Fibroblast growth factor-specific modulation of cellular response by syndecan-4

Journal of Cell Biology

Volumn 157, Issue 4, 2002, Pages 715-725

  Horowitz, Arie ^a   Tkachenko, Eugene ^a   Simons, Michael ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

FGF; PDZ; PKC; Signal transduction; Syndecan 4

Indexed keywords

BINDING PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; PDZ PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN KINASE C ALPHA; PROTEOGLYCAN; SYNDECAN; SYNDECAN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CELL DENSITY; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME REGULATION; FIBROBLAST; GENE DISRUPTION; GENE MUTATION; GROWTH REGULATION; MEMBRANE BINDING; MOLECULAR MECHANICS; NONHUMAN; PHENOTYPE; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTORS; HUMANS; ISOENZYMES; MEMBRANE GLYCOPROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHORYLATION; POLYMERS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEOGLYCANS; SIGNAL TRANSDUCTION; SYNDECAN-4;

ANIMALIA;

EID: 0037071542     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200112145     Document Type: Article

References (45)

1. Syndecan-1 is required for wnt-1-induced mammary tumorigenesis in mice
2. Protein kinase C regulates the recruitment of syndecan-4 into focal contacts
3. Functions of cell surface heparan sulfate proteoglycans
4. Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression
5. Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-I protein kinase
6. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells
7. Delayed wound repair and impaired angio-genesis in mice lacking syndecan-4
8. Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons
9. Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines
10. Binding of neo-mycin to phosphatidylinositol 4,5-bisphosphate (PIP2)
11. Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds
12. Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration
13. ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex
14. Syntenin, a PDZ protein that binds syndecan cytoplasmic domains
15. Enhancement of migration by protein kinase Calpha and inhibition of proliferation and cell cycle progression by protein kinase Cdelta in capillary endothelial cells
16. Versatile retroviral vectors for potential use in gene therapy
17. Phosphorylation of the cytoplasmic tail of syndecan-4 regulates activation of protein kinase Calpha
18. Regulation of syndecan-4 phosphorylation in vivo
19. Phosphatidylinositol-4,5-bisphosphate mediates the interaction of syndecan-4 with protein kinase C
20. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain
21. Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses
22. Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions
23. Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment
24. Cell surface syndecan-1 on distinct cell types differs in fine structure and ligand binding of its heparan sulfate chains
25. Molecular cloning and expression of two distinct cDNA-encoding heparan sulfate proteoglycan core proteins from a rat endothelial cell line
26. Protein kinase C alpha activates RAF-1 by direct phosphorylation
27. Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding
28. Activation of IkappaB kinase beta by protein kinase C isoforms
29. Solution structure of a syndecan-4 cytoplasmic domain and its interaction with phosphatidylinositol 4,5-bisphosphate
30. Macrophage-dependent regulation of syndecan gene expression
31. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976
32. Characterization ofa cis-Golgi matrix protein, GM130
33. Smooth muscle cell expression of extracellular matrix genes after arterial injury
34. Multimerization of the cytoplasmic domain of syndecan-4 is required for its ability to activate protein kinase C
35. Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C
36. Syndecan-4 proteoglycan cytoplasmic domain and phosphatidylinositol 4,5-bis-phosphate coordinately regulate protein kinase C activity
37. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation
38. Activation of the mitogen-activated protein kinase/extracellular signal -regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
39. Characterization of ryudocan glycosaminoglycan acceptor sites
40. Syndecan-4-mediated signalling
41. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
42. Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells
43. The role of syndecan cytoplasmic domain in basic fibroblast growth factor-dependent signal transduction
44. Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo
45. Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component