Gd-DTPA L-cystine bisamide copolymers as novel biodegradable macromolecular contrast agents for MR blood pool imaging

Pharmaceutical Research

Volumn 23, Issue 6, 2006, Pages 1285-1294

  Kaneshiro, Todd L ^a   Ke, Tianyi ^a   Jeong, Eun Kee ^b   Parker, Dennis L ^b   Lu, Zheng Rong ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Biodegradable macromolecular contrast agent; Blood pool imaging; Gd DTPA L cystine bisamide copolymers; Magnetic resonance imaging; Polydisulfide

Indexed keywords

CHELATE; CONTRAST MEDIUM; DISULFIDE; GADOLINIUM PENTETATE; GADOLINIUM PENTETATE CYSTINE BISAMIDE COPOLYMER; GADOLINIUM PENTETATE CYSTINE BISISOPROPYL COPOLYMER; GADOLINIUM PENTETATE CYSTINE BISPROPYL AMIDE COPOLYMER; PENTETIC ACID; THIOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIODEGRADABILITY; BLOOD POOL SCINTISCANNING; COMPLEX FORMATION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DEVICE; DISULFIDE BOND; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MACROMOLECULE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERIZATION; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY; URINE;

ANIMALS; BIODEGRADATION, ENVIRONMENTAL; BLOOD VESSELS; CONTRAST MEDIA; CYSTINE; DRUG STABILITY; KIDNEY; LIVER; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE IMAGING; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PENTETIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33745400072     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-0024-0     Document Type: Article

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