Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas

American Journal of Pathology

Volumn 157, Issue 2, 2000, Pages 353-359

  Dannenberg, Hilde ^a,b   Speel, Ernst J M ^c   Zhao, Jianming ^c   Saremaslani, Parvin ^c   Van der Harst, Erwin ^b   Roth, Jürgen ^c   Heitz, Philipp U ^c   Bonjer, H Jaap ^b   Dinjens, Winand N M ^a   Mooi, Wolter J ^a   Komminoth, Paul ^c   De Krijger, Ronald R ^a  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANEUPLOIDY; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CHROMOSOME 11Q; CHROMOSOME 17P; CHROMOSOME 17Q; CHROMOSOME 1P; CHROMOSOME 3P; CHROMOSOME 3Q; CHROMOSOME 6Q; CHROMOSOME 9Q; CHROMOSOME DELETION; CHROMOSOME LOSS; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MALE; PHEOCHROMOCYTOMA; PRIORITY JOURNAL;

EID: 0033888975     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64547-6     Document Type: Article

References (45)

1. Malignant pheochromocytoma: Clinical, biological, histologic and therapeutic data in a series of 20 patients with distant metastases
2. The MEN2 syndromes and the role of the ret proto-oncogene
3. Von Hippel-Lindau syndrome
4. Neurofibromatosis and cancer
5. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
6. Identification of the von Hippel-Lindau tumour suppressor gene
7. Molecular genetic analysis of von Hippel-Lindau disease
8. Identification of intragenic mutations in the von Hippel-Lindau disease tumor suppressor gene and correlation with disease phenotype
9. Human genetics: Neurofibromatosis gene cloned
10. Prognostic value of RET proto-oncogene point mutations in malignant and benign, sporadic phaeochromocytomas
11. Germline mutations in the vhl gene in patients presenting with phaeochromocytomas
12. Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas
13. Loss of neurofibromatosis type I (NF1) gene expression in pheochromocytomas from patients without NF1
14. Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma
15. Deletion analysis of the p 16 tumour suppressor gene in phaeochromocytomas
16. Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas
17. The relatively high frequency of p53 gene mutations in multiple and malignant phaeochromocytomas
18. Expression and prognostic value of c-erbB-2 oncogene product in human phaeochromocytomas
19. Prognostic value of p53, bcl-2, and c-erbB-2 protein expression in phaeochromocytomas
20. Expression patterns of the c-myc gene in adrenocortical tumors and pheochromocytomas
21. Loss of heterozygosity on chromosomes 1p and 11p in sporadic pheochromocytoma
22. Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas
23. Consistent association of 1p loss of heterozygosity with pheochromocytomas from patients with multiple endocrine neoplasia type 2 syndrome
24. Loss of heterozygosity on the short arm of chromosomes and 3 in sporadic pheochromocytoma and extra-adrenal paraganglioma
25. Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma
26. Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization
27. Cloning of human satellite III DNA: Different components are on different chromosomes
28. Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma
29. A hypervariable repeated sequence on human chromosome 1p36
30. Chromosome specificity of satellite DNAs: Short and long-range organization of a diverged dimeric subset of human alpha satellite from chromosome 3
31. Characterization of a cloned DNA sequence that is present at centromeres of all human autosomes and the X chromosome and shows polymorphic variation
32. Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells
33. Isolation and mapping of 68 RFLP markers on human chromosome 6
34. MEN 1 gene mutations in sporadic adrenocortical lesions
35. Analysis of genomic alterations in sporadic adrenocortical lesions: Gain of chromosome 17 is an early event in adrenocortical tumorigenesis
36. Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: Correlation with N-myc amplification
37. Deletion mapping on the distal third region of cnromosome 1p in multiple endocrine neoplasia type IIA
38. Acquired homozygosity (isodisomy) of chromosome 3 in uveal melanoma
39. Localization of a novel tumor suppressor locus on human chromosome 3q important in osteosarcoma tumorigenesis
40. Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lympnoma
41. Multiple regions of allelic loss from chromosome arm 6q in malignant mesothelioma
42. Prognostic significance of allelic losses in primary melanoma
43. Genetic differences in endocrine pancreatic tumor subtypes detected by comparative genomic hybridization
44. Involvement of multiple cnromosome 17p loci in medulloblastoma tumorigenesis
45. Comparative genomic hybridization analysis of sporadic neuroendocrine tumors of the digestive system