메뉴 건너뛰기




Volumn 55, Issue 5, 2006, Pages 1369-1379

Activation of glucagon-like peptide-1 receptor signaling does not modify the growth or apoptosis of human pancreatic cancer cells

Author keywords

BrdU, 5 bromo 2 deoxyuridine; CREB, cAMP responsive element binding protein; DMEM, Dulbecco's modified Eagle's medium; EGF, epidermal growth factor; EGFR, EGF receptor; ERK, extracellular regulated kinase; Ex 4, exendin 4; FBS, fetal bovine serum

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ADENYLATE CYCLASE; BROXURIDINE; CHOLERA TOXIN; CYCLIC AMP; CYCLOHEXIMIDE; CYCLOPAMINE; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EXENDIN 4; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GLICENTIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 2; GLUCOSE; INDOMETACIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXYNTOMODULIN; PEPTIDE HORMONE; PROTEIN INHIBITOR; STREPTOZOCIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; CYCLOALKANE DERIVATIVE; ENZYME INHIBITOR; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR; MORPHOLINE DERIVATIVE;

EID: 33745320855     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1145     Document Type: Article
Times cited : (53)

References (42)
  • 1
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker DJ: Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 26:2929-2940, 2003
    • (2003) Diabetes Care , vol.26 , pp. 2929-2940
    • Drucker, D.J.1
  • 2
    • 0032701468 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential
    • Holst JJ: Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential. Curr Med Chem 6:1005-1017, 1999
    • (1999) Curr Med Chem , vol.6 , pp. 1005-1017
    • Holst, J.J.1
  • 3
    • 4344675057 scopus 로고    scopus 로고
    • Therapeutic strategies based on glucagon-like peptide 1
    • Deacon CF: Therapeutic strategies based on glucagon-like peptide 1. Diabetes 53:2181-2189, 2004
    • (2004) Diabetes , vol.53 , pp. 2181-2189
    • Deacon, C.F.1
  • 4
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S: Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276, 1999
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 5
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide-1 agonists stimulate expression of homeodomain protein IDX-1 and increase β-cell mass in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Egan JM, Bonner-Weir S, Habener JF: Insulinotropic glucagon-like peptide-1 agonists stimulate expression of homeodomain protein IDX-1 and increase β-cell mass in mouse pancreas. Diabetes 49:741-748, 2000
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Egan, J.M.5    Bonner-Weir, S.6    Habener, J.F.7
  • 7
    • 0037386156 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway
    • Hui H, Nourparvar A, Zhao X, Perfetti R: Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 144:1444-1455, 2003
    • (2003) Endocrinology , vol.144 , pp. 1444-1455
    • Hui, H.1    Nourparvar, A.2    Zhao, X.3    Perfetti, R.4
  • 8
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfetti R, Zhou J, Doyle ME, Egan JM: Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141:4600-4605, 2000
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 9
    • 0037414781 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
    • Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ: Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278:471-478, 2003
    • (2003) J Biol Chem , vol.278 , pp. 471-478
    • Li, Y.1    Hansotia, T.2    Yusta, B.3    Ris, F.4    Halban, P.A.5    Drucker, D.J.6
  • 10
    • 0037312829 scopus 로고    scopus 로고
    • Role of endogenous glucagon-like peptide-1 in islet regeneration following partial pancreatectomy
    • De Leon DD, Deng S, Madani R, Ahima RS, Drucker DJ, Stoffers DA: Role of endogenous glucagon-like peptide-1 in islet regeneration following partial pancreatectomy. Diabetes 52:365-371, 2003
    • (2003) Diabetes , vol.52 , pp. 365-371
    • De Leon, D.D.1    Deng, S.2    Madani, R.3    Ahima, R.S.4    Drucker, D.J.5    Stoffers, D.A.6
  • 11
    • 0037221488 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces pancreatic β-cell proliferation via transactivation of the epidermal growth factor receptor
    • Buteau J, Foisy S, Joly E, Prentki M: Glucagon-like peptide 1 induces pancreatic β-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 52:124-132, 2003
    • (2003) Diabetes , vol.52 , pp. 124-132
    • Buteau, J.1    Foisy, S.2    Joly, E.3    Prentki, M.4
  • 13
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J, Wang X, Pineyro MA, Egan JM: Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 48:2358-2366, 1999
    • (1999) Diabetes , vol.48 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3    Egan, J.M.4
  • 14
