Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 127, Issue 1, 2006, Pages 41-49

  Wareing, Mark ^a   Myers, Jenny E ^a   O'Hara, Maureen ^a   Kenny, Louise C ^a   Taggart, Michael J ^a   Skillern, Laurence ^b   Machin, Ian ^b   Baker, Philip N ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Human; Omentum; Phosphodiesterase 5 inhibitors; Placenta; Pre eclampsia

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; ARGIPRESSIN; BRADYKININ; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; THROMBOXANE; UK 343664; UNCLASSIFIED DRUG;

ARTERY; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; BIOPSY; CARDIOVASCULAR FUNCTION; CESAREAN SECTION; CHORION VILLUS; CONTROLLED STUDY; DISSECTION; FEMALE; HUMAN; HUMAN TISSUE; INCUBATION TIME; MYOMETRIUM; OMENTUM; PLACENTA; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 33745406314     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2004.06.014     Document Type: Article

References (51)

1. CESDI, Confidential enquiry into stillbirths and deaths in infancy. Fifth annual report. Maternal and child health research consortium; 1998
2. Lain K.Y., and Roberts J.M. Contemporary concepts of the pathogenesis and management of preeclampsia. J. Am. Med. Assoc. 287 24 (2002) 3183-3186
3. Roberts J.M., and Lain K.Y. Recent insights into the pathogenesis of pre-eclampsia. Placenta 23 5 (2002) 359-372
4. Lunell N.O., Lewander R., Mamoun I., Nylund L., Sarby S., and Thornstrom S. Uteroplacental blood flow in pregnancy induced hypertension. Scand. J. Clin. Lab. Invest. Suppl. 169 (1984) 28-35
5. Zhou Y., Fisher S.J., Janatpour M., et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?. J. Clin. Invest. 99 9 (1997) 2139-2151
6. Ferris T.F. Pregnancy, preeclampsia, and the endothelial cell. N. Engl. J. Med. 325 20 (1991) 1439-1440
7. de Groot C.J., and Taylor R.N. New insights into the etiology of pre-eclampsia. Ann. Med. 25 3 (1993) 243-249
8. Dekker G.A. Etiology and pathophysiology of preeclampsia. Zentralbl. Gynakol. 116 2 (1994) 57-60
9. Friedman S.A., Schiff E., Emeis J.J., Dekker G.A., and Sibai B.M. Biochemical corroboration of endothelial involvement in severe preeclampsia. Am. J. Obstet. Gynecol. 172 1 (Pt. 1) (1995) 202-203
10. Roberts J.M., Taylor R.N., Musci T.J., Rodgers G.M., Hubel C.A., and McLaughlin M.K. Preeclampsia: an endothelial cell disorder. Am. J. Obstet. Gynecol. 161 5 (1989) 1200-1204
11. Roberts J.M., and Redman C.W. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet 341 8858 (1993) 1447-1451
12. McCarthy A.L., Woolfson R.G., Raju S.K., and Poston L. Abnormal endothelial cell function of resistance arteries from women with preeclampsia. Am. J. Obstet. Gynecol. 168 4 (1993) 1323-1330
13. Ashworth J.R., Warren A.Y., Baker P.N., and Johnson I.R. Loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsia. Br. J. Obstet. Gynaecol. 104 10 (1997) 1152-1158
14. Cockell A.P., and Poston L. Flow-mediated vasodilatation is enhanced in normal pregnancy but reduced in preeclampsia. Hypertension 30 2 (Pt. 1) (1997) 247-251
15. Knock G.A., and Poston L. Bradykinin-mediated relaxation of isolated maternal resistance arteries in normal pregnancy and preeclampsia. Am. J. Obstet. Gynecol. 175 6 (1996) 1668-1674
