Expression of MG7-Ag in patients with gastric cancer correlates with weaker T cell immune response and more proinflammatory cytokine secretion

Biochemistry and Cell Biology

Volumn 84, Issue 2, 2006, Pages 135-141

  Zhang, Xiaoyin ^a   Hong, Liu ^a   Chan, W Y ^b   Qiao, Taidong ^a   Chen, Baojun ^a   Liu, Y ^b   Fan, Daiming ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cytokine; Gastric carcinoma; RT PCR; T cell receptor repertoire; Tumor associated antigen

Indexed keywords

ANTIGENS; CELLS; CORRELATION METHODS; ENZYME KINETICS; IMMUNOLOGY; PATIENT MONITORING; TUMORS;

CYTOKINE; CYTOKINE SECRETION; GASTRIC CANCER; GASTRIC CARCINOMA; RT-PCR; T CELL RECEPTOR REPERTOIRE; TUMOR ASSOCIATED ANTIGEN;

DISEASE CONTROL;

ANTIGEN; INTERLEUKIN 8; MG7 AG ANTIGEN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RNA, MESSENGER; RNA, NEOPLASM; STOMACH NEOPLASMS; T-LYMPHOCYTES;

EID: 33745407111     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o05-174     Document Type: Article

References (40)

1. Abrams, S.I. 2004. Regulation of tumor progression by anti-neoplastic T cell responses. Cancer Biol. Ther. 3(2): 140-146.
2. + T cell-dependent tumor eradication in vivo. J. Immunol. 165: 5495-5501.
3. Cohen, M.C., and Cohen, S. 1996. Cytokine function: a study in biologic diversity. Am. J. Clin. Pathol. 105: 589-598.
4. + T lymphocytes. Cancer Immunol. Immunother. 50: 673-681.
5. Flieger, D., Hoff, A.S., and Sauerbruch, T. 2001. Influence of cytokines, monoclonal antibodies and chemotherapeutic drugs on epithelial cell adhesion molecule (EpCAM) and LewisY antigen expression. Clin. Exp. Immunol. 123: 9-14.
6. Gaudin, C., Dietrich, P.Y., and Robache, S. 1995. In vivo local expansion of clonal T cell subpopulations in renal cell carcinoma. Cancer Res. 55: 685-690.
7. Gorski, J., Yassai, M., and Zhu, X. 1994. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. J. Immunol. 152: 5109-5119.
8. Guo, C.C., Ding, J., Pan, B.R., Yu, Z.C., Han, Q.L., Meng, F.P. et al. 2003. Development of an oral DNA vaccine against MG7-Ag of gastric cancer using attenuated salmonella typhimurium as carrier. World J. Gastroenterol. 9(6): 1191-1195.
9. Hassfeld, W., Steiner, G., Studnicka-Benke, A., Skriner, K., Graninger, W., Fischer, I., and Smolen, J.S. 1995. Autoimmune response to the spliceosome. An immunologic link between rheumatoid arthritis, mixed connective tissue disease, and systemic lupus erythematosus. Arthritis Rheum. 38(6): 777-785.
10. He, Y., Brown, M.A., Rothnagel, J.A., Saunders, N.A., and Smith, R. 2005. Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation. J. Cell Sci. 118(Pt. 14): 3173-3183.
11. Hu, H.M., Urba, W.J., and Fox, B.A. 1998. Gene modified tumor vaccine with therapeutic potential shifts tumor-specific T cell response from a type 2 to a type 1 cytokine profile. J. Immunol. 161: 3033-3041.
12. Inglot, A.D., Gelder, F., and Georgiades, J.A. 1998. Tumor-associated antigens are cytokine inducers and hyporeactivity factors to the immune system. Biotherapy, 11: 27-37.
13. Iwanaga, K., Sueoka, N., Sato, A., Hayashi, S., and Sueoka, E. 2005. Heterogeneous nuclear ribonucleoprotein B1 protein impairs DNA repair mediated through the inhibition of DNA-dependent protein kinase activity. Biochem. Biophys. Res. Commun. 333(3): 888-895.
14. Kim, J.A., Dayton, M.A., and Aldrich, W. 1999. Modulation of CD4 cell cytokine production by colon cancer-associated mucin. Cancer Immunol. Immunother. 48: 525-532.
15. Kuninaka, S., Yano, T., and Yokoyama, H. 2000. Direct influences of pro-inflammatory cytokines (IL-1beta, TNF-alpha, IL-6) on the proliferation and cell-surface antigen expression of cancer cells. Cytokine, 12: 8-11.
16. Lee, C.H., Lum, J.H., Cheung, B.P., Wong, M.S., Butt, Y.K., Tam, M.F. et al. 2005. Identification of the heterogeneous nuclear ribonucleoprotein A2/B1 as the antigen for the gastrointestinal cancer specific monoclonal antibody MG7. Proteomics, 5(4): 1160-1166.
17. Liu, J., Zhang, X.Y., and Fan, D.M. 2002. The value of MG7 antigen in predicting cancerous change in displastic gastric mucosa. Int. J. Clin. Pract. 56: 169-172.
