. Vet Pathol 34: 212-221, 1997.
11. Madewell BR: Cellular proliferation in tumors: a review of methods, interpretation, and clinical applications. J Vet Intern Med 15: 334-340, 2001.
12. Matos AJF, Faustino AMR, Lopes C, Rutteman GR and Gärtner F: Detection of lymph node micrometastasis in canine malignant mammary tumours with the use of cytokeratin immunostaining. Vet Rec, in press, 2006.
13. Rutteman GR, Withrow SJ and MacEwen EG: Tumors of the mammary gland. In: Small Animal Clinical Oncology, 3rd ed. Withrow SJ, MacEwen EG (eds.). W. B. Saunders Company, pp. 455-477, 2001.
14. Elston CW and Ellis IO: Assessment of histological grade. In: Rosen's Breast Pathology. Rosen PP (ed.). Lippincott-Raven Publ., Philadelphia, pp. 365-382, 1998.
15. Hsu SM, Faine L and Fanger H: A comparative study of the peroxidase-antiperoxidase method and the avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. Am J Clin Pathol 75: 734-738, 1981.
16. Matos AJF, Lopes C, Carvalheira J, Santos M, Rutteman GR and Gärtner F: E-cadherin expression in canine malignant mammary tumours: relationship to other clinico-pathological variables. J Comp Pathol, in press, 2006.
17. SAS Institute Inc. SAS/STAT® User's Guide, Version 6, Fourth Edition, Cary, NC: SAS Institute Inc., pp. 943, 1989.
18. Connor AJM, Finder SE, Elston CW, Bell JA, Wencyk P, Robertson JFR, Blarney RW, Nicholson RI and Ellis IO: Intratumoural heterogeneity of proliferation in invasive breast carcinoma evaluated with MIB1 antibody. The Breast 6: 171-176, 1997.
19. Geraldes M, Gärtner F and Schmitt F: Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mammary glands and spontaneous mammary tumours. Vet Rec 146: 403-406, 2000.
20. Castagnaro M, DeMaria R, Bozzetta E, Ru G, Casalone C and Caramelli M: Ki-67 index as indicator of the post-surgical prognosis in feline mammary carcinomas. Res Vet Sci 65: 223-226, 1998.
21. Dias Pereira P, Carvalheira J and Gärtner F: Cell proliferation in feline normal, hyperplastic and neoplastic mammary tissue - an immunohistochemical study. Vet J 168: 180-185, 2004.
22. Yamagami T, Kobayashi T, Takahashi K and Sugiyama M: Prognosis for canine malignant tumors based on TNM and histologic classification. J Vet Med Sci 58: 1079-1083, 1996.
23. Pérez-Alenza MD, Peña L, Nieto AI and Castaño M: Clinical and pathological prognostic factors in canine mammary tumors. Ann Inst Sup San 33: 581-585, 1997.
24. Philibert JC, Snyder PW, Glickman N, Glickman LT, Knapp DW and Waters DJ: Influence of host factors on survival in dogs with malignant mammary gland tumors. J Vet Intern Med 17: 102-106, 2003.
25. Schmitt FC and Ferreira MP: MIB-1 is a suitable marker of proliferative activity in formalin-fixed, paraffin-embedded sections of breast cancer. Int J Surg Pathol 2: 287-294, 1995.
26. Barnard NJ, Hall PA, Lemoine NR and Kadar N: Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables. J Pathol 152: 287-295, 1987.
27. Isola JJ, Helin HJ, Helle MJ and Kallioniemi OP: Evaluation of cell proliferation in breast carcinoma. Comparison of Ki-67 immunohistochemical study, DNA flow cytometric analysis, and mitotic count. Cancer 65: 1180-1184, 1990.
28. Leonardi E, Girlando S, Serio G, Mauri FA, Perone G, Scampini S, Dalla Palma P and Barbareschi M: PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables. J Clin Pathol 45: 416-419, 1992.
29. Hyder SM, Chiappetta C and Stancel GM: Pharmacological and endogenous progestins induce vascular endothelial growth factor expression in human breast cancer cells. Int J Cancer 92: 469-473, 2001.
30. Wu J, Richer J, Horwitz KB and Hyder SM: Progestin-dependent induction of vascular endothelial growth factor in human breast cancer cells: preferential regulation by progesterone receptor B. Cancer Res 64: 2238-2244, 2004.
31. Kurebayashi J, Kunisue H, Yamamoto S, Kurosumi M, Otsuki T and Sonoo H: Paradoxical hormone responses of KPL-1 breast cancer cells in vivo: a significant role of angiogenesis in tumour growth. Oncology 59: 158-165, 2000.
32. Veronese SM and Gambacorta M: Detection of Ki-67 proliferation rate in breast cancer. Correlation with clinical and pathological features. Am J Clin Pathol 95: 30-34, 1991.
33. Hellmén E, Bergström R, Holmberg L, Spångberg I-B, Hansson K and Lindgren A: Prognostic factors in canine mammary tumors: a multivariate study of 202 consecutive cases. Vet Pathol 30: 20-27, 1993.
34. Shofer FS, Sonnenschein EG, Goldschmidt MH, Laster LL and Glickman LT: Histopathologic and dietary prognostic factors for canine mammary carcinoma. Breast Cancer Res Treat 13: 49-60, 1989.