    • 0036326210 scopus 로고    scopus 로고
    • Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX-1 and HNF3beta transcription factors
    • Zhou J, Pineyro MA, Wang X, Doyle ME, Egan JM: Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors. J Cell Physiol 192:304-314, 2002
    • (2002) J Cell Physiol , vol.192 , pp. 304-314
    • Zhou, J.1    Pineyro, M.A.2    Wang, X.3    Doyle, M.E.4    Egan, J.M.5
  • 15
    • 0035084164 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells
    • Hui H, Wright C, Perfetti R: Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 50:785-796, 2001
    • (2001) Diabetes , vol.50 , pp. 785-796
    • Hui, H.1    Wright, C.2    Perfetti, R.3
  • 16
    • 0026775150 scopus 로고
    • Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1
    • Thorens B: Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci U S A 89:8641-8645, 1992
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 8641-8645
    • Thorens, B.1
  • 18
    • 0037312818 scopus 로고    scopus 로고
    • Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis
    • Drucker DJ: Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17:161-171, 2003
    • (2003) Mol Endocrinol , vol.17 , pp. 161-171
    • Drucker, D.J.1
  • 19
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy N, DePinho RA: Pancreatic cancer biology and genetics. Nat Rev Cancer 2:897-909, 2002
    • (2002) Nat Rev Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    DePinho, R.A.2
  • 21
    • 0020060077 scopus 로고
    • Human pancreatic adenocarcinoma line Capan-1 in tissue culture and the nude mouse: Morphologic, biologic, and biochemical characteristics
    • Kyriazis AP, Kyriazis AA, Scarpelli DG, Fogh J, Rao MS, Lepera R: Human pancreatic adenocarcinoma line Capan-1 in tissue culture and the nude mouse: morphologic, biologic, and biochemical characteristics. Am J Pathol 106:250-260, 1982
    • (1982) Am J Pathol , vol.106 , pp. 250-260
    • Kyriazis, A.P.1    Kyriazis, A.A.2    Scarpelli, D.G.3    Fogh, J.4    Rao, M.S.5    Lepera, R.6
  • 24
    • 0034634637 scopus 로고    scopus 로고
    • The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway
    • Yusta B, Boushey RP, Drucker DJ: The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway. J Biol Chem 275:35345-35352, 2000
    • (2000) J Biol Chem , vol.275 , pp. 35345-35352
    • Yusta, B.1    Boushey, R.P.2    Drucker, D.J.3
  • 25
    • 0037067677 scopus 로고    scopus 로고
    • GLP-2 receptor activation engages Bad and glycogen synthase kinase 3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase
    • Yusta B, Estall J, Drucker DJ: GLP-2 receptor activation engages Bad and glycogen synthase kinase 3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase. J Biol Chem 277:24896-24906, 2002
    • (2002) J Biol Chem , vol.277 , pp. 24896-24906
    • Yusta, B.1    Estall, J.2    Drucker, D.J.3
  • 26
    • 23844487799 scopus 로고    scopus 로고
    • The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells
    • Trumper J, Ross D, Jahr H, Brendel MD, Goke R, Horsch D: The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells. Diabetologia 48:1534-1540, 2005
    • (2005) Diabetologia , vol.48 , pp. 1534-1540
    • Trumper, J.1    Ross, D.2    Jahr, H.3    Brendel, M.D.4    Goke, R.5    Horsch, D.6
  • 27
    • 33644850386 scopus 로고    scopus 로고
    • Exendin-4 uses IRS2 signaling to mediate pancreatic beta-cell growth and function
    • Park S, Dong X, Fisher TL, Dunn SL, Omer AK, Weir G, White MF: Exendin-4 uses IRS2 signaling to mediate pancreatic beta-cell growth and function. J Biol Chem 281:1159-1168, 2006
    • (2006) J Biol Chem , vol.281 , pp. 1159-1168
    • Park, S.1    Dong, X.2    Fisher, T.L.3    Dunn, S.L.4    Omer, A.K.5    Weir, G.6    White, M.F.7
  • 28
    • 0027184119 scopus 로고
    • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells
    • Goke R, Fehmann H-C, Linn T, Schmidt H, Krause M, Eng J, Goke B: Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells. J Biol Chem 268:19650-19655, 1993
    • (1993) J Biol Chem , vol.268 , pp. 19650-19655
    • Goke, R.1    Fehmann, H.-C.2    Linn, T.3    Schmidt, H.4    Krause, M.5    Eng, J.6    Goke, B.7
  • 29
    • 0031789874 scopus 로고    scopus 로고
    • Exendin-(9-39) as an inverse agonist of the murine GLP-1 receptor: Implications for basal intracellular cAMP levels and β cell glucose competence
    • Serre V, Dolci W, Scrocchi LA, Drucker DJ, Efrat S, Thorens B: Exendin-(9-39) as an inverse agonist of the murine GLP-1 receptor: implications for basal intracellular cAMP levels and β cell glucose competence. Endocrinology 139:4448-4454, 1998
    • (1998) Endocrinology , vol.139 , pp. 4448-4454
    • Serre, V.1    Dolci, W.2    Scrocchi, L.A.3    Drucker, D.J.4    Efrat, S.5    Thorens, B.6
  • 30