16. Pascoal I.F., Lindheimer M.D., Nalbantian-Brandt C., and Umans J.G. Preeclampsia selectively impairs endothelium-dependent relaxation and leads to oscillatory activity in small omental arteries. J. Clin. Invest. 101 2 (1998) 464-470
17. Kenny L.C., Baker P.N., Kendall D.A., Randall M.D., and Dunn W.R. Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsia. Clin. Sci. 103 1 (2002) 67-73
18. Davidge S.T., Stranko C.P., and Roberts J.M. Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia. Am. J. Obstet. Gynecol. 174 3 (1996) 1008-1013
19. Smarason A.K., Allman K.G., Young D., and Redman C.W. Elevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre-eclampsia. Br. J. Obstet. Gynaecol. 104 5 (1997) 538-543
20. Ranta V., Viinikka L., Halmesmaki E., and Ylikorkala O. Nitric oxide production with preeclampsia. Obstet. Gynecol. 93 3 (1999) 442-445
21. Davidge S.T., Baker P.N., and Roberts J.M. NOS expression is increased in endothelial cells exposed to plasma from women with preeclampsia. Am. J. Physiol. 269 3 (Pt 2) (1995) 1106-1112
22. Baker P.N., Davidge S.T., and Roberts J.M. Plasma from women with preeclampsia increases endothelial cell nitric oxide production. Hypertension 26 2 (1995) 244-248
23. Davidge S.T. Oxidative stress and altered endothelial cell function in preeclampsia. Semin. Reprod. Endocrinol. 16 1 (1998) 65-73
24. Roggensack A.M., Zhang Y., and Davidge S.T. Evidence for peroxynitrite formation in the vasculature of women with preeclampsia. Hypertension 33 1 (1999) 83-89
25. Cooke C.L., and Davidge S.T. Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Am. J. Physiol. Cell Physiol. 282 2 (2002) 395-402
26. Lees C., Valensise H., Black R., et al. The efficacy and fetal-maternal cardiovascular effects of transdermal glyceryl trinitrate in the prophylaxis of pre-eclampsia and its complications: a randomized double-blind placebo-controlled trial. Ultrasound Obstet. Gynecol. 12 5 (1998) 334-338
27. Wallis R.M., Corbin J.D., Francis S.H., and Ellis P. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am. J. Cardiol. 83 5A (1999) 3C-12C
28. Zusman R.M. Cardiovascular data on sildenafil citrate: introduction. Am. J. Cardiol. 83 5A (1999) 1C-2C
29. Bivalacqua T.J., Champion H.C., Hellstrom W.J., and Kadowitz P.J. Pharmacotherapy for erectile dysfunction. Trends Pharmacol. Sci. 21 12 (2000) 484-489
30. Jackson G., Benjamin N., Jackson N., and Allen M.J. Effects of sildenafil citrate on human hemodynamics. Am. J. Cardiol. 83 5A (1999) 13C-20C
31. Wareing M., Kenny L.C., Warren A.Y., et al. Rescue of endothelial function by a PDE5 inhibitor: a potential therapy for pre-eclampsia? Hypertension in pregnancy 21 Suppl. 1 (2002) 3
32. Bonnell M.R., Urdaneta F., Kirby D.S., Valdez N.R., Beaver T.M., and Lobato E.B. Effects of sildenafil analogue UK 343-664 on a porcine model of acute pulmonary hypertension. Ann. Thorac. Surg. 77 1 (2004) 238-242
33. Davey D.A., and MacGillivray I. The classification and definition of the hypertensive disorders of pregnancy. Am. J. Obstet. Gynecol. 158 4 (1988) 892-898
34. Wilcox M.A., Johnson I.R., Maynard P.V., Smith S.J., and Chilvers C.E. The individualised birthweight ratio: a more logical outcome measure of pregnancy than birthweight alone. Br. J. Obstet. Gynaecol. 100 4 (1993) 342-347