18. Meng, F., Ding, J., Yu, Z.C., Han, Q.L., Guo, C.C., Liu, N., and Fan, D.M. 2005. Oral attenuated Salmonella typhimurium vaccine against MG7-Ag mimotope of gastric cancer. World J. Gastroenterol. 11(12): 1833-1836.
19. Merogi, A.J., Marrogi, A.J., Ramesh, R., Robinson, W.R., Fermin, C.D., and Freeman, S.M. 1997. Tumor-host interaction: analysis of cytokines, growth factors, and tumor-infiltrating lymphocytes in ovarian carcinomas. Hum. Pathol. 28: 321-331.
20. Miyamoto, M., Shimizu, Y., and Okada, K. 1998. Effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells. Cancer Immunol. Immunother. 47: 47-57.
21. Mocellin, S., Wang, E., and Marincola, F.M. 2001. Cytokines and immune response in the tumor microenvironment. J. Immunother. 24: 392-407.
22. Nagorsen, D., Wang, E., Marincola, F.M., and Even, J. 2002. Transcriptional analysis of tumor-specific T-cell responses in cancer patients. Crit. Rev. Immunol. 22(5-6): 449-462.
23. Pardoll, D.M. 1994. Tumour antigens. A new look for the 1990s. Nature (London), 369: 357-359.
24. Ren, J., Fan, D.M., and Zhou, S.J. 1994. Establishment of immuno-PCR technique for the detection of tumor associated antigen MG7-Ag on the gastric cancer cell line. Zhonghua Zhongliu Zazhi, 16: 247-250.
25. Ren, J., Chen, Z., and Juan, S.J. 2000. Detection of circulating gastric carcinoma-associated antigen MG7-Ag in human sera using an established single determinant immuno-polymerase chain reaction technique. Cancer, 88: 280-285.
26. Rosen, H.R., Ausch, C., and Reinerova, M. 1998. Activated lymphocytes from breast cancer patients express the characteristics of type 2 helper cells - a possible role for breast cancer-associated p43. Cancer Lett. 127: 129-134.
27. Shi, R., Hong, L., and Wu, D. 2005. Enhanced immune response to gastric cancer specific antigen peptide by coencapsulation with CpG oligodeoxynucleotides in nanoemulsion. Cancer Biol. Ther. 4(2): 218-224.
28. Slovin, S.F., Keding, S.J., and Ragupathi, G. 2005. Carbohydrate vaccines as immunotherapy for cancer. Immunol. Cell Biol. 83(4): 418-428.
29. Sueoka, E., Goto, Y., Sueoka, N., Kai, Y., Kozu, T., and Fujiki, H. 1999. Heterogeneous nuclear ribonucleoprotein B1 as a new marker of early detection for human lung cancers. Cancer Res. 59(7): 1404-1407.
30. Smyth, M.J., Cretney, E., Kershaw, M.H., and Hayakawa, Y. 2004. Cytokines in cancer immunity and immunotherapy. Immunol. Rev. 202: 275-293.
31. + T cells from patients with melanoma or renal cell carcinoma. Clin. Cancer Res. 9(3): 947-954.
32. Thyphronitis, G., and Koutsilieris, M. 2004. Boosting the immune response: an alternative combination therapy for cancer patients. Anticancer Res. 24(4): 2443-2453.
33. Tilg, H., Dinarello, C.A., and Mier, J.W. 1997. IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol. Today, 18: 428-432.
34. Wagner, S.N., Schultewolter, T., Wagner, C., Briedigkeit, L., Becker, J.C., Kwasnicka, H.M., and Goos, M. 1998. Immune response against human primary malignant melanoma: a distinct cytokine mRNA profile associated with spontaneous regression. Lab. Investig. 78(5): 541-550.
35. Wu, S., Boyer, C.M., and Whitaker, R.S. 1993. Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. Cancer Res. 53: 1939-1944.
36. Xu, L., Jin, B.-q., and Fan, D.-m. 2003. Selection and identification of mimic epitopes for gastric cancer-associated antigen MG7-Ag. Mol. Cancer Ther. 2: 301-306.
37. Yan-Sanders, Y., Hammons, G.J., and Lyn-Cook, B.D. 2002. Increased expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP) in pancreatic tissue from smokers and pancreatic tumor cells. Cancer Lett. 183(2): 215-220.
38. Ying, H., Zeng, G., and Black, K.L. 2001. Innovative cancer vaccine strategies based on the identification of tumour-associated antigens. BioDrugs, 15: 819-831.
39. Zhang, X.Y., Chan, W.Y., and Whitney, B.M. 2001. T-cell receptor Vβ repertoire expression reflects gastric carcinoma progression. Clin. Immunol. 101: 3-7.
40. Zhang, X.Y., Chan, W.Y., Whitney, B.M., Fan, D.M., Chow, J.H., Liu, Y. et al. 2002. Changes of interleukin expression correlate with Helicobacter pylori infection and lymph node metastases in gastric carcinoma. Diagn. Mol. Pathol. 11(3): 135-139.