Effects of co-administration of an iNOS inhibitor with a broad-spectrum reactive species scavenger in rat renal ischemia/reperfusion injury

Nephron - Experimental Nephrology

Volumn 103, Issue 3, 2006, Pages

  Zahmatkesh, M ^a   Kadkhodaee, M ^a   Arab, H A ^b   Shams, S ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Acute renal failure; Ischemia reperfusion; Reactive oxygen species

Indexed keywords

CREATININE; INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN; N ACETYL BETA GLUCOSAMINIDASE; N6 (1 IMINOETHYL)LYSINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; UREA;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG MECHANISM; ENZYME ACTIVITY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL ARTERY; RENAL PROTECTION; REPERFUSION INJURY; UREA NITROGEN BLOOD LEVEL;

ANIMALS; DRUG COMBINATIONS; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GLUTATHIONE; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES; LYSINE; MALE; METALLOPORPHYRINS; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 33745453142     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000092197     Document Type: Article

References (27)

1. Nath KA, Norby SM: Reactive oxygen species and acute renal failure. Am J Med 2000;109:655-678.
2. Walker LM, York JL, Imam SZ, Ali SF, Muldrew KL, Mayeux PR: Oxidative stress and reactive nitrogen species generation during renal ischemia. Toxicol Sci 2001;63:143-148.
3. Noiri E, Nakao A, Uchida K, Tsukahara H, Ohno M, Fujita T, Brodsky S, Goligorsky MS: Oxidative and nitrosative stress in acute renal ischemia. Am J Physiol 2001;281:F948-F957.
4. Kadkhodaee M, Hanson GR, Towner RA, Endre ZH: Detection of hydroxyl and carbon-centred radicals by EPR spectroscopy after ischaemia and reperfusion of the rat kidney. Free Radic Res 1996;25:31-42.
5. Yu L, Gengaro PE, Niederberger M, Burke TJ, Schrier RW: Nitric oxide: a mediator in rat tubular hypoxia/reoxygenation injury. Proc Natl Acad Sci USA 1994;91:1691-1695.
6. Noiri E, Peresleni T, Miller F, Goligorsky MS: In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J Clin Invest 1996;97:2377-2383.
7. Stamler JS, Singel DJ, Loscalzo J: Biochemistry of nitric oxide and its redox-activated forms. Science 1992;258:1898-1902.
8. Clementi E, Brown GC, Feelisch M, Moncada S: Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 1998;95:7631-7636.
9. Zahmatkesh M, Kadkhodaee M, Shid Moosavi SM, Jorjani M, Kajbafzadeh A, Golestani A, Ghaznavi R: Beneficial effects of MnTBAP, a broad spectrum reactive species scavenger, in rat renal ischemia/reperfusion injury. Clin Exp Nephrol 2005;9:212-218.
10. Patel M, Day BJ: Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol Sci 1999;20:359-364.
11. Salvemini D, Cuzzocrea S: Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine. Crit Care Med 2003;31:S29-S38.
12. Bao F, DeWitt DS, Prough DS, Liu D: Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) Tetrakis (4-benzoic acid) porphyrin. J Neurosci Res 2003;71:220-227.
13. Cuzzocrea S, Costantino G, Mazzon E, De Sarro A, Caputi AP: Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock. Br J Pharmacol 1999;128:1241-1251.
14. Day BJ, Fridovich I, Crapo JD: Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys 1997;347:256-262.
15. Faraci WS, Nagel AA, Verdries KA, Vincent LA, Xu H, Nichols LE, Labasi JM, Salter ED, Pettipher ER: 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. Br J Pharmacol 1996;119:1101-1108.
16. Price RG: Urinary enzymes, nephrotoxicity and renal disease. Toxicology 1982;23:99-134.
17. Horak E, Hopfer SM, Sunderman FW: Spectrophotometric assay for urinary N-acetyl-β-D-glucosaminidase activity. Clin Chem 1981; 2777:1180-1185.
18. Lockwood TD, Bosmann HB: The use of urinary N-acetyl-β-D- glucosaminidase in human renal toxicity. I. Partial biochemical characterization and excretion in humans and release from the isolated perfused rat kidney. Toxicol Appl Pharmacol 1979;49:323-336.
19. Miranda KM, Espey MG, Wink DA: A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001;5:62-71.
20. Griffith OW: Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 1980;106:207-212.
21. Zingareli B, Day BJ, Crapo JD, Salzman AL, Szabo C: The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br J Pharmacol 1997;120:259-267.
22. Walker LM, Walker PD, Imam SZ, Ali SF, Mayeux PR: Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor 1-n6-(1-iminoethyl) lysine. J Pharmacol Exp Ther 2000;295:417-422.
23. Szabo C, Day BJ, Salzman AL: Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett 1996;381:82-86.
24. Hunley TE, Kon V: Endothelin in ischemic acute renal failure. Curr Opin Nephrol Hypertens 1997;6:394-400.
25. Hughes AK, Stricklett PK, Padilla E, Kohan DE: The interaction between oxygen radicals and endothelin-1 may represent a mechanism that contributes to the pathophysiology of renal ischemia/reperfusion injury. Kid Int 1996;49:181-189.
26. Kurata H, Takaoka M, Kubo Y, Katayama T, Tsutsui H, Takayama J, Matsumura Y: Nitric oxide protects against ischemic acute renal failure through the suppression of renal endothelin-1 overproduction. J Cardiovasc Pharmacol 2004;44:S455-S458.
27. Asakura H, Asamura R, Ontachi Y, Hayashi T, Yamazaki M, Morishita E, Miyamoto KI, Nakao S: Selective inducible nitric oxide synthase inhibition attenuates organ dysfunction and elevated endothelin levels in LPS-induced DIC model rats. J Thromb Haemost 2005;3:1050-1055.