Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole

Veterinary Anaesthesia and Analgesia

Volumn 33, Issue 4, 2006, Pages 214-223

  Granholm, Mikael ^a,b   McKusick, Brett C ^a   Westerholm, Fia C ^a   Aspegrén, John C ^a  

^a ORION CORPORATION   (Finland)

^b Veterinary Clinic Vettori Ltd   (Finland)

Author keywords

Analgesia; Cat; Clinical trial; Dexmedetomidine; Medetomidine; Sedation

Indexed keywords

ANIMALIA;

EID: 33745399101     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.2005.00259.x     Document Type: Article

References (21)

1. 2-adrenergic agonist. A review of its pharmacodynamic characteristics. Drugs of the Future 18, 49 56.
2. Ansah OB Raekallio M Vainio O ( 1998) Comparison of three doses of dexmedetomidine with medetomidine in cats following intramuscular administration. J Vet Pharmacol Ther 21, 380 387.
3. Ansah OB Raekallio M Vainio O ( 2000) Correlation between serum concentrations following continuous intravenous infusion of dexmedetomidine or medetomidine in cats and their sedative and analgesic effects. J Vet Pharmacol Ther 23, 1 8.
4. Cullen LK ( 1996) Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose. Br Vet J 152, 519 535.
5. 2 adrenoceptor agonists and anaesthesia. Br J Anaesth 71, 108 118.
6. 2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells. Eur J Pharmacol 266, 165 174.
7. 2A-adrenoceptors. Mol Pharmacol 53, 963 968.
8. Kuusela E Raekallio M Anttila M et al. ( 2000) Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs. J Vet Pharmacol Ther 23, 15 20.
9. Kuusela E Vainio O Kaistinen A et al. ( 2001) Sedative, analgesic, and cardiovascular effects of levomedetomidine alone and in combination with dexmedetomidine in dogs. Am J Vet Res 62, 616 621.
10. Lamont LA Bulmer BJ Grimm KA et al. ( 2001) Cardiopulmonary evaluation of the use of medetomidine hydrochloride in cats. Am J Vet Res 62, 1745 1749.
11. MacDonald E Scheinin H Scheinin M ( 1988) Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative. Eur J Pharmacol 158, 119 127.
12. Mendes GM Selmi AL Barbudo-Selmi GR et al. ( 2003) Clinical use of dexmedetomidine as premedicant in cats undergoing propofol-sevoflurane anaesthesia. J Feline Med Surg 5, 265 270.
13. Ruffolo RR ( 1985) Distribution and function of peripheral alpha-adrenoceptors in the cardiovascular system. Pharmacol Biochem Behav 22, 827 833.
14. Savola J-M Virtanen R ( 1991) Central alpha-2 adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. Eur J Pharmacol 195, 193 199.
15. Selmi AL Mendes GM Lins BT et al. ( 2003) Evaluation of the sedative and cardiorespiratory effects of dexmedetomidine, dexmedetomidine-butorphanol, and dexmedetomidine-ketamine in cats. J Am Vet Med Assoc 222, 37 41.
16. Stenberg D Salven P Miettinen MV ( 1987) Sedative action of the alpha 2-agonist medetomidine in cats. J Vet Pharmacol Ther 10, 319 323.
17. Stenberg D Porkka-Heiskanen T Toppila J ( 1993) Alpha 2-adrenoceptors and vigilance in cats: antagonism of medetomidine sedation by atipamezole. Eur J Pharmacol 238, 241 247.
18. Vähä-Vahe T ( 1989) Clinical evaluation of medetomidine, a novel sedative and analgesic drug for dogs and cats. Acta Vet Scand 30, 267 273.
19. Vainio O ( 1989) Introduction to the clinical pharmacology of medetomidine. Acta Vet Scand Suppl 85, 151 153.
20. 2-adrenergic agonist, in halothane-anesthetized dogs. Anesth Analg 67, 611 615.
21. Virtanen R Savola JM Saano V et al. ( 1988) Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 150, 9 14.