Optimizing hCG cut-off values: A single determination on day 14 or 15 is sufficient for a reliable prediction of pregnancy outcome

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 127, Issue 1, 2006, Pages 94-98

  Lambers, Marieke J ^a   van Weering, Hans G I ^a   van't Grunewold, Maud S ^a   Lambalk, Cornelis B ^a   Homburg, Roy ^a   Schats, Roel ^a   Hompes, Peter G A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ART; Cut off levels; hCG; Pregnancy; Retrospective

Indexed keywords

CHORIONIC GONADOTROPIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FERTILIZATION IN VITRO; HORMONE BLOOD LEVEL; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; OOCYTE; OVULATION; PREDICTION; PREGNANCY OUTCOME; PRIORITY JOURNAL; RELIABILITY;

EID: 33745360668     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2005.12.023     Document Type: Article

References (40)

1. Aschheim S., and Zondeck B. Hypophysenvorderlappenhormon und Ovarialhormon im Harn von Schwangern. Klin Wochenschr 6 (1927) 1322
2. Braunstein G.D., Grodin J.M., Vaitukaitis J., and Ross G.T. Secretory rates of human chorionic gonadotropin by normal trophoblast. Am J Obstet Gynecol 115 4 (1973) 447-450
3. Braunstein G.D. False-positive serum human chorionic gonadotropin results: causes, characteristics, and recognition. Am J Obstet Gynecol 187 1 (2002) 217-224
4. Batzer F.R., Schlaff S., Goldfarb A.F., and Corson S.L. Serial beta-subunit human chorionic gonadotropin doubling time as a prognosticator of pregnancy outcome in an infertile population. Fertil Steril 35 3 (1981) 307-312
5. Kadar N., Freedman M., and Zacher M. Further observations on the doubling time of human chorionic gonadotropin in early asymptomatic pregnancies. Fertil Steril 54 5 (1990) 783-787
6. Fridstrom M., Garoff L., Sjoblom P., and Hillensjo T. Human chorionic gonadotropin patterns in early pregnancy after assisted reproduction. Acta Obstet Gynecol Scand 74 7 (1995) 534-538
7. Homan G., Brown S., Moran J., Homan S., and Kerin J. Human chorionic gonadotropin as a predictor of outcome in assisted reproductive technology pregnancies. Fertil Steril 73 2 (2000) 270-274
8. Heiner J.S., Kerin J.F., Schmidt L.L., and Wu T.C. Can a single, early quantitative human chorionic gonadotropin measurement in an in vitro fertilization-gamete intrafallopian transfer program predict pregnancy outcome?. Fertil Steril 58 2 (1992) 373-377
9. Carmona F., Balasch J., Creus M., et al. Early hormonal markers of pregnancy outcome after in vitro fertilization and embryo transfer. J Assist Reprod Genet 20 12 (2003) 521-526
10. Sereepapong W., Suwajanakorn S., Pruksananonda K., Boonkasemsanti W., and Virutamasen P. Predictive value of human chorionic gonadotropin in the outcome of early pregnancy achieved by assisted reproductive technology. J Med Assoc Thai 85 Suppl. 1 (2002) S447-S454
11. Guth B., Hudelson J., Higbie J., et al. Predictive value of hCG level 14 days after embryo transfer. J Assist Reprod Genet 12 1 (1995) 13-14
12. Qasim S.M., Callan C., and Choe J.K. The predictive value of an initial serum beta human chorionic gonadotropin level for pregnancy outcome following in vitro fertilization. J Assist Reprod Genet 13 9 (1996) 705-708
13. Schmidt L.L., Asch R.H., Frederick J.L., Rojas F.J., Stone S.C., and Balmaceda J.P. The predictive value of a single beta human chorionic gonadotropin in pregnancies achieved by assisted reproductive technology. Fertil Steril 62 2 (1994) 333-338
14. Glatstein I.Z., Hornstein M.D., Kahana M.J., Jackson K.V., and Friedman A.J. The predictive value of discriminatory human chorionic gonadotropin levels in the diagnosis of implantation outcome in in vitro fertilization cycles. Fertil Steril 63 2 (1995) 350-356
15. Bjercke S., Tanbo T., Dale P.O., Morkrid L., and Abyholm T. Human chorionic gonadotrophin concentrations in early pregnancy after in vitro fertilization. Hum Reprod 14 6 (1999) 1642-1646
16. Chen C.D., Ho H.N., Wu M.Y., Chao K.H., Chen S.U., and Yang Y.S. Paired human chorionic gonadotrophin determinations for the prediction of pregnancy outcome in assisted reproduction. Hum Reprod 12 11 (1997) 2538-2541
17. Poikkeus P., Hiilesmaa V., and Tiitinen A. Serum hCG 12 days after embryo transfer in predicting pregnancy outcome. Hum Reprod 17 7 (2002) 1901-1905
18. Papageorgiou T.C., Leondires M.P., Miller B.T., et al. Human chorionic gonadotropin levels after blastocyst transfer are highly predictive of pregnancy outcome. Fertil Steril 76 5 (2001) 981-987
