Cu(OTf)2 or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of α-aminonitriles

Tetrahedron Letters

Volumn 47, Issue 32, 2006, Pages 5759-5762

  Paraskar, Abhimanyu S ^a   Sudalai, Arumugam ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Aldehydes; Aminonitriles; Multicomponent reactions; Organocatalyst; Strecker reaction

Indexed keywords

ALDEHYDE DERIVATIVE; ALPHA AMINONITRILE DERIVATIVE; AMINE; COPPER DERIVATIVE; CYANIDE; CYANOHYDRIN; IMINE; NITRILE; TRIMETHYLSILYL CYANIDE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; CATALYSIS; CATALYST; ENVIRONMENTAL TEMPERATURE; POLYMERIZATION; SYNTHESIS;

EID: 33745590830     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.06.008     Document Type: Article

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32. 3N (0.1 mmol) in acetonitrile (10 mL) was stirred at 25 °C and was monitored by TLC. After completion of the reaction, it was extracted with ethyl acetate (20 mL) and washed with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product, which was purified by column chromatography on silica gel using 15% ethyl acetate in petroleum ether as eluent to afford the pure product.
33. 2 calcd C, 75.75; H, 8.48; N, 7.36; found C, 75.83; H, 8.50; N, 7.27.