Amiodarone prophylaxis for atrial fibrillation of high-risk patients after coronary bypass grafting: A prospective, double-blinded, placebo-controlled, randomized study

European Heart Journal

Volumn 27, Issue 13, 2006, Pages 1584-1591

  Budeus, Marco ^a   Hennersdorf, Marcus ^b   Perings, Stefan ^b   Röhlen, Shinga ^b   Schnitzler, Stefan ^b   Felix, Oliver ^b   Reimert, Klaus ^b   Feindt, Peter ^b   Gams, Emmeran ^b   Lehmann, Nils ^a   Wieneke, Heinrich ^a   Sack, Stefan ^a   Erbel, Raimund ^a   Perings, Christian ^c  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Amiodarone; Atrial fibrillation; Coronary bypass grafting; P wave signal averaged ECG

Indexed keywords

AMIODARONE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PLACEBO; VERAPAMIL;

ADULT; AGED; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; COMPLETE HEART BLOCK; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; DOUBLE BLIND PROCEDURE; DRUG COST; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEART ATRIUM FIBRILLATION; HIGH RISK PATIENT; HOSPITAL COST; HUMAN; HYPOTENSION; ISCHEMIC HEART DISEASE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NAUSEA; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL;

AGED; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; CORONARY ARTERY BYPASS; DISEASE-FREE SURVIVAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTENSIVE CARE; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RISK FACTORS; TREATMENT OUTCOME;

EID: 33745453602     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehl082     Document Type: Article

References (27)

