Megalin/gp330 mediates uptake of albumin in renal proximal tubule

American Journal of Physiology

Volumn 271, Issue 4 PART 2, 1996, Pages

  Gui, Shiying ^a   Verrohst, Pierre J ^a   Moestrup, Soren K ^a   Christensen, Erik Ilso ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Endocytosis; Kidney; Lysosomes; Receptors

Indexed keywords

EID: 33745328902     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Bachinsky, D. R., G. Zheng, J. L. Niles, M. McLaughlin, M. Abbate, G. Andres, D. Brown, and R. T. McCluskey. Detection of two- forms of GP330. Their role in Heymann nephritis. Am. J. Pathol. 143: 598-611, 1993.
2. Bourdeau, J. E., F. A. Carone, and C. E. Ganote. Serum albumin uptake in isolated perfused renal tubules. J. Cell Biol. 54: 382-398,1972.
3. Bu, G., H. J. Geuze, G. J. Strous, and A. L. Schwartz. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. EMBO J. 14: 2269-2280,1995.
4. Chatelet, F., E. Brianti, P. Ronco, J. Roland, and P. Verroust. Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution. Am. J. Pathol. 122: 500-511,1986.
5. Chen, W. J., J. L. Goldstein, and M. S. Brown. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J. Biol. Chem. 265: 3116-3123,1990.
6. Christensen, E. I. Rapid protein uptake and digestion in proximal tubule lysosomes. Kidney Int. 10: 301-310,1976.
7. Christensen, E. I. Rapid membrane recycling in renal proximal tubule cells. Eur. J. Cell Biol. 29: 43-49,1982.
8. Christensen, E. I., F. A. Carone, and H. G. Rennke. Effect of molecular charge on endocytic uptake of ferritin in renal proximal tubule cells. Lab. Invest. 44: 351-358,1981.
9. Christensen, E. I., J. Gliemann, and S. K. Moestrup. Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein. J. Histochem. Cytochem. 40:1481-1490,1992.
10. Christensen, E. I., and S. Nielsen. Structural and functional features of protein handling in the kidney proximal tubule. Semin. Nephrol. 11: 414-439,1991.
11. Christensen, E. I., S. Nielsen, S. K. Moestrup, C. Borre, A. B. Ma unsbach, E. De Heer, P. Ronco, T. G. Hammond, and P. Verroust. Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. Eur. J. Cell Biol. 66: 349-364,1995.
12. Christensen, E. I., H. G. Rennke, and F. A. Carone. Renal tubular uptake of protein: effect of molecular charge. Am. J. Physiol. 244 (Renal Fluid Electrolyte Physiol. 13): F436-F441, 1983.
13. Cui, S., and E. I. Christensen. Three-dimensional organization of the vacuolar apparatus involved in endocytosis and membrane recycling of rat kidney proximal tubule cells. An electronmicroscopic study of serial sections. Exp. Nephrol. 1: 175-184, 1993.
14. Kerjaschki, D., and M. G. Farquhar. The pathogenic antigen of Heyma.nn nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc. Natl. Acad. Sci. USA 79: 5557-5561,1982.
15. Kerjaschki, D., L. Noronha-Blob, B. Sacktor, and M. G. Farquhatr. Microdomains of distinctive glycoprotein composition in the kidney proximal tubule brush border. J. Cell Biol. 98: 1505-1513,1984.
16. Kounnas, M. Z., W. S. Argraves, and D. K. Strickland. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. J. Biol. Chem. 267: 2116221166,1992.
17. Maack, T., C. H. Park, and M. J. F. Camargo. Renal filtration, transport and metabolism of proteins. In: The Kidney: Physiology and Pathophysiology, edited by D. W. Seldin and G. Giebisch. New York: Raven, 1992, p. 3005-3038.