35. Wareing M., Crocker I.P., Warren A.Y., Taggart M.J., and Baker P.N. Characterization of small arteries isolated from the human placental chorionic plate. Placenta 23 5 (2002) 400-409
36. Dunn W.R., Wellman G.C., and Bevan J.A. Enhanced resistance artery sensitivity to agonists under isobaric compared with isometric conditions. Am. J. Physiol. 266 1 (Pt 2) (1994) H147-H155
37. Suzuki Y., Kajikuri J., Suzumori K., and Itoh T. Mechanisms underlying the reduced endothelium-dependent relaxation in human omental resistance artery in pre-eclampsia. J. Physiol. 527 Pt 1 (2000) 163-174
38. Suzuki Y., Saitoh M., Suzumori K., Kajikuri J., and Itoh T. Characterization of changes in mechanical responses to histamine in omental resistance arteries in pre-eclampsia. Br. J. Pharmacol. 131 1 (2000) 37-42
39. Suzuki Y., Yamamoto T., Suzumori K., Kajikuri J., and Itoh T. Modified histamine-induced NO-mediated relaxation in resistance arteries in pre-eclampsia. Eur. J. Pharmacol. 410 1 (2000) 7-13
40. Suzuki Y., Hattori T., Kajikuri J., Yamamoto T., Suzumori K., and Itoh T. Reduced function of endothelial prostacyclin in human omental resistance arteries in pre-eclampsia. J. Physiol. 545 Pt 1 (2002) 269-277
41. Buus N.H., VanBavel E., and Mulvany M.J. Differences in sensitivity of rat mesenteric small arteries to agonists when studied as ring preparations or as cannulated preparations. Br. J. Pharmacol. 112 2 (1994) 579-587
42. Falloon B.J., Stephens N., Tulip J.R., and Heagerty A.M. Comparison of small artery sensitivity and morphology in pressurized and wire-mounted preparations. Am. J. Physiol. 268 22 (1995) 670-678
43. Nagao T., Illiano S., and Vanhoutte P.M. Heterogeneous distribution of endothelium-dependent relaxations resistant to NG-nitro-l-arginine in rats. Am. J. Physiol. 263 4 (Pt 2) (1992) H1090-H1094
44. Woolfson R.G., and Poston L. Effect of NG-monomethyl-l-arginine on endothelium-dependent relaxation of human subcutaneous resistance arteries. Clin. Sci. (Lond.) 79 3 (1990) 273-278
45. Lyall F., Young A., and Greer I.A. Nitric oxide concentrations are increased in the fetoplacental circulation in preeclampsia. Am. J. Obstet. Gynecol. 173 3 (Pt 1) (1995) 714-718
46. Ding Z.Q., Rowe J., Ng B., Sinosich M.J., and Gallery E.D. Modulation of prostacyclin and thromboxane secretion by cytotrophoblasts from normal and pre-eclamptic human pregnancies. Placenta 23 8-9 (2002) 594-599
47. Blumenstein M., Keelan J.A., and Mitchell M.D. Hypoxia attenuates PGE(2)but increases prostacyclin and thromboxane production in human term villous trophoblast. Placenta 22 6 (2001) 519-525
48. Brennecke S.P., Gude N.M., Di Iulio J.L., and King R.G. Reduction of placental nitric oxide synthase activity in pre-eclampsia. Clin. Sci. (Lond.) 93 1 (1997) 51-55
49. Wang Y.P., Walsh S.W., Guo J.D., and Zhang J.Y. The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood. Am. J. Obstet. Gynecol. 165 6 (Pt 1) (1991) 1695-1700
50. Wang Y., Walsh S.W., and Kay H.H. Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia. Am. J. Obstet. Gynecol. 167 4 (Pt 1) (1992) 946-949
51. Ong S.S., Crocker I.P., Warren A.Y., and Baker P.N. Functional characteristics of chorionic plate placental arteries from normal pregnant women and women with pre-eclampsia. Hypertens. Pregnancy 21 3 (2002) 175-183