1. Mahoney EM, Thompson TD, Veledar E, Williams J, Weintraub WS. Cost-effectiveness of targeting patients undergoing cardiac surgery for therapy with intravenous amiodarone to prevent atrial fibrillation. J Am Coll Cardiol 2002;40:737-745.
2. Zimmer J, Pezzullp J, Choucair W, Southard J, Kokkinos P, Karasik P, Greenberg MD, Singh SN. Meta-analysis of antiarrhythmic therapy in the prevention of postoperative atrial fibrillation and the effect on hospital length of stay, costs, cerebrovascular accidents and mortality in patients undergoing cardiac surgery. Am J Cardiol 2003;9:1137-1140.
3. Budeus M, Hennersdorf M, Röhlen S, Schnitzler S, Felix O, Reimer K, Feindt P, Gams E, Wieneke H, Sack S, Erbel R, Perings C. Predicting of atrial fibrillation after coronary bypass grafting: The role of chemoreflex-sensitivity and P wave signal averaged ECG. Int J Cardiol 2006;106:67-74.
4. Zaman AG, Archbold RA, Helft G, Paul EA, Curzen NP, Mills PG. Atrial fibrillation after coronary artery bypass surgery. A model of preoperative risk stratification. Circulation 2000;101:1403-1408.
5. Stafford PJ, Kolvekar S, Cooper J, Fothergill J, Schlindwein F, de Bono DP, Spyt TJ, Garratt CJ. Signal averaged P wave compared with electrocardiography or echocardiography for prediction of atrial fibrillation after coronary bypass grafting. Heart 1997;77:417-422.
6. Aytemir K, Aksoyek S, Ozer N, Sait A, Oto A. Atrial fibrillation after coronary artery bypass surgery: P wave signal averaged ECG, clinical and angiographic variables in risk assessment. Int J Cardiol 1999;69:49-56.
7. Crystal E, Connolly SJ, SLeik K, Ginger TJ, Yusuf S. Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery: a meta-analysis. Circulation 2002;106:75-80.
8. Kowey PR, Taylor JE, Rials SJ, Marinchak RA. Meta-analysis of the effectiveness of prophylactic drug therapy in prevention supraventricular arrhythmia early after coronary artery bypass grafting. Am J Cardiol 1992;69:963-965.
9. Zipes DP, Prystowsky EN, Heger JJ. Amiodarone: electrophysiologic actions, pharmacokinetics and clinical effects. J Am Coll Cardiol 1984;3:1059-1071.
10. Kalman JM, Munawar M, Howes LG, Louis WJ, Buxton BF, Gutteridge G, Tonkin AM. Atrial fibrillation after coronary artery bypass grafting is associated with sympathetic activation. Ann Thorac Surg 1995;60:1709-1715.
11. Debbas N, du Cailar C, Sassine A, Derancourt J, Demaille J, Puech P. Determination of cardiac and plasma drug levels during long term amiodarone therapy. Eur J Clin Pharmacol 1983;13:69-81.
12. Redle JD, Khurana S, Marzan R, Mc Cullough PA, Stewart JR, Westveer DC, O'Neill WW, Bassett JS, Tepe NA, Frumin HI. Prophylactic oral amiodarone compared with placebo for prevention of atrial fibrillation after coronary artery bypass surgery. Am Heart J 1999;138:144-150.
13. Hohnloser SH, Meinertz T, Dammbacher T, Steiert K, Jähnchen E, Zehender M, Fraedrich G, Just H. Electrocardiographic and antiarrhythmic effects of intravenous amiodarone: Results of a prospective, placebo controlled study. Am Heart J 1991;121:89-95.
14. Dorge H, Schoendube FA, Schoberer M, Stellbrink C, Voss M, Messmer BJ. Intraoperative amiodarone as prophylaxis against atrial fibrillation after coronary operations. Ann Thorac Surg 2000;69:1358-1362.
15. Lee SH, Chang CM, Lu MJ, Lee RJ, Cheng JJ, Hung CR, Chen SA. Intravenous amiodarone for prevention of atrial fibrillation after coronary artery bypass grafting. Ann Thorc Surg 2000;70:157-161.
16. Butler J, Harriss DR, Sinclair M, Westaby S. Amiodaron prophylaxis for tachycardias after coronary artery bypass surgery: a randomised, double blind, placebo controlled trial. Br Heart J 1993;70:56-60.
17. Tokmakoglu H, Kandemir O, Gunaydin S, Catav Z, Yorgancioglu C, Zorlutuna Y. Amiodarone vs. digoxin and metoprolol combination for prevention of postcoronary bypass atrial fibrillation. Eur J Cardiothorac Surg 2002;21:401-405.
18. Daoud EG, Strickberger SA, Man KC, Goyal R, Deeb GM, Bolling SF, Pagani FD, Bitar C, Meissnere MD, Morady F. Preoperative amiodarone as prophylaxis against atrial fibrillation after heart surgery. N Eng J Med 1997;337:1785-1791.
19. Guarnieri T, Nolan S, Gottlieb SO, Dudek A, Lowry DR. Intravenous amiodarone for prevention of atrial fibrillation after open heart surgery: The Amiodarone Reduction in Coronary Heart (ARCH) Trial. J Am Coll Cardiol 1999;34:343-347.
20. Giri S, White MC, Dunn BD, Felton K, Freeman-Bosco L, Reddy P, Tsikouris JP, Wilcox HA, Kluger J. Oral amiodarone for prevention of atrial fibrillation after heart surgery, the Atrial Fibrillation Suppression Trial (AFIST): a randomised placebo-controlled trial. Lancet 2001;357:830-836.
21. Riva E, Gerna M, Latini R, Giani P, Volpi A, Maggioni A. Pharmacokinetics of amiodarone in man. J Cardiovasc Pharmacol 1982;4:264-269.
22. Meng X, Mojaverian P, Doedee M, Lin E, Weinryb I, Chiang ST, Kowey PR. Bioavailability of amiodarone tablets administered with and without food in healthy subjects. Am J Cardiol 2001;87:432-435.
23. Libersa CC, Brique SA, Motte KB, Caron JF, Guedon-Moreau LM, Humbert L, Vincent A, Devos P, Lhermitte MA. Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. Br J Clin Pharmacol 2000;49:373-378.
24. Ohyama K, Nakajima M, Nakamura S, Shimada N, Yamazaki H, Yokoi T. A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approch to predict the contribution with relative activity factor. Drug Metab Dispos 2000;11:1303-1310.
25. Soyama A, Hanioka N, Saito Y, Murayama N, Ando M, Ozawa S, Sawada J. Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A. Pharmacol Toxicol 2002;91:174-178.
26. Haan CK, Geraci SA. Role of amiodarone in reducing atrial fibrillation after cardiac surgery in adults. Ann Thorac Surg 2002;73:1665-1669.
27. Zimmer J, Pezzullo J, Choucair W, Southard J, Kokkinos P, Karasik P, Greenberg MD, Singh SN. Meta-analysis of antiarrhythmic therapy in the prevention of postoperative atrial fibrillation and the effect on hospital length of stay, costs, cerebrovascular accidents, and mortality in patients undergoing cardiac surgery. Am J Cardiol 2003;91:1137-1140.