Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs

Journal of Clinical Investigation

Volumn 96, Issue 3, 1995, Pages 1404-1413

  Moestrup, Søren Kragh ^a   Cui, Shiying ^a   Vorum, Henrik ^a   Bregengård, Claus ^b   Bjørn, Søren Erik ^b   Norris, Kjeld ^b   Gliemann, Jørgen ^a   Christensen, Erik Ilsø ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

aminoglycosides; endocytosis; glycoprotein 330; kidney; low density lipoprotein receptor related protein

Indexed keywords

ALPHA 2 MACROGLOBULIN; AMIKACIN; APROTININ; GENTAMICIN; GLYCOPROTEIN; MEGALIN; NETILMICIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMYXIN B; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG UPTAKE; ENDOCYTOSIS; FEMALE; GLOMERULUS FILTRATION; KIDNEY PROXIMAL TUBULE; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SACCHAROMYCES CEREVISIAE;

EID: 0029151692     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118176     Document Type: Article

References (59)

1. Kerjaschki, D., and M. G. Farquhar, M. G. 1982. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc. Natl. Acad. Sci. USA. 79:5557-5561.
2. Saito, A., S. Pietromonaco, A. K.-C. Loo, and M. G. Farquhar. 1994. Complete cloning and sequencing of rat gp330/'megalin', a distinctive member of the low density lipoprotein receptor gene family. Proc. Natl. Acad. Sci. USA. 91:9725-9729.
3. Makker, S. P., and A. K. Singh. 1984. Characterization of the antigen (gp600) of Heymann Nephritis. Lab. Invest. 50:287-293.
4. Christensen, E. I., J. Gliemann, and S. K. Moestrup. 1992. Renal tubule glycoprotein 330 is a calcium-binding receptor mediating endocytosis of protein. J. Histochem. Cytochem. 40:1481-1490.
5. Willnow, T. E., J. L. Goldstein, K. Orth, M. S. Brown, and J. Herz. 1992. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J. Biol. Chem. 267:26172-26180.
6. 2-macroglobulin receptor and glycoprotein 330. J. Biol. Chem. 267:21162-21166.
7. Chatelet, F., E. Brianti, P. Ronco, J. Roland, and P. Verroust. 1986. Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. II. Extrarenal distribution. Am. J. Pathol. 122:512-519.
8. Zheng, G., D. R. Bachinsky, I. Stamekovic, D. K. Strickland, D. Brown, G. Andres, and R. T. McCluskey. 1994. Organ distribuion in rats of two members of the low density lipoprotein receptor gene family, gp330 and LRP/α2MR, and the receptor-associated protein (RAP). J. Histochem. Cytochem. 42:531-542.
9. Kounnas, M. Z., C. C. Haudenschild, D. K. Strickland, and W. S. Argraves. 1994. Immunological localization of glycoprotein 330. low density lipoprotein receptor-related protein and 39 kDa receptor-associated protein in mouse embryonic tissues In Vivo (Athens). 8:343-351.
10. Raychowdhury, R., J. L. Niles, R. T. McCluskey, and J. A. Smith. 1989. Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor. Science (Wash. DC). 244:1163-1165.
11. 2-macroglobulin receptor and glycoprotein 330. Two giant receptors mediating endocytosis of multiple ligands. Biochim. Biophys. Acta. 1197:197-213.
12. Krieger, M. and J. Herz. 1994. Structures and functions of multiligand receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 63:601-637.
13. Makker, S. P. 1993. Analysis of glomeruli-eluted gp330 autoantibodies and of gp330 antigen of Heymann Nephritis. J. Immunol. 151:6500-6508.
14. 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res. 269:375-382.
15. 2-macroglobulin receptor contains high affinity calcium binding sites important for receptor conformation and ligand recognition. J. Biol. Chem. 265:12623-12628.
16. Orlando, R. A., D. Kerjaschki, H. Kurihara, D. Biemesderfer, and M. G. Farquhar. 1992. Gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc. Natl. Acad. Sci. USA. 89:6698-6702.