    • 0346732301 scopus 로고    scopus 로고
    • Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways
    • MacDonald PE, Wang X, Xia F, El-kholy W, Targonsky ED, Tsushima RG, Wheeler MB: Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. J Biol Chem 278:52446-52453, 2003
    • (2003) J Biol Chem , vol.278 , pp. 52446-52453
    • MacDonald, P.E.1    Wang, X.2    Xia, F.3    El-kholy, W.4    Targonsky, E.D.5    Tsushima, R.G.6    Wheeler, M.B.7
  • 31
    • 9444231814 scopus 로고    scopus 로고
    • Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo
    • Baggio LL, Kim JG, Drucker DJ: Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo. Diabetes 53 (Suppl. 3):S205-S214, 2004
    • (2004) Diabetes , vol.53 , Issue.3 SUPPL.
    • Baggio, L.L.1    Kim, J.G.2    Drucker, D.J.3
  • 34
    • 0031874016 scopus 로고    scopus 로고
    • Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity
    • Naslund E, Backman L, Holst JJ, Theodorsson E, Hellstrom PM: Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity. Obes Surg 8:253-260, 1998
    • (1998) Obes Surg , vol.8 , pp. 253-260
    • Naslund, E.1    Backman, L.2    Holst, J.J.3    Theodorsson, E.4    Hellstrom, P.M.5
  • 36
    • 0036178688 scopus 로고    scopus 로고
    • Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: A strategy for production of pancreatic beta-cell lines for use in transplantation
    • Chepurny OG, Holz GG: Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation. Cell Tissue Res 307:191-201, 2002
    • (2002) Cell Tissue Res , vol.307 , pp. 191-201
    • Chepurny, O.G.1    Holz, G.G.2
  • 37
    • 0035553274 scopus 로고    scopus 로고
    • Pancreatic cancer: Factors regulating tumor development, maintenance and metastasis
    • Shi X, Friess H, Kleeff J, Ozawa F, Buchler MW: Pancreatic cancer: factors regulating tumor development, maintenance and metastasis. Pancreatology 1:517-524, 2001
    • (2001) Pancreatology , vol.1 , pp. 517-524
    • Shi, X.1    Friess, H.2    Kleeff, J.3    Ozawa, F.4    Buchler, M.W.5
  • 38
    • 0038650956 scopus 로고    scopus 로고
    • An introduction to pancreatic adenocarcinoma genetics, pathology and therapy
    • Kern SE, Hruban RH, Hidalgo M, Yeo CJ: An introduction to pancreatic adenocarcinoma genetics, pathology and therapy. Cancer Biol Ther 1:607-613, 2002
    • (2002) Cancer Biol Ther , vol.1 , pp. 607-613
    • Kern, S.E.1    Hruban, R.H.2    Hidalgo, M.3    Yeo, C.J.4
  • 39
    • 0037902984 scopus 로고    scopus 로고
    • Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
    • Vilsboll T, Krarup T, Sonne J, Madsbad S, Volund A, Juul AG, Holst JJ: Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab 88:2706-2713, 2003
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2706-2713
    • Vilsboll, T.1    Krarup, T.2    Sonne, J.3    Madsbad, S.4    Volund, A.5    Juul, A.G.6    Holst, J.J.7
  • 40
    • 16244388984 scopus 로고    scopus 로고
    • A randomized, open-label, crossover study examining the effect of injection site on bioavailability of exenatide (synthetic exendin-4)
    • Calara F, Taylor K, Han J, Zabala E, Carr EM, Wintle M, Fineman M: A randomized, open-label, crossover study examining the effect of injection site on bioavailability of exenatide (synthetic exendin-4). Clin Ther 27:210-215, 2005
    • (2005) Clin Ther , vol.27 , pp. 210-215
    • Calara, F.1    Taylor, K.2    Han, J.3    Zabala, E.4    Carr, E.M.5    Wintle, M.6    Fineman, M.7
  • 41
    • 17644401388 scopus 로고    scopus 로고
    • Pharmacokinetics of an oral drug (acetaminophen) administered at various times in relation to subcutaneous injection of exenatide (exendin-4) in healthy subjects
    • Blase E, Taylor K, Gao HY, Wintle M, Fineman M: Pharmacokinetics of an oral drug (acetaminophen) administered at various times in relation to subcutaneous injection of exenatide (exendin-4) in healthy subjects. J Clin Pharmacol 45:570-577, 2005
    • (2005) J Clin Pharmacol , vol.45 , pp. 570-577
    • Blase, E.1    Taylor, K.2    Gao, H.Y.3    Wintle, M.4    Fineman, M.5
  • 42
    • 23944488440 scopus 로고    scopus 로고
    • Dose-response for glycaemic and metabolic changes 28 days after single injection of long-acting release exenatide in diabetic fatty Zucker rats
    • Gedulin BR, Smith P, Prickett KS, Tryon M, Barnhill S, Reynolds J, Nielsen LL, Parkes DG, Young AA: Dose-response for glycaemic and metabolic changes 28 days after single injection of long-acting release exenatide in diabetic fatty Zucker rats. Diabetologia 48:1380-1385, 2005
    • (2005) Diabetologia , vol.48 , pp. 1380-1385
    • Gedulin, B.R.1    Smith, P.2    Prickett, K.S.3    Tryon, M.4    Barnhill, S.5    Reynolds, J.6    Nielsen, L.L.7    Parkes, D.G.8    Young, A.A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.