Iontophoresis itself on hairless mouse skin induces the loss of the epidermal calcium gradient without skin barrier impairment

Journal of Investigative Dermatology

Volumn 111, Issue 1, 1998, Pages 39-43

  Lee, Seung Hun ^a,d   Choi, Eung Ho ^b   Feingold, Kenneth R ^c   Jiang, Shaojun ^a   Ahn, Sung Ku ^b  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University Wonju   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Yonsei University College of Medicine   (South Korea)

Author keywords

Electron microscopy; Skin lipid barrier

Indexed keywords

CALCIUM ION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DERMIS; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; ELECTRON MICROSCOPY; EPIDERMIS; IONTOPHORESIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN ABSORPTION; SKIN WATER LOSS; STRATUM CORNEUM;

EID: 7144226580     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00226.x     Document Type: Article

References (20)

1. Burnette RR: Iontophoresis. In: Hadgraft J, Guy RH (eds.). Transdermal Drug Delivery: Developmental Issues and Research Initiatives. Marcel Dekker, New York, 1989, pp. 247-291
2. Burnette RR, Marrero D: Comparison between the iontophoretic and passive transport of thyrotropin releasing hormone across excised nude mouse skin. J Pharm Sci 75:738-743, 1986
3. Burnette RR. Ongpipattanakul B: Characterization of the pore transport properties and tissue alteration of excised human skin during iontophoresis. J Pharm Sci 77:132-137, 1988
4. Camel E, O'Connell M, Sage B, Gross M, Maibach H: The effect of saline iontophoresis on skin integrity in human volunteers. J Methodol Reproducibility Fundam Appl Toxicol 32:168-178, 1996
5. Chien YW, Siddiqui O, Shi M, Lelawongs P, Liu JC: Direct current iontophoretic transdermal delivery of peptide and protein drugs. J Pharm Sci 78:376-384, 1989
6. Green PG, Flanagan M, Shroot B, Guy RH: Iontophoretic drug delivery. In: Walters KA, Hadgraft J (eds.). Pharmaceutical Skin Penetration Enhancement. Marcel Dekker, New York, 1993, pp. 311-333
7. Grimnes S: Pathways of ionic flow through human skin in vivo. Acta Dermatol Venereol (Stockh) 64:93-98, 1984
8. Jiang SJ, Koo SW, Lee SH: The morphologic changes in lamellar bodies and intercomeocyte lipids after tape supping and occlusion with a water vapor-impermeable membrane. Arch Dermatol Res 290:145-151, 1998
9. Kalia YN, Nonato LB, Guy RH: The effect of iontophoresis on skin barrier integrity: non-invasive evaluation by impedance spectroscopy and transepidermal water loss. Pharm Res 13:957-960, 1996
10. Lee SH, Elias PM, Proksch E, Menon GK, Man M-Q, Feingold KR: Calcium and potassium are important regulators of barrier homeostasis in murine epidermis. J Clin Invest 89:530-538, 1992
11. Lee SH, Elias PM, Feingold KR, Mauro T: A role for ions in barrier recovery after acute pertubation. J Invest Dermatol 102:976-979, 1994
12. Lee RD, White HS, Scott ER: Visualization of iontophoretic transport paths in cultured and animal skin models. J Pharm Sci 85:1186-1190, 1996
13. Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Presence of intact intercellular lamellae in the upper layers of the stratum corneum. J Invest Dermatol 88:714-718, 1987
14. Menon GK, Grayson S, Elias PM: Ionic calcium reserviors in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 84:508-512, 1985
15. Menon GK, Elias PM, Lee SH, Feingold KR: Localization of calcium in murine epidermis following disruption and repair of permeability barrier. Cell Tiss Res 270:503-512, 1992a
16. Menon GK, Feingold KR, Elias PM: The lamellar body secretory response to barrier disruption. J Invest Dermatol 98:279-289, 1992b
17. Menon GK, Price LF, Bommannan B, Elias PM, Feingold KR: Selective obliteration of the epidermal calcium gradient leads to enhanced lamellar body secretion. J Invest Dermatol 102:789-795, 1994
18. Pechtold LARM, Abraham W, Potts RO: The influence of an electric field on ion and water accessibility to stratum corneum lipid lamellae. Pharm Res 13:1168-1173, 1996
19. Schaefer H, Redelmeier TE: Factors effecting percutaneous absorption. In: Schaefer H, Redelmeier TE (eds.). Skin Barrier: Principle of Percutaneous Absorption. Karger, Basel, 1996, pp. 153-212
20. Su MH, Srinivasan V, Ghanem AH, Higuchi WI: Quantitative in vivo iontophoretic studies. J Pharm Sci 83:12-17, 1994