17. Kanalas, J. J., and S. P. Makker. 1991. Identification of rat Heymann Nephritis autoantigen as a receptor site for plasminogen. J. Biol. Chem. 266:10825-10829.
18. 2-macroglobulin receptor containing a cluster of eight complement-type repeats. J. Biol. Chem. 268:13691-13696.
19. Willnow, T. E., K. Orth, and J. Herz. 1994. Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein. J. Biol. Chem. 269:15827-15837.
20. Moestrup, S. K., S. Nielsen, P. A. Andreasen, K. E. Jørgensen, A. Nykjær, H. Røigaard, J. Gliemann, and E. I. Christensen. 1993. Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator type-1 complexes. J. Biol. Chem. 268:16564-16570.
21. Lundgren, S., G. Hjälm, P. Hellman, B. Ek, C. Juhlin, J. Rastad, L. Klareskog, G. Åkerstrøm, and L. Rask. 1994. A protein involved in the calcium sensing of the human parathyroid, placenta and kidney tubule cells belongs to the LDL-receptor protein superfamily. Exp. Cell Res. 212:344-350.
22. de Groot, J. C., F. Meeuwsen, W. E. Ruizendaal, and J. E. Veldman. 1990. Ultrastructural localization of gentamicin in clochlea. Hear. Res. 50:35-42.
23. Morin, J. P., G. Viotte, A. Vanderwalle, F. Vanhoof, P. Tulkens, and J. P. Fillastre. 1988. Gentamicin-induced nephrotoxicity: a cell biology approach. Kidney Int. 18:583-590.
24. Silverblatt, F. J., and C. Kuehn. 1983. Autoradiography of gentamicin uptake by the rat proximal tubule cell. Lab. Invest. 48:212-223.
25. Humes, H. D. 1988. Aminoglycoside nephrotoxicity. Kidney Int. 22:900-911.
26. Molitoris, B. A., C. Meyer, R. Dahl, and A. Geerdes. 1993. Mechanism of ischemia-enhanced aminoglycosides binding and uptake by proximale tubule cells. Am. J. Physiol. 264:F907-F916.
27. Houghton, D. C., M. Hartnett, M. Campbell-Boswell, G. Porter, and W. Bennet. 1976. Chronic gentamicin nephrotoxicity. Am. J. Pathol. 82:589-612.
28. Wedeen, R. P., V. Batuman, C. Cheeks, E. Marquet, and H. Sobel. 1983. Transport of gentamicin in the rat proximal tubule. Lab. Invest. 48:212-223.
29. Tran-Ba-Huy, P., P. Bernard, and J. Schacht. 1986. Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs. J. Clin. Invest. 77:1492-500.
30. Just, M., G. Erdmann, and E. Habermann. 1977. The renal handling of polybasic drugs. 1. Gentamicin and aprotinin in intact animals. Arch. Pharmacol. 300:57-66.
31. Just, M. and E. Habermann. 1977. The renal handling of polybasic drugs 2. In vitro studies with brush border and lysosomal fractions. Arch. Pharmacol. 300:67-76.
32. Creighton, T. E. 1975. The two disulphide intermediates and the folding pathway of reduced pancreatic trypsin inhibitor. J. Mol. Biol. 95:167-199.
33. Bergen, T., and J. Fuglsang. 1982. Polymyxin antibiotics. Antibiot. Chemother. (Wash. DC). 31:119-144.
34. Sande, M. A., and G. L. Mandell. 1990. Antimicrobial agents. In Goodman and Gilmann's The Pharmalogical Basis of Therapeutics. A. G. Gilman, T. W. Rall, A. S. Nies, and P. Taylor editors, Pergamon Press Inc., New York. 1117-1148.
35. Morrison, D. C. and D. M. Jacobs. 1978. Binding of polymyxin B to lipid A portion of bacterial lipopolysaccharides. Immunochemistry. 3:813-818.
36. 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J. Biol. Chem. 267:14543-14546.
37. Norris, K., F. Norris, S. E. Bjørn, I. Diers, and L. C. Petersen. 1990. Aprotinin and aprotinin analogues expression in yeast. Biol. Chem. Hoppe-Seyler. 371:37-42.
38. 2-macroglobulin complexes in rat hepatocytes. Biochem. Biophys. Acta. 885:49-57.
39. Brodersen, R., S. Andersen, C. Jacobsen, O. Sønderskov, F. Ebbesen, W. J. Cashore, and S. Larsen. 1982. Determination of the reserve albumin-equivalent for ligand binding, probing two distinct binding functions fo the protein. Anal. Biochem. 121:395-408.
