Expression of an expanded polyglutamine domain in yeast causes death with apoptotic markers

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1757, Issue 5-6, 2006, Pages 660-666

  Sokolov, Sviatoslav ^a   Pozniakovsky, Andrey ^b   Bocharova, Natalia ^a   Knorre, Dmitry ^a   Severin, Fedor ^c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Apoptosis; Huntingtin; Mitochondria; Polyglutamine; Yeast

Indexed keywords

ALPHA TOCOPHEROL; CASPASE; CELL NUCLEUS DNA; DNA FRAGMENT; POLYGLUTAMINE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; MITOCHONDRION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; YEAST CELL;

ALPHA-TOCOPHEROL; ANTIOXIDANTS; APOPTOSIS; BIOLOGICAL MARKERS; CASPASES; CELL CYCLE; CELL NUCLEUS; DNA, FUNGAL; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 33745586752     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2006.05.004     Document Type: Article

References (35)

1. Breitenbach M., Madeo F., Laun P., Heeren G., Jarolim S., Frohlich K.U., Wissing S., and Pichova A. Yeast as a model for ageing and apoptosis research. Topics in Current Genetics vol. 3 (2003), Springer-Verlag, Berlin-Heidelberg 61-97
2. Longo V.D., Mitteldorf J., and Skulachev V.P. Opinion: programmed and altruistic ageing. Nat. Rev., Genet. 6 (2005) 866-872
3. Chen Q., Ding Q., and Keller J.N. The stationary phase model of aging in yeast for the study of oxidative stress and age-related neurodegeneration. Biogerontology 6 (2005) 1-13
4. Herker E., Jungwirth H., Lehmann K.A., Maldener C., Frohlich K.U., Wissing S., Buttner S., Fehr M., Sigrist S., and Madeo F. Chronological aging leads to apoptosis in yeast. J. Cell Biol. 164 (2004) 501-507
5. Fabrizio P., Battistella L., Vardavas R., Gattazzo C., Liou L.L., Diaspro A., Dossen J.W., Gralla E.B., and Longo V.D. Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J. Cell Biol. 166 (2004) 1055-1067
6. Ludovico P., Madeo F., and Silva M. Yeast programmed cell death: an intricate puzzle. IUBMB Life 57 (2005) 129-135
7. Outeiro T.F., and Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302 (2003) 1772-1775
8. Griffioen G., Duhamel H., Van Damme N., Pellens K., Zabrocki P., Pannecouque C., van Leuven F., Winderickx J., and Wera S. A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential. Biochim. Biophys. Acta, Mol. Basis Dis. 1762 (2006) 312-318
9. Shimohama S., Sawada H., Kitamura Y., and Taniguchi T. Disease model: Parkinson's disease. Trends Mol. Med. 9 (2003) 360-365
10. Flower T.R., Chesnokova L.S., Froelich C.A., Dixon C., and Witt S.N. Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J. Mol. Biol. 351 (2005) 1081-1100
11. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 (1993) 971-983
12. Tobin A.J., and Signer E.R. Huntington's disease: the challenge for cell biologists. Trends Cell Biol. 10 (2000) 531-536
13. Vonsattel J.P., and DiFiglia M. Huntington disease. J. Neuropathol. Exp. Neurol. 57 (1998) 369-384
14. Krobitsch S., and Lindquist S. Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 1589-1594
15. Meriin A.B., Zhang X., He X., Newnam G.P., Chernoff Y.O., and Sherman M.Y. Huntingtin toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J. Cell Biol. 157 (2002) 997-1004
16. Meriin A.B., Zhang X., Miliaras N.B., Kazantsev A., Chernoff Y.O., McCaffery J.M., Wendland B., and Sherman M.Y. Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Mol. Cell. Biol. 23 (2003) 7554-7565
17. Gokhale K.C., Newnam G.P., Sherman M.Y., and Chernoff Y.O. Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model. J. Biol. Chem. 280 (2005) 22809-22818
18. 2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 2602-2607
19. Li S.H., Lam S., Cheng A.L., and Li X.J. Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis. Hum. Mol. Genet. 9 (2000) 2859-2867
20. Rose M.D., Winston F., and Hieter P. Laboratory Course Manuals for Methods in Yeast Genetics (1990), Cold Spring Harbor Laboratory Press, New York
21. Shirayama M., Zachariae W., Ciosk R., and Nasmyth K. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17 (1998) 1336-1349
22. Pozniakovsky A.I., Knorre D.A., Markova O.V., Hyman A.A., Skulachev V.P., and Severin F.F. Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast. J. Cell Biol. 168 (2005) 257-269
23. Madeo F., Herker E., Maldener C., Wissing S., Lachelt S., Herlan M., Fehr M., Lauber K., Sigrist S.J., Wesselborg S., and Frohlich K.U. A caspase-related protease regulates apoptosis in yeast. Mol. Cell 9 (2002) 911-917
24. Piatti S., Bohm T., Cocker J.H., Diffley J.F., and Nasmyth K. Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev. 10 (1996) 1516-1531
25. Mason D.A., Shulga N., Undavai S., Ferrando-May E., Rexach M.F., and Goldfarb D.S. Increased nuclear envelope permeability and Pep4p-dependent degradation of nucleoporins during hydrogen peroxide-induced cell death. FEMS Yeast Res. 5 (2005) 1237-1251
26. Fannjiang Y., Cheng W.C., Lee S.J., Qi B., Pevsner J., McCaffery J.M., Hill R.B., Basanez G., and Hardwick J.M. Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev. 18 (2004) 2785-2797
27. Skulachev V.P., Bakeeva L.E., Chernyak B.V., Domnina L.V., Minin A.A., Pletjushkina O.Y., Saprunova V.B., Skulachev I.V., Tsyplenkova V.G., Vasiliev J.M., Yaguzhinsky L.S., and Zorov D.B. Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis. Mol. Cell. Biochem. 256-257 (2004) 341-358
28. Madeo F., Frohlich E., Ligr M., Grey M., Sigrist S.J., Wolf D.H., and Frohlich K.-U. Oxygen stress: a regulator of apoptosis in yeast. J. Cell Biol. 145 (1999) 757-767
29. Wellingtonand C.L., and Hayden M.R. Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches. Clin. Genet. 57 (2000) 1-10
30. Schaffar G., Breuer P., Boteva R., Behrends C., Tzvetkov N., Strippel N., Sakahira H., Siegers K., Hayer-Hartl M., and Hartl F.U. Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol. Cell 15 (2004) 95-105
31. Turnell A.S., Stewart G.S., Grand R.J., Rookes S.M., Martin A., Yamano H., Elledge S.J., and Gallimore P.H. The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. Nature 438 (2005) 690-695
32. Husseman J.W., Nochlin D., and Vincent I. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. Neurobiol. Aging 21 (2000) 815-828
33. Greene L.A., Biswas S.C., and Liu D.X. Cell cycle molecules and vertebrate neuron death: E2F at the hub. Cell Death Differ. 11 (2004) 49-60
34. Burhans W.C., Weinberger M., Marchetti M.A., Ramachandran L., D'Urso G., and Huberman J.A. Apoptosis-like yeast cell death in response to DNA damage and replication defects. Mutat. Res. 532 (2003) 227-243
35. Weinberger M., Ramachandran L., Feng L., Sharma K., Sun X., Marchetti M., Huberman J.A., and Burhans W.C. Apoptosis in budding yeast caused by defects in initiation of DNA replication. J. Cell Sci. 118 (2005) 3543-3553