18. Maunsbach, A. B. Absorption of I125-labeled homologous albumin by rat kidney proximal tubule cells. A study of microperfused single proximal tubules by electron microscopic autoradiography and histochemistry. J. Ultrastruct. Res. 15: 197-241,1966.
19. Maunsbach, A. B., and E. I. Christensen. Functional ultrastructure of the proximal tubule. In: Handbook of Physiology. Renal Physiology. Bethesda, MD: Am. Physiol. Soc., 1992, vol. I, sect. 8, chapt. 2, p. 41-107.
20. Moestrup, S. K., S. Cui, H. Vorum, C. Bregengard, S. E. Bj0rn, K. Norris, J. Gliemann, and E. I. Christensen. Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J. Clin. Invest. 96: 1404-1413, 1995.
21. Moestrup, S. K., S. Nielsen, P. Andreasen, K. E. Jorgensen, A. Nykjaer, H. Roigaard, J. Gliemann, and E. I. Christensen. Epithelial glycoprotein-330 mediates endocytosis of plasminogen aetivator-plasminogen activator inhibitor type-1 complexes. J. Biol. Chem. 268:16564-16570,1993.
22. Nykjaer, A., C. M. Petersen, B. Moller, P. H. Jensen, S. K. Moestrup, T. L. Holtet, M. Etzerodt, H. C. Th0gersen, M. Munch, P. A. Andreasen, and J. Gliemann. Purified a2macroglobulin receptor/LDL receptor-related protein binds urokinase plasminogen activator inhibitor type-1 complex. Evidence that the a2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J. Biol. Chem. 267: 24543-24546,1992.
23. Orlando, R. A., K. Rader, F. Authier, J. J. Bergeron, and M. G. Farquhar. Role of megalin(gp330) in binding low molecular weight proteins in the renal nitrate (Abstract). J. Am. Soc. Nephrol. 6: 378,1995.
24. Orlando, R. A., D. Kerjaschki, H. Kurihara, 10. Biemesderfer, and M. G. Farquhar. gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc. Natl. Acad. Sci. USA 89: 6698-6702, 1992.
25. Park, C. H., and T. Maack. Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit. J. Clin. Invest. 73: 767-777,1984.
26. Raychowdhury, R., J. L. Niles, R. T. McCluskey, and J. A. Smith. Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor. Science Wash. DC 244: 1163-1165,1989.
27. Rosenberg, M. E., and T. H. Hostetter. Proteinuria. In: The Kidney: Physiology and Pathophysiology, edited by D. W. Scidin and G. Giebisch. New York: Raven, 1992, p. 3039-3061.
28. Sahali, D., N. Mulliez, F. Chatelet, C. Laurent-Winter, D. Citadelle, J.-C. Sabourin, C. Roux, P. Ronco, P. J. Verroust. Comparative immunochemistry and ontogeny of two closely related coated pit proteins. The 280-kd target of teratogenic antibodies and the 330-kd target of nephritogenic antibodies. Am. J. Pathol 142: 1654-1667, 1993.
29. Saito, A., S. Pietromonaco, A. K. Loo, and M. G. Farquhar. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc. Natl. Acad. Sci. USA 91: 9725-9729,1994.
30. Schwegler, J. S., B. Heppelmann, S. Mildenberger, and S. Silbernagl. Receptor-mediated endocytosis of albumin in cultured opossum kidney cells: a model for proximal tubular protein reabsorption. Pfluegers Arch. 418: 383-392,1991.
31. Tisher, C. C., and J. P. Kokko. Relationship between peritubular oncotic pressure gradients and morphology in isolated proximal tubules. Kidney Int. 6:146-156,1974.
32. Willnow, T. E., S. A. Armstrong, R. E. Hammer, and J. Herz. Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc. Natl. Acad. Sci. USA 92: 4537-4541,1995.
33. Willnow, T. E., J. L. Goldstein, K. Orth, M. S. Brown, and J. Herz. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activatorinhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J. Biol. Chem. 267: 26172-26180,1992.