19. Urbancsek J., Hauzman E., Fedorcsak P., Halmos A., Devenyi N., and Papp Z. Serum human chorionic gonadotropin measurements may predict pregnancy outcome and multiple gestation after in vitro fertilization. Fertil Steril 78 3 (2002) 540-542
20. Sugantha S.E., Webster S., Sundar E., and Lenton E.A. Predictive value of plasma human chorionic gonadotrophin following assisted conception treatment. Hum Reprod 15 2 (2000) 469-473
21. Altman D. Practical statistics for medical research (1999), Chapman and Hall, London
22. Pittaway D.E., and Wentz A.C. Evaluation of early pregnancy by serial chorionic gonadotropin determinations: a comparison of methods by receiver operating characteristic curve analysis. Fertil Steril 43 4 (1985) 529-533
23. Isaacs J.D., Whitworth N.S., and Cowan B.D. Relative operating characteristic analysis in reproductive medicine: comparison of progesterone and human chorionic gonadotropin doubling time as predictors of early gestational normalcy. Fertil Steril 62 3 (1994) 452-455
24. Long C.A., Lincoln S.R., Whitworth N.S., and Cowan B.D. Progesterone concentration as a predictor of pregnancy normalcy is the most useful when hCG levels are less than 2000 mIU/mL. J Assist Reprod Genet 12 3 (1995) 195-197
25. Yamashita T., Okamoto S., Thomas A., MacLachlan V., and Healy D.L. Predicting pregnancy outcome after in vitro fertilization and embryo transfer using estradiol, progesterone, and human chorionic gonadotropin beta-subunit. Fertil Steril 51 2 (1989) 304-309
26. Hauzman E., Fedorcsak P., Klinga K., et al. Use of serum inhibin A and human chorionic gonadotropin measurements to predict the outcome of in vitro fertilization pregnancies. Fertil Steril 81 1 (2004) 66-72
27. Treetampinich C., O'Connor A.E., MacLachlan V., Groome N.P., and de Kretser D.M. Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome. Hum Reprod 15 9 (2000) 2028-2032
28. Phipps M.G., Hogan J.W., Peipert J.F., Lambert-Messerlian G.M., Canick J.A., and Seifer D.B. Progesterone, inhibin, and hCG multiple marker strategy to differentiate viable from non-viable pregnancies. Obstet Gynecol 95 2 (2000) 227-231
29. Brandenberger A.W., Bersinger N.A., Huber P.R., Berger E., Glanzmann P., and Birkhaeuser M.H. CA-125 concentrations in the serum and pregnancy outcome in IVF cycles. J Assist Reprod Genet 15 6 (1998) 390-394
30. Fish K.E., Phipps M., Trimarchi J., Weitzen S., and Blazar A.S. CA-125 serum levels and pregnancy outcome in in vitro fertilization. Fertil Steril 82 6 (2004) 1705-1707
31. Fujiwara H., Motoyama M., Shibahara H., Koike T., Ogawa S., and Suzuki M. Predictive value of urine human chorionic gonadotropin after assisted reproductive technology. Fertil Steril 80 4 (2003) 1055-1057
32. O'Connor J.F., Ellish N., Kakuma T., Schlatterer J., and Kovalevskaya G. Differential urinary gonadotrophin profiles in early pregnancy and early pregnancy loss. Prenat Diagn 18 12 (1998) 1232-1240
33. Lohstroh P.N., Overstreet J.W., Stewart D.R., et al. Secretion and excretion of human chorionic gonadotropin during early pregnancy. Fertil Steril 83 4 (2005) 1000-1011
34. Mock P., Kovalevskaya G., O'Connor J.F., and Campana A. Choriocarcinoma-like human chorionic gonadotrophin (hCG) and hCG bioactivity during the first trimester of pregnancy. Hum Reprod 15 10 (2000) 2209-2214
35. Kovalevskaya G., Birken S., Kakuma T., and O'Connor J.F. Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. J Endocrinol 161 1 (1999) 99-106
36. Mannaerts B.M., Geurts T.B., and Odink J. A randomized three-way cross-over study in healthy pituitary-suppressed women to compare the bioavailability of human chorionic gonadotrophin (Pregnyl) after intramuscular and subcutaneous administration. Hum Reprod 13 6 (1998) 1461-1464
37. Lenton E.A., Neal L.M., and Sulaiman R. Plasma concentrations of human chorionic gonadotropin from the time of implantation until the second week of pregnancy. Fertil Steril 37 6 (1982) 773-778
38. Pittaway D.E., Reish R.L., and Wentz A.C. Doubling times of human chorionic gonadotropin increase in early viable intrauterine pregnancies. Am J Obstet Gynecol 152 3 (1985) 299-302
39. Alahakoon T.I., Crittenden J., and Illingworth P. Value of single and paired serum human chorionic gonadotropin measurements in predicting outcome of in vitro fertilization pregnancy. Aust N Z J Obstet Gynaecol 44 1 (2004) 57-61
40. Hauzman E., Fedorcsak P., Halmos A., et al. Role of serum hCG measurements in predicting pregnancy outcome and multiple gestation after in vitro fertilization. Early Pregnancy 5 1 (2001) 26-27