40. Bradford, M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 72:248-254.
41. 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor associated protein. J. Biol. Chem. 267:9035-9040.
42. Orlando, R. A., and M. G. Farquhar. 1993. Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann Nephritis antigenic complex. Proc. Natl. Acad. Sci. USA. 90:4082-4086.
43. Moestrup, S. K., E. I. Christensen, S. Nielsen, K. E. Jørgensen, S. E. Bjørn, H. Røigaard, and J. Gliemann. 1994. Binding and endocytosis of proteins mediated by epithelial gp330. Ann. NY Acad. Sci. 737:124-138.
44. Christensen, E. I., F. A. Carone, and H. G. Reenke. 1981. Effect of molecular charge on endocytic uptake of ferritin in renal proximal tubule cells. Lab. Invest. 44:351-358.
45. Christensen, E. I., H. G. Rennke, and F. A. Carone. 1983. Renal tubular uptake of protein: Effect of molecular charge. Am. J. Physiol. F436-F441.
46. Maunsbach, A. B., and E. I. Christensen. 1992. Functional ultrastructure of the proximal tubule. In Handbook of Physiology. Renal Physiology. Section 8. E. E. Windhager, editor Oxford University Press, New York. 41-107.
47. Satrasinh, M., T. C. Knauss, J. M. Weinberg, and H. D. Humes. 1982. Identification of the aminoglycoside binding site in rat renal brush border membrane. J. Pharmacol. Exp. Ther. 222:350-358.
48. Humes, H. D., M. Satrasinh, and J. M. Weinberg. 1984. Calcium is a competitive inhibitor of gentamicin renal binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity. J. Clin. Invest. 73:134-147.
49. 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and β-migrating low density lipoprotein associated with lipase. J. Biol. Chem. 268:15048-15055.
50. Chapell, D. A., G. L. Fry, M. A. Waknitz, L. E. Muhonen, M. W. Pladet, P.-H. Iverius, and D. K. Strickland. 1993. Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor-related protein/in vitro. A process fascilitated by cell surface proteoglycans. J. Biol. Chem. 268:14168-14175.
51. Christensen, E. I., S. Nielsen, S. K. Moestrup, C. Borre, A. B. Maunsbach, E. De Heer, T. G. Hammond, and P. Verroust. 1995. Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. Eur. J. Cell Biol. 66:349-364.
52. Aubert-Tulkens, G., F. Van Hoof, and P. Tulkens. 1979. Gentamicin-induced lysosomal phopholipodosis in cultured rat fibroblasts: a quantitative ultrastructural and biochemical study. Lab. Invest. 40:481-493.
53. D'Amico, D. J., J. Libert, K. R. Kenyon, L. A. Hannien, and L. Caspers-Vehi. 1985. Retinal toxicity of intraretinal gentamicin. An electron microscopic study IOVS. (Invest. Ophthalmol. & Visual Sci.) 25:564-572.
54. Hayashida, T., Y. Nomura, M. Iwamori, Y. Nagai, and T. Kurata. 1985. Distribution of gentamicin by immunofluorescence in the guinea pig inner ear. Arch. Otorhinolaryngol. 242:257-264.
55. 2-macroglobulin receptor in human fibroblasts. Abscent in tumor-derived cell lines. J. Biol. Chem. 254:5155-5160.
56. Warshawsky, I., G. J. Broze, and A. L. Schwartz. 1994. The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor. Proc. Natl. Acad. Sci. USA. 91:6664-6668.
57. Bysani, G. K., D. C. Stokes, M. Fishman, J. L. Shenep, W. K. Hildner, K. Rufus, N. Bradham, and M. E. Costlow. 1990. Binding of polymyxin B to rat alveolar macrophages. J. Infect. Dis. 162:939-942.
58. Liao, W., and C.-H. Floren. 1993. Polymyxin B complexes with and cationizes low density lipoproteins. Biochem. Pharmacol 45:1835-1843.
59. Liao, W. and C.-H. Floren. 1992. Polymyxin B enhances low density lipoprotein catabolism in hepatic and extrahepatic cells. Arterioscler. and Thromb. 12:503-511.