Using expanded genetic alphabets to simplify high-throughput genetic testing

Expert Review of Molecular Diagnostics

Volumn 6, Issue 2, 2006, Pages 245-252

  Prudent, James R ^a  

^a EraGen Biosciences   (United States)

Author keywords

Automation; Diagnostic; Expanded; Genetic; Molecular; Multiplexing; Testing

Indexed keywords

DNA; NANOPARTICLE; PREDNISOLONE;

BASE PAIRING; DIAGNOSTIC PROCEDURE; DRUG STRUCTURE; GENE TECHNOLOGY; GENETIC ANALYSIS; HEALTH CARE SYSTEM; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; MEDICAL INSTRUMENTATION; MOLECULAR RECOGNITION; REVIEW; SEQUENCE ANALYSIS; SYSTEM ANALYSIS; CHEMICAL MODEL; CHEMISTRY; CPG ISLAND; GENETIC PROCEDURES; GENETIC SCREENING; METHODOLOGY; NANOTECHNOLOGY; NUCLEOTIDE SEQUENCE;

CPG ISLANDS; DNA; DNA MUTATIONAL ANALYSIS; GENETIC SCREENING; GENETIC TECHNIQUES; HUMANS; HYDROGEN BONDING; MODELS, CHEMICAL; NANOTECHNOLOGY;

EID: 33745481823     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.6.2.245     Document Type: Review

References (21)

1. Grosse SD, Boyle CA, Botkin JR et al. Wilfond newborn screening for cystic fibrosis evaluation of benefits and risks and recommendations for state newborn screening programs. MMWR Morb. Mortal. Wkly Rep. 53(RR-13), 1-36 (2004).
2. ACOG committee opinion. Prenatal and preconceptional carrier screening for genetic diseases in individuals of Eastern European Jewish descent. Number 298, August 2004. Obstet. Gynecol. 104(2), 425-428 (2004).
3. Benner SA. Chemistry. Redesigning genetics. Science 306, 625-626 (2004).
4. Piccirilli JA, Krauch T, Moroney SE, Benner SA. Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet. Nature 343, 33-37 (1990).
5. Geyer CR, Battersby TR, Benner SA. Nucleobase pairing in expanded Watson-Crick-like genetic information systems. Structure (Cambridge) 11(12), 1485-1498 (2003).
6. Hermann T, Patel DJ. Adaptive recognition by nucleic acid aptamers. Science 287(5454), 820-825 (2000).
7. Moser MJ, Prudent JR. Enzymatic repair of an expanded genetic information system. Nucleic Acids Res. 31, 5048-5053 (2003).
8. Code of Federal Regulations, Title 21, Volume 8 Cite:21 CFR864.4010
9. Johnson SC, Sherrill CB, Marshall DJ, Moser MJ, Prudent JR. A third base pair for the polymerase chain reaction: inserting isoC and isoG. Nucleic Acids Res. 32(6), 1937-1941 (2004).
10. Sherrill CB, Marshall DJ, Moser MJ, Larsen CA, Daude-Snow L, Prudent JR. Nucleic acid analysis using an expanded genetic alphabet to quench fluorescence. J. Am. Chem. Soc. 126(14), 4550-4556 (2004).
11. Johnson SC, Marshall DJ, Harms G et al. Multiplexed genetic analysis using an expanded genetic alphabet. Clin. Chem. 50(11), 2019-2027 (2004).
12. Ugozzoli LA. Multiplex assays with fluorescent microbead readout: a powerful tool for mutation detection. Clin. Chem. 50(11), 1963-1965 (2004).
13. Collins ML, Irvine B, Tyner D et al. A branched DNA signal amplification assay for quantification of nucleic acid targets below 100 molecules/ml. Nucleic Acids Res. 25(15), 2979-2984 (1997).
14. Landegren U, Kaiser R, Sanders J, Hood L. A ligase-mediated gene detection technique. Science 241, 1077-1080 (1988).
15. Oliphant A, Barker DL, Stuelpnagel JR, Chee MS. BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques Suppl. 56-58, 60-61 (2002).
16. Chen J, Iannone MA, Li MS et al. A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain extension. Genome Res. 10, 549-557 (2000).
17. Gibbons A, Amos M, Hodgson D. DNA computing. Curr. Opin. Biotechnol. 8,103-106 (1997).
18. Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature 346(6287), 818-822 (1990).
19. Moser MJ, Ruckstuhl M, Larsen CA et al. Quantifying mixed populations of drug-resistant human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 49(8), 3334-3340 (2005).
20. Moser MJ, Christensen DR, Norwood D, Prudent JR. Multiplexed detection of anthrax-related toxin genes. J. Mol. Diagn. 8(1), 89-96 (2006).
21. Genetic Screening of Newborn Infants: What Should We Test And Why? http://gslc.genetics.utah.edu/teachers/units/newborn/NGS-student%20packet.pdf